Opinions - Methylone VS Mephedrone

[shatteredparadigm]

Hey, tried to research this myself but my searches on the forums were mostly unsuccessful. What are the primary differences between these two chemical? From what I read they seem somewhat similar. What are the pros and cons? Any opinions?

[geezaman]

Can any other members improve or expand this thread a little, even if only with posts written elsewhere copied here. Snuffkin would himself, but hasnt yet tried methylone so cannot.
Reading the methylone experiences thread it seems many get away without nausea and hangover or don't report it. Here on the other hand two users point to negative effects.

Doing a title search for Methylone and Mephedrone only provides 3 threads, this one of them so Snuffkin assumes many interested in combining the two or comparisons of them might come by, a few direct short comparisons between the two rather than situation specific trip reports would be interesting too.
Peace
Geezaman

[Routemaster Flash]

SWIM's two or three experiences with methylone suggests it's more or less a watered-down version of MDMA. Pleasant, certainly, and good value for money, but not worth it if you can get hold of good ecstasy crystal or pills.

From his experiences of mephedrone - most successfully last night, as it happens - this drug is everything that cocaine promises to be, but isn't. Euphoric, energetic, social and chatty, lasts longer than coke (but not *too* long), no comedown or hangover to speak of. Only downside is, some n00bs find it painful to snort (not SWIM though, he's taken yopo - YOWCH!) but SWIM guesses that's just because it's a pure drug compound and not mostly powdered milk or Nutrasweet like most 'cocaine' is. It's certainly not as bad as snorting crushed-up pills, anyway.

In summary: mephedrone > methylone.

[geezaman]

Originally Posted by Routemaster Flash

.... Only downside is, some n00bs find it painful to snort (not SWIM though, he's taken yopo - YOWCH!) but SWIM guesses that's just because it's a pure drug compound and not mostly powdered milk or Nutrasweet like most 'cocaine' is. It's certainly not as bad as snorting crushed-up pills, anyway....

Snuffkin found the snorting a quite painful, though hasn't been doing so for some time so believes he's returned to a noob status at it. Of course in comparison to coke, these two compounds do not have that quick onset numbing pain relief that coke of any quality does. However he has in the past done yopo 1:1 with bicarb of soda so knows fully where SWIY is coming from with the analogy.

Thankyou for posting a more qualitative comparison.

Peace
Geezaman

[Routemaster Flash]

Originally Posted by geezaman

Snuffkin found the snorting a quite painful, though hasn't been doing so for some time so believes he's returned to a noob status at it. Of course in comparison to coke, these two compounds do not have that quick onset numbing pain relief that coke of any quality does. However he has in the past done yopo 1:1 with bicarb of soda so knows fully where SWIY is coming from with the analogy.

Thankyou for posting a more qualitative comparison.

Peace
Geezaman

Cheers.

Interestingly enough, SWIM started to notice a bit of teeth/gums numbing after his second or third line of mephedrone, though nothing as strong as with coke. It's fascinating how compounds that are radically different chemically can have sometimes have very similar pharmacological effects.

[nibble]

Originally Posted by Routemaster Flash

Cheers.

Interestingly enough, SWIM started to notice a bit of teeth/gums numbing after his second or third line of mephedrone, though nothing as strong as with coke. It's fascinating how compounds that are radically different chemically can have sometimes have very similar pharmacological effects.

Well to my knowledge mephedrone does not posses any local anaesthetic effects like those of cocaine, so any numbing felt was probably due to it's central action.

[Routemaster Flash]

Originally Posted by nibble

Well to my knowledge mephedrone does not posses any local anaesthetic effects like those of cocaine, so any numbing felt was probably due to it's central action.

That seems unlikely, because in that case why would numbing be felt at the exact spot the drug was administered? And with respect, you could be the world's foremost authority on 4-methylmethcathinone and still know very little about it...I mean, people have been using this stuff to get high for all of what, a year? The effect was unlikely to have been placebo, since SWIM wasn't expecting it as he knew beforehand it was in the amphetamine family and not chemically related to cocaine.

Isn't at least plausible that if this substance has a cocaine-like effect on the CNS (and it certainly seems to), then it may have a somewhat similar effect on the nerves of the peripheral nervous system?

[nibble]

Originally Posted by Routemaster Flash

That seems unlikely, because in that case why would numbing be felt at the exact spot the drug was administered? And with respect, you could be the world's foremost authority on 4-methylmethcathinone and still know very little about it...I mean, people have been using this stuff to get high for all of what, a year? The effect was unlikely to have been placebo, since SWIM wasn't expecting it as he knew beforehand it was in the amphetamine family and not chemically related to cocaine.

Isn't at least plausible that if this substance has a cocaine-like effect on the CNS (and it certainly seems to), then it may have a somewhat similar effect on the nerves of the peripheral nervous system?

Sure, I don't know with any certainty but SWIY is the only person I have ever come across who describes this as having a numbing effect. Usually it is quite the opposite with an often intense burning sensation being felt.
The structure of 4-methylmethcathinone is also not substantially similar to any known local anaesthetic, and compounds that are very similar do not possess any local anaesthetic effects.
It's certainly not an imposibility but I just feel that it is pretty unlikely, even based purely on anecdotal evidence there's not really anything to suggest it does. Surely the effect would have been much more pronounced in SWIY's nasal cavity than SWIY's gums?

[Lehendakari]

Back on topic, I prefer methylone over mephedrone any time. Both chemicals are dirty in swim's opinion, he prefers the "cleanless" of pure uppers or SDRI's and for swim neither feels remotely similar to good coke, but mephedrone feels more dirty, with worse side-effect profile and comedown.

Euphoria however is more intense with mephedrone but also lasts a lot less and its like more "artificial." Mephe smell is also an issue methylone doesn't have.

[vantranist]

To swim the high of methylone was simply nice, but honestly not worth ever taking unless it was free.


Mephedrone is better... it can make SWIM feel pretty damn good. Still, it can't compare with the classics.

[Routemaster Flash]

Originally Posted by Lehendakari

Back on topic, I prefer methylone over mephedrone any time. Both chemicals are dirty in swim's opinion, he prefers the "cleanless" of pure uppers or SDRI's and for swim neither feels remotely similar to good coke, but mephedrone feels more dirty, with worse side-effect profile and comedown.

Euphoria however is more intense with mephedrone but also lasts a lot less and its like more "artificial." Mephe smell is also an issue methylone doesn't have.

This just goes to show the truth of that old chestnut about 'different strokes...', I suppose. SWIM doesn't think meph feels 'dirty' at all, though maybe we're using somewhat different meanings of the word...also he never had any kind of comedown from it, though he guesses he's just lucky like that (SWIM's body waits until he's had a heavy night on the booze before it really punishes him, yeesh!) and the main side effect was a bit of a 'gurn', though not as bad as MDMA. As for smell, SWIM never noticed any to speak of - perhaps a impure synthesis in your batch? Again, could just be a personal sensitivity to different compounds.

And I assume 'SDRI' = 'selective dopamine reuptake inhibitor'? SWIM's heard of the mechanism but not that particular abbreviation.

[nibble]

Originally Posted by Routemaster Flash

This just goes to show the truth of that old chestnut about 'different strokes...', I suppose. SWIM doesn't think meph feels 'dirty' at all, though maybe we're using somewhat different meanings of the word...also he never had any kind of comedown from it, though he guesses he's just lucky like that (SWIM's body waits until he's had a heavy night on the booze before it really punishes him, yeesh!) and the main side effect was a bit of a 'gurn', though not as bad as MDMA. As for smell, SWIM never noticed any to speak of - perhaps a impure synthesis in your batch? Again, could just be a personal sensitivity to different compounds.

And I assume 'SDRI' = 'selective dopamine reuptake inhibitor'? SWIM's heard of the mechanism but not that particular abbreviation.

SDRI generally refers to a Serotonin-Dopamine Reuptake Inhibitor if I recall correctly. SWIM would agree that this doesn't feel particularly "dirty" not any more than other common stimulants anyway, and less so than say amphetamine. If a swimmer takes it easy and does not do large amounts, keeps hydrated and makes sure to leave plenty of time (several weeks) between their use of stimulants the comedown is not particularly bad at all, much less than strong serotonergic drugs like MDMA. The word "dirty" in this context is indeed very subjective though.

[BumpBump]

swim agrees methylone is quite light weight but the come down is not!
Mephedrone has a bad comedown also... spaced out for a few days, and very depressed.

swim does not take either any more

[Tango]

SWIM had many exp. with Mephedrone and only 2 with Methylone. The first Methylone exp was great but the comedown was not worth it. The second time around SWIM did not bomb but insuflated it, which the effects where not like the first time which was bombed. The comedown was not as bad this way but nor was the effect as strong. Insuflating Methylone made SWIM's nose numb.SWIM has insuflated the last few times with Mephedrone. The effects become weaker as the urge for greater cosumption grew. The initial comedown of Mephedrone was not to bad but the next few days made SWIM had a very strong urge for more and was kinda depressed but SWIM does take an SSRI (Effexor) which makes the depression not as bad. SWIM does not take the SSRI the morning of the day SWIM decides to take Mephedrone and only takes it when he is done which helps him sleep for some reason.

[nibble]

Originally Posted by Tango

SWIM had many exp. with Mephedrone and only 2 with Methylone. The first Methylone exp was great but the comedown was not worth it. The second time around SWIM did not bomb but insuflated it, which the effects where not like the first time which was bombed. The comedown was not as bad this way but nor was the effect as strong. Insuflating Methylone made SWIM's nose numb.SWIM has insuflated the last few times with Mephedrone. The effects become weaker as the urge for greater cosumption grew. The initial comedown of Mephedrone was not to bad but the next few days made SWIM had a very strong urge for more and was kinda depressed but SWIM does take an SSRI (Effexor) which makes the depression not as bad. SWIM does not take the SSRI the morning of the day SWIM decides to take Mephedrone and only takes it when he is done which helps him sleep for some reason.

An SSRI could definately affect the methylone in particular even if swiy didn't take the SSRI on the day of experimentation, the drug itself and its metabolites would be present in blood for several days after cessation.
Mephedrone appears to be acting more on dopamine so perhaps it was less affected by the use of an SSRI than was the methylone.

To compare the two compounds SWIM would see methylone as an MDMA-lite and mephedrone would be more like a sort of hybrid between cocaine and amphetamine. If a swimmer doesn't particularly enjoy the almost purely hedonistic effects of drugs like cocaine then they probably won't be a big fan of mephedrone. Methylone on the other hand has more of the empathogenic effects of MDMA and similar drugs.

[Tango]

So how long would a one need to be off an SSRI before it is fully out of ones system?

[nibble]

Originally Posted by Tango

So how long would a one need to be off an SSRI before it is fully out of ones system?

Difficult to say, the half-lives of venlafaxine and its active metabolite aren't that long but that can be deceptive. I'd say 2-3 days for anything active to be eliminated. But using an SSRI regularly will have effects on your serotonergic system for quite some time after you stop taking it anyway, it could take months to return to complete normality.

[lineartransform]

Originally Posted by Routemaster Flash

SWIM's girlfriend uses this method and swears by it; SWIM plans on trying it next time he obtains some. But only or two people SWIM knows - wimmin who can't take their drugs, basically - have made a fuss about the snorting, SWIM doesn't mind it.

Yes, but SWIY should be aware that many prefer oral/rectal ingestion over insufflation not because of the pain (which is over quickly and really not that bad) but instead because the quality of effects are so much better.

Insufflation makes SWIM feel clenchy, wired, and sweaty, whereas rectal/oral administration drastically reduces gurning and creates a more euphoric, relaxed high. Comedown/day after effects are reduced, and you don't get that "flu" feeling in your nasal passages.

Rectal has a comparable efficiency mg/mg as snorting (ie you don't need drastically more), and is far less "moreish" as well.

[nibble]

Originally Posted by lineartransform

Yes, but SWIY should be aware that many prefer oral/rectal ingestion over insufflation not because of the pain (which is over quickly and really not that bad) but instead because the quality of effects are so much better.

Insufflation makes SWIM feel clenchy, wired, and sweaty, whereas rectal/oral administration drastically reduces gurning and creates a more euphoric, relaxed high. Comedown/day after effects are reduced, and you don't get that "flu" feeling in your nasal passages.

Rectal has a comparable efficiency mg/mg as snorting (ie you don't need drastically more), and is far less "moreish" as well.

Yep, agree with this completely. Many like to take a moderate oral dose and top up with a few small lines to help extend the effects. But of course the more you take the worse the comedown and lingering negative feelings will be.

[Joel2k11]

Hard to decide for SWIM. To him methylone is alot more speedy and manic. He finds mephedrone more fluffy and chilled. So methylone for a night out, mephedrone for a night in.

[Cuberun]

The answers are easily found in the meph n methylone threads... but to summarize

Which drug does SWIY find gives the best euphoria and general high?
M1 has ... or used(lost its magic) to have a better euphoria than Mephedrone (hits serotonin more)

Which one is the best value for money?
Comes down to taste really.. m1 euphoria lasta bit longer, mephedrone is a little bit cheaper. not much of a gap.

Which substance has the least amount of negative effects?

methylone.. although don't be surprised if you geta cold sore after taking m1.
meph seems to cause way more bodyload + tachyardia.

Which one will be more likely to blow my socks off?
again, tastes... some people fly higher on m1, others on mephedrone.

whilst SWIM is here he would also like to know the recommend dosage for a oral dose of methylone, thanks.
180-250mg (220mg), 250mg-300mg for tolerant people.

[JackandBlood]

SWIM recently tried Mephedrone. No prior experience with either MDMA or Methylone. SWIM was very happy with the results. SWIM feels Mephedrone has a stimulant property that is the exact opposite of Caffeine, which SWIM does not tolerate well. The stimulant property SWIM felt was a euphoric, calm, and brillant type of energy with no nausea, jitteriness, or anxiety typical of Caffeine for SWIM. SWIM would describe the feeling as something a Xen Buddist monk may feel after hours of meditation.

In addition SWIM's first experience with the substance yielded the most intense and productive workout/martial arts sessions he/she has ever experienced. SWIM performed weapons (real Samurai swords with razor edge, and real Ironwood Eskrima fighting sticks) manuevers with a grace and power he/she has never been able to do before. SWIM is throughly impressed with the substance.

JnB

[JackandBlood]

SWIM finds mephedrone increases focus and energy. You know that twirling double katana maneuver performed by Ryan Reynold's character in the latest X-men movie? SWIM totally nailed it and thats with real steel katanas with their difficult point of balance rather than those hollywood fake dull aluminum ones that are perfectly balanced at the handle.

More to the point SWIY will be in complete control while on mephedrone. No intoxication causing bad judgement calls or dangerous decisions. SWIM performed the manuver once then quit while he/she was ahead (and with all limbs intact)

To contribute to the actual point of the thread (rather than SWIM just bragging ). SWIM has found undesirable effects of super high pulse rate (normal blood pressure but bpm pushing 100+) and the substance to be very fiendish. Methylone does not so severely push bpm from what SWIM has read.

Cheers

JnB

[claireyface]

Originally Posted by nibble

Sure, I don't know with any certainty but SWIY is the only person I have ever come across who describes this as having a numbing effect. Usually it is quite the opposite with an often intense burning sensation being felt.
The structure of 4-methylmethcathinone is also not substantially similar to any known local anaesthetic, and compounds that are very similar do not possess any local anaesthetic effects.
It's certainly not an imposibility but I just feel that it is pretty unlikely, even based purely on anecdotal evidence there's not really anything to suggest it does. Surely the effect would have been much more pronounced in SWIY's nasal cavity than SWIY's gums?

My unicorn certainly felt numbing from meph when she first started taking it. As well as doing as lines she would just dab little bits onto her tongue with her finger, and that spot would always go a bit numb.

She hasn't administered it in such a way for a while now, but she definitely felt it because it was one of the things that encouraged her to persevere with a drug she did not initially enjoy. She has never felt any burning from it at all. My unicorn thought everybody felt the little bit of tingly numbing from it... how curious....

[nibble]

Originally Posted by claireyface

My unicorn certainly felt numbing from meph when she first started taking it. As well as doing as lines she would just dab little bits onto her tongue with her finger, and that spot would always go a bit numb.

She hasn't administered it in such a way for a while now, but she definitely felt it because it was one of the things that encouraged her to persevere with a drug she did not initially enjoy. She has never felt any burning from it at all. My unicorn thought everybody felt the little bit of tingly numbing from it... how curious....

That is unusual though, there's nothing to suggest that this would inhibit sodium ion channels.