Drug info - Adderall tolerance different from ritalin?

[radplane]

Hey, I just had a quick question. swim has been dosing on adderall for the past week and is starting to detect some tolerance, would the tolerance to amphetamines affect Methylphenidate (specifically ritalin) tolerance at all? I wouldn't't think they would have any similaritiy but im just making sure, thanks!

[lostinla]

This is quick and I had a note on this but lost has lost it. Ritalin can make swiy tolerant and also have a bit of withdrawl from it, not sure if coming off is the issue, the amphetamines sometimes have a more stimulating (obviously) euphoric affect that can definitely make tolerance acquire in ones system very easily and quick. As far as ADHD it's the individual. The 'crash' swiy can feel after even just one adderal is somewhat quite dramatic for many, sometimes even crying, feeling bad for an hour or so. After any length of use use caution with the adderal and taper off. As for the Ritalin, tapers are also used as some have a harder time with the tolerance/withdrawls as in experiences swim thinks it is due to the fact that swiys can sometimes take a bigger dose of ritalin and do this for longer periods of time, thinking safer than adderal. Boy, it's late. Sorry, I truly hope this wasn't confusing... Yes class different, depends on the tried and truth in the individual

[Cryptic Concoction]

Both methylphenidate and the amphetamine salts constituting adderall appear to mediate their effects through monamine (monoamines being dopamine, norepinephrine, serotonin, and epinephrine) agonism (chiefly dopamine and norepinephrine, and to a lesser extent, serotonin).

While I have yet to encounter any literature elucidating the precise mechanism through which methylphendiate exerts its effects, it appears to share neurochemical effects somewhat reminiscent of amphetamine, increasing extracellular levels of dopamine, norepinephrine, and serotonin. It is currently postulated that amphetamine (and for this instance, I will extend the application of this hypothesis to the amphetamine salts comprising adderall) may render its effects via reversing the action of dopamine, norepinephrine, and serotonin reuptake inhibitors, resulting in the exodus of these monoamines into the synapse.

In a simplified sense, tolerance is the direct result of compensatory mechanisms employed by the body in order to restore the state of equilibrium that is upset by drug use. In the case of methylphenidate and amphetamine, both of which appear to facilitate the transmission of dopamine, norepinephrine, and serotonin, I would conjecture that tolerance would principally be a result of adaption of the monoaminergic systems.

Most likely, this tolerance would be mediated via either decreased synthesis of the monoamines adderall and methylphenidate appear to facilitate the release of, or desensitization of hyperstimulated monoaminergic receptors. Because the effects of both methylphenidate and adderall appear to be contingent upon the availability of monoamines (principally dopamine and norepinephrine), either of these physiological alterations would result in attenuated effects of both of these drugs.

Thus, if we assume that the tolerance SWIY experiences from amphetamine can be primarily attributed to measures implemented by his central nervous system to reduce monoaminergic activity (because adderall increases monaminergic activity), we may infer that he will also experience tolerance to methylphenidate (because both drugs appear to rely upon the availability of similar neurotransmitters as well as the sensitivity of similar receptors).

In short, given the ostensible similarities in their neurochemical effects (both appear to be monoamine agonists), I would speculate that some cross-tolerance would be observed.

Reputation Comments on this post:

Well written, in depth explination