Health - Piracetam and kidney damage

[dexbud]

Hi SWIMers,

SWIM has questions regarding the toxicity (or non-toxicity) of peracetam and supposedly the other -cetams... SWIM took Piracetam for a while, noticing massive effects from very lose doses (SWIM is inherently sensitive)... it was always distressful on SWIMs kidneys though... eventrually, SWIM took a 800mg pill and had a near-hospitalizing renal event of some kind... urine output slowed for weeks (once a day only) and urine became foamy (nad remains this way, 2.5 years later)...

what is SWIYs experience with negative health consequences of piracetam and related compounds?

PS- SWIM realizes SWIM notation is perhaps not necessary here, she simply wants to stay in the habit.

-DB

[Rocketjones]

All ways research a drug before experimenting.
"Due to the effect of piracetam on platelet aggregation, caution is recommended in patients with underlying disorders of hemostasis, major surgery or severe hemorrhage.
Abrupt discontinuation of treatment should be avoided as this may induce myoclonic or generalised seizures in some myoclonic patients.
As piracetam is almost exclusively excreted by the kidneys caution should be exercised in treating patients with known renal impairment. In renally impaired and elderly patients, an increase in terminal half-life is directly related to renal function as measured by creatinine clearance. Dosage adjustment is therefore required in those with mild to moderate renal impairment and elderly patients with diminished renal function.
/\
Taken from wikipedia.

[snapper]

There is no data out there which implicates piracetam with causing kidney damage, though it is more powerful with poor kidney function due to increased elimination time. SWIM recommends seeing a doctor about this - protein in the urine and other kidney signs can represent serious illnesses and should not be ignored. SWIM would not entirely discount the possibility that the piracetam could stress SWIY's kidneys, but SWIM doubts it.

[Rocketjones]

+1 to seeing a doctor. I think you should look at possibly having a preexisting condition. Any history of kidney disease, diabetes, stones?

[dexbud]

SWIM thanks SWIY for the advice... yes, kidneys have been damaged in the past (though it was organic/traumatic in nature). And yes, they have been tested, though only showed high specific gravity, nothing else out of normal range.

What about Sulbutiamine? Another board indicates it causes one's urine to smell foul, perhaps suggesting, again, the bulk of excretion duties falling on the kidneys... any advice here?

Also, SWIM is contemplating Centrophenoxine use, but this is not an immediate plan.

To good health,
SWIM

[snapper]

Just because kidney values are normal does not mean that your kidney function, faced with a large amount of work, may be slower or less efficient than a normal person's. SWIM would get checked out, be very careful with anything taken metabolized by the kidneys, and start with a low dose. For the record sulbutiamine did not change the smell of SWIM's urine.

[dexbud]

Thanks for your cautionary warnings, I assure you, after the damage absorbed from piracetam use (compounding my previous situation), my life totally changed.

I have heard sulbutiamine is actually healthy for you kidneys, can anyone corroborate this with experiential evidence?

dexbud added 16 Minutes and 5 Seconds later...

Healthy meaning, health-giving/restorative

[eche05]

Persistently foamy urine can be a sign of protein in SWIY's urine (proteinuria), which requires further evaluation. Large amounts of protein in urine may indicate a serious kidney problem.
In the circumstances of glumeruli (filters) damage in your kidney, proteins have less difficulty making it through. The protein most likely to show up in a urine test is albumin, what’s referred to as albuminuria.

Creating excess stress on SWIY's already weak renal system may aggrivate underlying conditions, possibly even edema. SWIM suggests scheduling a "routine urine analysis" with your doctor, as it may as well negate suspicion if previous drug use (if applicable).