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  #1  
Old 22-01-2009, 08:23
dimichaeltryptamine dimichaeltryptamine is offline
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Does Nicotine affect the effect of other drugs?

Swim uses Nicotine daily, but as soon as THC enters his system Nicotine becomes much more noticeable when consumed. So does Nicotine affect the mind differently when you're under the influence of other substances?
  #2  
Old 22-01-2009, 10:38
poppypreacher poppypreacher is offline
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AW: Does Nicotine affect the effect of other drugs?

Swim experienced that tobacco kicks much more when he is on opiates and loves smoking when on it, but when stoned, he doesn't like the effect of tobacco much and while tripping on magic mushrooms he didn't noticed any effect of nicotine. So obviously some drugs affect the brain chemistry in a way, that nicotine doesn't work similar to the sober brain.

Here's an article, which may be interesting, though its about the effect of tobacco to cannabis and not reverse


Adulteration of cannabis with tobacco, calamus, and other cholinergic compounds
John M. McPartland
Cannabinoids 2008;3(4):16-20

http://www.drugs-forum.com/forum/loc...tid=98&id=6440

Post Quality Evaluations:
thanks for the awesome article

Last edited by poppypreacher; 22-01-2009 at 14:49.
  #3  
Old 22-01-2009, 17:25
dimichaeltryptamine dimichaeltryptamine is offline
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Re: Does Nicotine affect the effect of other drugs?

Swim thanks Swiy. Very helpful. Swim started out a while back smoking a cigarette after each time he would use cannabis only because he was twelve and didn't want the school to know of his habits, then one day he just noticed the effect. I'm sure it's stronger or lighter effect depending on who uses it.
  #4  
Old 22-01-2009, 22:58
Systemdoll Systemdoll is offline
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Re: Does Nicotine affect the effect of other drugs?

For swim's experience, Nicotine (medical or Snus) potentialise a lot the effects of Oxycodone.

Cool.
  #5  
Old 23-01-2009, 10:50
Jatelka Jatelka is offline
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Re: Does Nicotine affect the effect of other drugs?

Most Definitely! There's a great paper here

that looks at the effect of nicotine on various pharmaceuticals, including Tricyclics, SSR's, Benzodiazepines and Typical/Atypical antipsychotics

Last edited by Jatelka; 09-07-2009 at 06:08.
  #6  
Old 23-01-2009, 13:51
chillinwill chillinwill is offline
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Re: Does Nicotine affect the effect of other drugs?

Red Rock loved to smoke when on DXM, opiates, and of course while drinking. He found that nicotine potentates the effect of DXM and smoking is very, very enjoyable while drinking alcohol. On opiates, he doesn't have a care in the world and could chain smoke then as well
  #7  
Old 23-01-2009, 14:00
doublezero doublezero is offline
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Re: Does Nicotine affect the effect of other drugs?

swim says yes, but u wouldnt notice it,,,unless u wernt an addictive smoker,
  #8  
Old 23-01-2009, 18:07
Systemdoll Systemdoll is offline
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Re: Does Nicotine affect the effect of other drugs?

Thank you Jatelka for your link. Do you have any infos on effects and potentialisation of opioid and nicotine ?
  #9  
Old 12-02-2009, 20:04
Systemdoll Systemdoll is offline
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Re: Does Nicotine affect the effect of other drugs?

A friend of mine write a little text about interaction between oxycodone and nicotine:



An illustration of the metabolic pathways of oxycodone with the associated
CYP-enzymes after oxidative (white arrows) and reductive (black arrows) reactions.
The percent values are given for normal conditions (without nicotine).

The values represent percentages of plasma consentrations (Cmax values, ng/ml) after a
single 15 mg oral dose of oxycodone in humans. Modified from Lalovic et al. (2006).
Oxycodone has relatively high oral bioavailability in humans (60-87%) (Leow et al.
1992; Pöyhia et al. 1992b) compared with that of morphine (19-30%).
Oxycodone is extensively metabolized in the liver and only 8 to 14 % is excreted
in unchanged or conjugated forms to urine (Pöyhia et al. 1992b). According to Lalovic
et al., oxycodone undergoes minimal oxidation in the intestinal mucosa during the firstpass
oxidative metabolism compared with the liver (Lalovic et al. 2004).

In humans, the main oxidative metabolic route of oxycodone is N-demethylation
at the 17-position by CYP 3A4/5 (CYP) 3A4/5 to noroxycodone (Pöyhia et al. 1991;
Pöyhia et al. 1992b; Kaiko et al. 1996; Heiskanen et al. 1998; Lalovic et al. 2004;
Lalovic et al. 2006).
Noroxycodone is further metabolised to the reduced forms α- and
β-noroxycodol (Fig. 1). A reductive metabolism of oxycodone occurs with a lower rate
to α- and β-oxycodol (Fig. 1).

Oxymorphone is a 3-O-demethylation metabolite of
oxycodone and it is formed after oxidative reaction mainly catalysed by CYP 2D6 in
humans (Otton et al. 1993). Oxymorphone is extensively conjugated and excreted in
urine mainly as in the conjugated form (Cone et al. 1983; Pöyhia et al. 1992b; Kirvelä et
al. 1996; Lalovic et al. 2006). The reductive metabolites of oxymorphone are α- and β-
oxymorphol (Fig1).
Noroxymorphone is formed mainly after O-demethylation of
noroxycodone by CYP 2D6. Also, a minor route is by N-demethylation of
oxymorphone to noroxymorphone via CYP 3A4 and 2D6 approximately with a 20- to
30-fold lower rate compared with noroxycodone O-demethylation (Lalovic et al. 2004).

Post Quality Evaluations:
Great info and presented extremely clearly
Nice diagram
  #10  
Old 23-03-2009, 20:08
Enzo_Guy Enzo_Guy is offline
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Re: Does Nicotine affect the effect of other drugs?

SWIM has found both alcohol and cannabis boost the effects of smoking a cigarette. Cannabis also gives his favorite cigars a better flavor.
  #11  
Old 05-06-2009, 03:40
lulz Gold member lulz is offline
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Re: Does Nicotine affect the effect of other drugs?

Smoking a cigarette generally dulls a drug experience for swim. If stoned, a cigarette makes him feel less stoned. If drunk, less drunk. It dampens euphoria as well. Swim thinks his brain behaves uncommonly in this respect though.
  #12  
Old 08-07-2009, 21:31
ziek ziek is offline
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Re: Does Nicotine affect the effect of other drugs?

Drinking and Smoking is lovely. Both seem to taste so nice and a beer and a cigarette feel like the perfect match!
  #13  
Old 16-07-2009, 01:10
nibble nibble is offline
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Re: Does Nicotine affect the effect of other drugs?

Nicotine increases the subjective euphoria of many drugs through it's well-known property of increasing dopamine tranmission in the reward pathway. Well known examples would be cocaine users often chain smoking when using as it augments and intensifies the high, the same goes for just about any drug that increases dopamine in the reward pathway to an appreciable extent.

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drugs, dxm, magic mushrooms, mushrooms, nicotine, nicotine effects, oxycodone, oxymorphone, percocet, thc, tobacco

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