Oral use - Prolonged Release Tablets

[drguildo]

SWIM recently came across some 120mg dihydrocodeine tablets (DHC Continus made by Napp). Trouble is they're prolonged release.

Is there any way around the prolonged release mechanism? SWIM read that chewing these kinds of tablets worked but wanted to check here first.

Thanks.

[InTheCity]

Im sure just crushing them up or even just breaking them in 2 defuncts the whole prolonged release bit.

[drguildo]

SWIM reports he just took one and says that for something that's not meant to be chewed they're very easily chewed.

drguildo added 68 Minutes and 17 Seconds later...

SWIM says he took it over an hour ago and isn't feeling anything.

SWIM has read in various places that dihydrocodeine has an equal to greater effect than codeine, but SWIM usually takes 120mg (4*30mg) of codeine and it's much, much better than this.

Does anybody have any idea what's going on?

[InTheCity]

Did SWIY just chew it and swallow it with or without a glass of water to wash it all down?

[drguildo]

Originally Posted by Synic03

Did SWIY just chew it and swallow it with or without a glass of water to wash it all down?

SWIM says they chewed it up and washed it down with some lemonade having waited about 3-4 hours after eating. SWIM is feeling a little bit now but says it's not what they feel with the equivalent dose of codeine; not as strong and not as nice.

SWIM did a bit of searching and saw something about a "CRUSH RESISTAN DELAYED-RELEASE DOSAGE FORM" [sic]. However, SWIM can't imagine why they would write in the "instructions" not to crush/chew the tablets if that form was being used.

[DHCletsmeBe]

Originally Posted by drguildo

SWIM found some more evidence supporting his "prolonged release despite crushing" hypothesis here. Unfortunately he hasn't found a corresponding way around it.

Is swiy going to try the washing soda method described in that thread? swim is getting these exact same DHC pills soon and he's getting worried the time release cannot be defeated

[DHCletsmeBe]

Swim should be getting his DHC continus 120mg within a couple days so he is formulating a plan to try the washing soda idea. The guy who came up with it sounded pretty knowledgeable so I'm just going to trust him. So here it is.


If swiy can recommend better/more exact measurements that would be great too:

1. crush 2 120mg dhc pills, then dump in a cup
2. add 1 tablespoon arm & hammer washing soda
3. cover the mixture with some water and stir it around good.
4. Let sit for 3 hours.
5. Add lemon juice to neutralize, stop adding when the CO2 bubbles cease.
6. Drink nasty crap.
7. Hopefully survive.

The theory behind this:

Some drugs are made time release by getting them to form salts of acids bound to long polymer chains; they're similar to ion exchange resins in water purifiers.

To release the drug, you have to put it into an alkaline soln., in order that something like a sodium ion can replace the drug, setting the drug molecule free in the process. Sodium carbonate soln (washing soda) is strong enough, but it'll still take time (at least a couple of hours). Don't use large volumes though, as you'll have to neutralize it with tartaric acid, or lemon or lime juice if you want to kill the taste (washing soda soln is alkaline enough to do some damage if it isn't neutralized).

Putting it into acidic soln will only partially extract the drug (because two acids are competing to form the salt with the drug). That's how it becomes time release in the gut

Thanks in advance for any help swiy can give!

[yaba]

Swim thinks that the prolonged release is a lot better then the instant release.
For example swim things 120mg PR feels a lot stronger then 210mg IR or even more.
Don't know why this is even a friend of swim thinks the same.

[DHCletsmeBe]

Originally Posted by yaba

Swim thinks that the prolonged release is a lot better then the instant release.
For example swim things 120mg PR feels a lot stronger then 210mg IR or even more.
Don't know why this is even a friend of swim thinks the same.

Wow very interesting. Swim says he maybe will try 240mg crushed first before messing with the washing soda (120mg just seems too low and its a waste to redose of course). He's assuming swiy crushes the pill first? And are these dhc continus by napp or are they perhaps panlor, which is supposedly the best?

[drguildo]

Originally Posted by yaba

Swim thinks that the prolonged release is a lot better then the instant release.
For example swim things 120mg PR feels a lot stronger then 210mg IR or even more.
Don't know why this is even a friend of swim thinks the same.

Very strange. SWIM has only tried PR so can't compare it to IR DHC, however SWIM says in terms of the "high", he doesn't think the 120mg PR even beats the equivalent dose of codeine and DHC is supposed to be "stronger" than codeine.

However, for longevity, 120mg PR is awesome. SWIM takes 1 or 2 of them in the late morning/early afternoon and feels good for the rest of the day.

[DHCletsmeBe]

Swim got his new dhc today woooooooooooooooooooot!!!!!! He's very happy. He will try 240mg crushed tonight and report back.

[yaba]

Swim never crushed the PR but he had lots of 30mg IR ,and only had the PR a few times. And he thinks 240mg PR beats 360mr IR by far !

The high of the IR seems to be of a very short time and doesn't feel as good as the PR.

The PR takes one or one and a half hour to start working and comes on slower but last a lot longer (think 4-6 hours of peak) and the feeling reminds swim of heroine.

The IR comes on 30-45min and last a couple of hours at best for swim, and feeling doesn't compare to the PR. When swim uses the IR he will need to have a drink with it (not advising to do the same !!) to make it go that bit further.

While he doesn't want to drink with the PR ! Unfortunately he couldn't get the PR (except for a few times) and he could easily get the IR quite cheap to !! In large enough quantity (he bought 60-80 at the time.) That was then his source is in prison now.

The withdrawal wasn't nice, not as bad as heroine but still not fun ! Keep that in mined...

Swim can't speak for everyone as the one persons medicine is the other persons poison, but for swim and one of his friends, they both have experience with dihydrocodeine PR, IR and codeine.

PR beats the rest !!!!!

[DHCletsmeBe]

Originally Posted by yaba

Swim never crushed the PR but he had lots of 30mg IR ,and only had the PR a few times. And he thinks 240mg PR beats 360mr IR by far !

The high of the IR seems to be of a very short time and doesn't feel as good as the PR.

The PR takes one or one and a half hour to start working and comes on slower but last a lot longer (think 4-6 hours of peak) and the feeling reminds swim of heroine.

The IR comes on 30-45min and last a couple of hours at best for swim, and feeling doesn't compare to the PR. When swim uses the IR he will need to have a drink with it (not advising to do the same !!) to make it go that bit further.

While he doesn't want to drink with the PR ! Unfortunately he couldn't get the PR (except for a few times) and he could easily get the IR quite cheap to !! In large enough quantity (he bought 60-80 at the time.) That was then his source is in prison now.

The withdrawal wasn't nice, not as bad as heroine but still not fun ! Keep that in mined...

Swim can't speak for everyone as the one persons medicine is the other persons poison, but for swim and one of his friends, they both have experience with dihydrocodeine PR, IR and codeine.

PR beats the rest !!!!!

Despite being a relatively weak opiate (opioid? whatever.) swim agrees codeine withdrawals suck pretty hard. Depending on swim's mood he may try his new dhc tomorrow morning because he doesn't want to be up all night. Swim cannot sleep at all while high on dhc. And if 240mg PR really beats 360mg IR then swim will be up all night lol.

[yaba]

Please let swim know swiy experiences.

And just seen your question which is the best, it shouldn't make any difference as 30mg IR or 120mg PR should be exactly what it says !! (As the active ingredient)

Swim is in the UK and the dhc comes from the local pharmacy and is made by Bristol pharmacy UK. (swim thinks if he remembers it right) The controls are very strict in the UK so its exactly what it says.

Places like Pakistan, India, South America, etc.. The controls might not be that strict.. And swim heard story's of weaker meds over there...

[DHCletsmeBe]

10 AM EST: Swim chews 2 120mg PR pills. And holy shit, that was the most disgusting crap he has ever tasted. Washed it down with water, making sure none got stuck in his teeth. It took all his strength not to throw up, (he usually gets IR pills and just swallows them whole). First he did listerine mouthwash to try to kill the taste, that didn't work. Then he grabbed the nearby bag of cheetos and took a small handful, that didn't do anything. Then he brushed his teeth and that actually got rid of 90% of the taste thank god. Can't edit yet so I will post again when I feel something.

DHCletsmeBe added 27 Minutes and 40 Seconds later...

Did I say when I feel something? I mean when swim feels something. And he's feeling something now but it ain't euphoria. More like a general fuzziness, maybe a hinting of nausea.

DHCletsmeBe added 18 Minutes and 59 Seconds later...

Its kicking in more now, more nausea for sure. Laying down solves it. So far this is more potent then swim had expected for sure.

DHCletsmeBe added 4 Minutes and 47 Seconds later...

Swim discovered he is pinned, as he had suspected.

DHCletsmeBe added 12 Minutes and 14 Seconds later...

Swim ate a medium sized meal. Shouldn't make any difference.

DHCletsmeBe added 5 Minutes and 42 Seconds later...

Swim's feeling pretty good laying down on the couch now. Euphoria setting in. Next report in an hour or 2.

DHCletsmeBe added 151 Minutes and 41 Seconds later...

Not a whole heck of a lot for swim to report at this point. He's just very chilled, very relaxed, watching tv. These dhc pills do appear to be prolonged release despite crushing, not that that is necessarily a terrible thing but the more intense high swim can get from IR is not there. In the future swim may do 1 120mg PR + 2-4 40mg IR, seems like that would be a great combo. One more report when the experience ends.

DHCletsmeBe added 203 Minutes and 3 Seconds later...

Swim can still feel it at this point. Basically, it lasts all day. Swim is impressed. Great for anxiety relief. So yes, they are PR despite crushing. If swim ends up trying the washing soda method some day I will report his findings.