Combinations - sometimes it sucks being a drug user (drug interactions on codeine)

[mashed]

sometimes being a drug user sucks.
yesterday swim got ripped off £10 trying to buy viocodon,ripped off £10 buying cannabis (the green was so wet it was soaking through the skin!)and ripped of £20 buying valium.

never mind swim thought fall back on old relibles,the chemist so swim went and spent the last off his money (being un employed sucks too) on a few packs of co codamol and grapefruit juice.

so swim done a cwe off 400 mg codeine,which is enough to finish me off now swim havnt got a tollerance.swim waited and waited and had a really weird experiance.swim had all the opid effects nausea,itchies,slowed breathing.just absolutley NO euphria at all.


swim is having a nightmare situation,swim cant get NO effects from any opiuds.swim drank poppy tea this morning 50 grams off the stuff and the same thing happened as with the codeine.

so swim wants to know whats causing this.
swim narrowed it down to a few things

1.could it be cause by tollernace from taking lopermide 10mg every day for about a week when coming off h?

2.could the grapefruit juice have stopped it working?

3.swim is prescribed large amounts off mitrazepine too help swim sleep.the last dose was 6 days ago.could there still be enough in swims sistem to stop oipids working? swim had similar effects when swim mixed anti depressants and opids before- all the side effects but no euphria

any help would be greatly appreciated
thanks

[RoboCodeine7610]

Don't know about the poppy tea, but the lack of effects from the codeine could have been caused by a CYP2D6 deficiency.Here's some info on it:

http://en.wikipedia.org/wiki/Codeine#Pharmacokinetics

[mashed]

thanks for the reply,the weird thing is though codeine used to work great for me

[RoboCodeine7610]

thanks for the reply,the weird thing is though codeine used to work great for me

Well maybe you have a higher tolerance than you think you do.But let me tell you that codeine does weird things for swim too.Like one day he'll get extremely high and euphoric, and the next day get nothing but a mild buzz.

Also, make sure that your CWE technique is as good as it was back when codeine affected you more.I recommend that you to use "Robo's refined CWE", here it is:

ROBO'S REFINED CWE
You'll need:
-water(preferably bottled)
-a baker or other container capable of measuring ml.
-a funnel
-tissue paper or as SWIJulian suggested woman's stocking
-coffee filters or preferably lab filters

Okay so here's the procedure:

1-Heat the water to about 30C, just above room temp.Pur the desired amount of water in the baker or glass (swim uses 100ml for 20 tablets, also works well for up to 30 tablets)

2-Crush the tablets until they're a fine powder (the finer the better) and add them to the water, stir until you can see no more chunks.

3-While you wait for the tablets to dissolve wet the paper tissue or the cloth you were talking about and place it on the funnel.Wet it first so it doesn't absorb your codeine.

4-All the tablets should be dissolved by now, check for chunks in the bottom of the glass.
Place the funnel on top of a tall glass and filter the mix through it.
After it's done pur a tiny little bit of water in the baker with the residue ad pur it on the filter, this will ensure that you get all the codeine out.

5-Discard the tissue paper and wash the funnel and the baker.Now pur the filtered solution into the baker and look at how many ml of water are left.
This will give you an aproximate idea on your yield.

6-Put the baker in the freezer, and wait until you see a little bit of ice on top.

7-While you wait for the solution to cool, place the lab or coffee filters in the funnel making sure they're wet before filtering.

8-Filter the solution through the coffee/lab filter.If it takes too long you might wanna filter inside the fridge so that it stays cool.

9-The filtered solution should be as clear as water,Drink and enjoy.You might wanna wait until you have an empty stomach as this greatly potentiates the codeine.