Tolerance - Amount of grapefruit juice and its affects

[blueflame128]

So little Johny Doe down the road asked me an interesting question the other day...

He knows that drinking grapefruit juice 1/2 hour before taking your opiate will potentiate the effects. He said he usually just drinks a glass, but he was wondering what would happen if he drank nothing but 100% pure grapefruit juice all day, and then took his normal dose. Does the amount of juice drank affect how much it will potentiate your hydro or whatever?

[MEKONE]

As SWIM said in another post he drinks GFJ all day like if it was water.In fact water and GFJ is all SWIM drinks all day as he really likes the taste of it.SWIM can say for sure there is a diffrence in how much GFJ is drank and he can say that his effects last a bit long and a bit harder than if he were to drink just water.

Awhile ago SWIM drank his meds W/O GFJ and can honestly say that he DID feel mild W/D's,so there is a connection to this and it may be due tothe amount of GFJ SWIM consumes daily.

[Creeping Death]

SWIM once ate a whole grapefruit after his buprenorphine buzz started to fade away. It was delicious, and it made SWIM start nodding again as he did in the peak of the buzz. And the more swim ate, the more he felt.

So yes, for SWIM it has worked very well. Maybe it works even better if you eat it than if you drink it.

[Matt The Funk]

SWIM use to drink GFJ all day to help potentate all his DOC's and he thinks it worked really well. SWIM realized how much more $$ efficient it was, and didn't stop till it became too much to keep buying GFJ all the time (annoying). SWIM thinks after a certain amount being drunk it probably won't make much of a difference, but a few glasses will help potentiate, anything after that SWIM thinks just keeps that high potentation going, but to be honest he isn't sure of the exact pharmalogical effects.

EDIT: SWIM isn't sure about how long the GFJ lasts....he understands how it works.

[drgreenthumb881]

Swim uses either one glass of 100% grapefruit juice, or eats one whole fresh grapefruit, and always waits 1 full hour. The fresh fruit is better in swims opinion, especially since in the north bronx really good ruby red grapefruits are 4 for a dollar. As far as swim knows, the grapefruit inhibits an enzyme in the liver (cy-pd 24) or something like that lol, the name might not be exactly correct, but thats def. what happens, and it slows down the metabolization of said d.o.c.'s, but it also does the same for acetaminophen/paracetamol, so be careful, i hear excess of those two can cause liver damage after many years, swim rarely consumes alcohol therefore doesn't worry about it. Hope this helps. peace, swiDrGreen

[Spucky]

People have to be very carefull,
some People already lost their lives,
special in the combination with Methadone and other strong Opioids.
The serum-level will increase uncontrollable.
Ever Pack of Juice is different from the other!

Grapefruit Juice Squeezes More Life
Out Of Methadone?

ANN ARBOR, MI - PSLGroup, November
19, 1997 — Researchers, led by a team
from the University of Michigan Medical
Center, have isolated a pair of substances in
grapefruit juice that cause greater
absorption of certain drugs in the human
body. The new findings are published in the
November 1997 issue of the journal Drug
Metabolism and Disposition.
The key to how grapefruit juice enhances
drug absorption lies in the interaction
between the grapefruit juice and an enzyme
found in the small intestine. Paul Watkins,
M.D., director of the U-M General Clinical
Research Center, and his colleagues have
isolated two substances in grapefruit, called
furanocoumarins, that are responsible for
the so-called grapefruit effect. Watkins said
the two components act like suicide
bombers, attaching themselves to the
enzyme and destroying its ability to
interfere with drug absorption.
16
The enzyme, known as CYP3A4, normally
acts as a sort of gatekeeper against certain
types of medication, including those
prescribed for high blood pressure, heart
disease, allergies, AIDS, organ
transplantation, [and possibly, methadone].
These types of drugs, unlike most
medications, are not absorbed efficiently in
the intestines because they are largely
broken down by CYP3A4 in the intestinal
wall. Watkins said people typically have
varying levels of the enzyme in their
intestines — which appears to explain why
some individuals absorb greater amounts of
a given medication than others.
Another interesting finding in the study was
that the concentration of the active
ingredients varies dramatically among
grapefruits and grapefruit juices, even
within the same product line. This is most
likely because of growing conditions in
different regions and because
manufacturers typically buy their
grapefruits from many areas.

Reputation Comments on this post:

factual info from an outside source specific to the topic :)