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  #1  
Old 20-01-2009, 13:32
cybergenesis cybergenesis is offline
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Questions about plugging vs oral

Usually Swim gets oxycontin, but this time it seems likely Swim shall be getting some morphine tablets.

Swim doen't like the idea, but if its the most efficient route (besides injecting) then Swim will consider plugging them.

1. Is it true you MUST break up and dissolve a pill? What about if the pill is a timed released type? Just cause Swim will have to get hold of a syringe to plug it. If Swim didn't have to break up the pill Swim would just shove the pill in

2. What does Swim ask for at a chemist to use as a syringe to plug morphine tablets? Swims never bought anything at all like this, dont know the name.

3. What is the bioavailibility via plugging? What is the bioavailibility with oral?

Thanks for anyone that can answer these questions.

Last edited by cybergenesis; 20-01-2009 at 15:38.
  #2  
Old 20-01-2009, 14:22
phatassone phatassone is offline
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Re: Questions about plugging vs oral

The oral BA is 30 to 50% i think and the anal BA is 40 to 60% but plugging also kicks in a lot faster...

you should ask for a syringe with a removable needle... or some meds come with needless syringes to measure out quantities...
  #3  
Old 20-01-2009, 15:12
MEKONE MEKONE is offline
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Re: Questions about plugging vs oral

By just shoving the pill in there you risk the chance of your body expelling it naturally due to the muscles.Another thing is that it probably wont completely disolve,will take a LOOOONG time to do so,and there is no sure way of measuring how much SWIY's body really absorbed(Remember analy the behaviorability is HIGHER as SWIY will be bypassing the liver).SWIY's best bet is a needle less syringe,which can me obtained with some OTC meds and is used as a ML. measuring tool.Good Luck!!
  #4  
Old 20-01-2009, 18:04
Fix Fix is offline
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Re: Questions about plugging vs oral

AFOAF plugged it and didnt notice much of a result. Holding in your mouth is probably the best way to do it, ground up finely to increase surface area, and the warmth of your saliva should dissolve it into a liquid state. There are lots of cheek and tongue tissue to absorb the good stuff right into your bloodstream. What doesn't dissolve in 5-10mins will eventually be absorbed in your gut. Its best this way as it avoids loss of goodness thru your digestive enzymes. I think only 30% or something actually gets thru when swallowed. Another nice thing to do is to have a sweet cup of coffee or tea afterwards... helps with the taste and the sugar and heat will also help speed up transfer of goodies through the protein layers.
  #5  
Old 21-01-2009, 00:17
MEKONE MEKONE is offline
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Re: Questions about plugging vs oral

Dissolving pills in ones mouth(especially sub-lingually)is one of SWIM's prefered method especially when it comes to Opana(Oxymorphone).SWIM feels it is absorbed quickly like stated above due to the soft tissues in the mouth and especially under the tongue which is why nitro is administered in this manner to heart pts..


Quote:
Principle
The principle behind sublingual administration is simple. When a chemical comes in contact with the mucous membraine beneath the tongue, orbuccal mucossa, it diffuses through it. Because theconnective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first pass metabolism" in the liver before entering the general circulation.
Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances, such as salvinorin A.
Substance
Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical. Based on these properties, a suitably soluble drug may diffuse too slowly through the mucosa to be effective. However, many drugs are much more potent taken sublingually, and it is generally a safer alternative to administration via the nasal mucosa. Many people are forced by the high cost of pharmaceuticals to split their pills and take them sublingually. One drawback, however, is tooth discoloration and decay caused by long-term use of this method with acidic or otherwise caustic drugs and fillers.
  #6  
Old 21-01-2009, 04:36
cybergenesis cybergenesis is offline
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Re: Questions about plugging vs oral

Are you people saying swim can do morphine sublingually? Cause yes I'd definably prefer to do this if it works.
  #7  
Old 21-01-2009, 12:20
Fix Fix is offline
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Re: Questions about plugging vs oral

I can say that without a doubt Morphine can be taken sublingually just like subutex (make sure you chew it up or even better crush to a fine powder first using the back of a spoon or place it in a sheet of paper, fold and then scrub with a back of a credit card to end up with a white fine powder. Extended-Release Capsules which contain contin waxes etc are overcome by doing this because they also dissolve. Be careful though, your dose will come on quicker, faster and stronger than if taken orally and swallowed whole. Also swim finds this puts up their tolerance faster than normal oral methods. Brief answer: YES.
  #8  
Old 21-01-2009, 15:31
MEKONE MEKONE is offline
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Re: Questions about plugging vs oral

Quote:
Originally Posted by Fix View Post
Also swim finds this puts up their tolerance faster than normal oral methods. Brief answer: YES.
SWIM can definately say this is true about tolerance,it is built up much more quicker this way.SWIM has done this method for years and has noticed a rapid increase.As stated above make sure SWIY starts off with a lower dose and then adjust as needed.Stay Safe,Good Luck!!

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bromazepam, morphine modes of administration, opana, plugging

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