Thoughts On Tramadol (synthetic Opiate)

[Fantasian]

Is it dangerous to combine the two?


Tramadol and codeine for example was what SWIM was thinking about.

[hotrod83]

anyone know anyone who has done klonopin and tramadonl. swim was wondering about the combined effects

[Jermcpicky]

SWIM says this combo works very well. SWIM prefers a Xanax/Tramadol combo, but thinks a klonopin one is close.

[Outlanderman]

I have mixed tramadol & hydro, tramadol & codeine and found
this to be OK, nothing special. The tramadol doesn't add much.



Anecdotally, it seems that heavy "traditional" opiate users get NOTHING
from tramadol. Opiate naive people seem to get a good,
hydrocodone like kick from it at 150mg - 300mg doses.



More than 300mg makes me kooky, sweaty, loopy, and can't shit for a fucking week. Don't do it, you'll pay.



This is one drug that seems to affect people in vastly distinct
ways. Some people get energy & euphoria, others a headache
and dysphoria. Weird.

[Fantasian]

200mg again last night and still loved it, it doesnt seem to give me a tolerance either.

[beena]

Originally Posted by fivemeoeyes

i've done tramadol a few times and i just dont like it, some ppl say
they feel great with euphoria and shit but it just doesnt seem to be
all that interesting for me. on opiates my favorite thing to do is to
write, either poems, lyrics or stuff along those lines i refer to it as
inspiration in a pill, its gets all my creative juices going with ideas
and feelings just stream out. However tramadol doesn nothing along
these lines for me, which sucks caus ei ahve an over abundance of this
drug. tramadol also has been reported to increase risk of seizures with
consumption as little as 250mg, i took 4 50mg pills (200mg) and i felt
veyr uncomfortable but i'm a small guy (110lbs.) so that makes alot of
difference as well. Basicly i think of tramadol as shit, and just
soemhting to do to past time, it does seem to mix wlel with other
opiates wether or not this helps the opiate effects or decreases their
effectivness i dont know ihavent experimented enough to see but they
did mingle well with making the opiate drug feel stronger i believe.
i'm just looking for some other peoples insight on thsi drug and what
they think about it, it seems their are alot of people that actually
like tramadol better than some real opiates which astonishes me i mean
the u.s hasnt even scheduled it yet. another thing i hate about
tramadol is that its full effects can take up to 2 hours to fully peak.
which sucks i hate waiting.

SWIM gets up in the morning with her head always spinning. The best way to describe this feeling is its like her brain is loose in her head and as she moves it bangs against the side of her head. SWIM knows this is tramadol withdrawal. SWIM has to take 200mg (or 4 50mg pills) first thing in the morning then return to bed for an hour until the pills kick in. She usually falls asleep and then bang on an hour (when they kick in) she wakes up feeling exuberant: really happy and basically 'full of beans'. SWIM has been addicted to tramadol for a while now and wishes she didn't have to go through this routine every day. She would not reccommend that anyone start using Tramadol on a daily basis or put themselves at any risk of getting addicted. SWIM started using them because she suffered with depression, but can't take normal SSRI anti-depressant drugs. She found that Tramadol worked effectively as an anti-depressant (and to be honest, despite being addicted to them and having to take them they really do still work). SWIM has often taken other opiates like morphine, codeine, fentanyl, etc and has taken heroin too. She much prefers these other opiates to tramadol. SWIM has recently started a creative writing course at university. SWIM takes these other opiates recreationally and only recently (since starting this course two weeks ago) she discovered that opiates really do help her write and think creatively. SWIM is going to continue using Tramadol as an anti-depressant rather than for any palliative reason for pain or recreationally, and will stick to occassional morphine use for recreational fun and as a writing aid.

[samuraigecko]

For those whom have taken oter opiates recreationally Tramadol is going to be more than a disappointment.

Tramadol is not even really an opioid.
The quick low down on what makes an opiate / opioid is this-
Any drug which is either derived from, semi or fully stynthetic from Opium poppy.

Tramadol cuts itself out of that class all together except for the fully stynthetic part. If the Tramadol molecule was modeled from something from Opium poppy, which it ISNT.

Tramadol itself has almost no mu-opioid affinity. Tramadol needs to be metabolized by the liver (in a simmilar way to Codeine) to produce the quasi-opioid it is known for (D-Methyl Tramadol) which DOES have an affinity to mu-opioid receptors but is a much smaller affinity than other real opiates.

The long and short of it is, people whom have not done much in the way of strong opiates may get a decent feeling from it, the others whom have done alot of REAL opiates will probably feel nothing at all because they are used to a feeling that the affinity of Tramadols metabolite just cannot reach.

Although others disagree the fact remains that Tramadol has more in common with SSRI, NADI and MOA drugs than with any opiate.

just an opinion

[Paracelsus]

Nadi? Moa?

[samuraigecko]

Noradrenalin reuptake inhibitors and Moazamine drugs, Sorry SWIyou may have a different reference for these drugs in SWIyour country and one should have thought of that.

Hope this has been of help

[Paracelsus]

Ah, then it's NARI. The correct category for tramadol (regarding its effects on monoamine reuptake) would be SNRI (serotonin-norepinephrine reuptake inhibitor), since tramadol is not a SSRI (it is not a selective serotonin reuptake inhibitor because it also inhibits NE reuptake). But what are moazamine drugs?

[samuraigecko]

Originally Posted by Paracelsus

But what are moazamine drugs?

Just typo . . . SWIM is very tired. Meant monoamine as SWIY suggested. One was under the impression that Tramadol was selective in its SRI capabilities from what one has read, sorry if one was mistaken.

[Jermcpicky]

MonoAmine Oxidase Inhibitors (MAOIs) are what SWIT's talking about. They raise the levels of almost every neurotransmitter but typically serotonin and norepinephrine more than the others. They are usually thought to be one of the last resorts for treating depression because the user's diet has to restrict anything that contains tyramine in it (cheese, beer, certain types of bread, and definitely certain dietary supplements) because the tyramine will release a large amount of norepinephrine at once whilst the MAOI will prolong the action of that norepinephrine and the user could die from a hypertensive crisis or stroke/heart attack, ect...

[Paracelsus]

What does the fact that tramadol is a monoamine say? Many drugs are monoamines, morphine and its derivatives included.

Tramadol is not a MAO inhibitor.

[samuraigecko]

Never suggested that it was a MAO just said it "has more in common with"

Just suggesting that it has more in common with anti-depressant drugs from all 3 similar actions than it does with opioid drugs especially with its small mu-opioid affinity (even with the metabolite). One knows that it is classed this way (as an opioid) and one also knows that it can be a good pain killer for those whom it works on (not many in ones experience) but in SWIMs own opinion it will never be an opioid, in other medical chems and bio-chems eyes it is not an opiate either. It is of much debate within those communities.

[Jermcpicky]

Chemically, morphine is a monoamine, but if you look at its structure, morphine has many more rings than say dopamine, which only has one ring. The monoamine oxidase enzyme that the MAOI drugs are designed to inhibit are nothing like the inihibitor that would need to be designed to inhibit the enzyme that metabolizes morphine, UDP-Glucuronosyltransferase-2B7, or UGT2B7. Again, he never said tramadol was a maoi. Please read more carefully because we're putting time into this discussion and so should you.