Drug info - Hu-210

[enquirewithin]

HU-210 is a synthetic cannabinoid that was synthesized around 1988 in the group of Prof. Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.[1] HU-210 is the (-)-1,1-dimethylheptyl analog of 11-hydroxy-Δ8-tetrahydrocannabinol, in some references it is called 1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol. The abbreviation HU stands for Hebrew University.

Per a 2005 article in the Journal Of Clinical Investigation, HU-210 with daily high doses over a few weeks stimulates neural growth in rats' hippocampus region, the opposite effect of drugs like alcohol, nicotine, heroin, and cocaine. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.[2]

HU-210, alongside WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.[3]

HU-210 is a potent analgesic with many of the same effects as natural THC. This means that HU-210 could potentially be used in medicine as an alternative to medical marijuana, however its much stronger and longer lasting effects compared to those of THC could make appropriate titration of dosage difficult. Also because HU-210 is a CB1 full agonist as opposed to THC which is a partial agonist, the sedative effects of HU-210 are much more prominent, meaning that while fatal overdoses of THC itself are virtually impossible[1], they would be possible with HU-210.

http://en.wikipedia.org/wiki/HU-210

Possibly an ingredient of spice, etc.

Reputation Comments on this post:

Thanks for sharing.

[spatchcock86]

This is getting silly now...
Apparently they've identified CP-47,497 as an ingredient in Spice as well.
First JWH-018, then Hu-210, and now this.
Which one is it?
Or is it a mixture of all three?

BKA identified the main ingredient

Not herbal essence, not Räuchermischung: In the fashion drug Spice stuck synthetic cannabinoids, so far no laboratory has discovered. It reported the Bundeskriminalamt - and warns again before overdosing and addiction.

Fashion Spice drug is stronger and even more unpredictable than marijuana and hashish effect. The drug contains as the main ingredient is the synthetic cannabinoid CP-47497 ", as the Federal Criminal Police Office in Wiesbaden on Monday announced. This substance resembles the main ingredient of the cannabis plant, THC, but have a lot higher pharmacological potency.

So far mostly as a sole active ingredient called Spice substance "JWH-018" was in joint investigations of BKA and the University of Freiburg Institute of Legal Medicine, only in some samples in low concentrations have been found, investigators said. Only in other Spice-like herb mixtures was "JWH-018" as the main ingredient has been included. SPIEGEL ONLINE had already last December on the research of a Frankfurt pharmaceutical company reported that JWH-018 was identified.

"The high efficacy of the synthetic cannabinoids, as well as the uneven distribution of active ingredients in the herbal mixtures carry the risk of overdose after smoking Spice and similar products," warned the Bundeskriminalamt. The addictive nature is at least comparable to that of cannabis. In addition, through the combustion process when smoking and redeployment of the substances in the body of potentially toxic and carcinogenic products are formed.

With current tests can not be verified
The federal government had already announced the end of December, production, trade and possession of drug ban fashion. Previously, this was already in Switzerland and the Netherlands. According to the Federal Drug Officers Bätzing will Sabine Federal Health Minister Ulla Schmidt (SPD) a Eilverordnung Narcotics Act to sign. "This is Spice from circulation," said Bätzing. Bundestag and the Bundesrat must be within one year a long-term ban on the launch.

Officially, Spice as "Räuchermischung to Beduften of spaces traded. On the Internet and in so-called head shops, finds it hot cakes.

The effect of Spice is euphoria and enthemmend first, then as müdemachend described. Consumers are ultimately "zugedröhnt". With the current drug testing Spice is not detectable.
The Federal Institute for Risk Assessment was initially not able to explain why it is similar to a glittering effect comes when the smoke inhaled by Spice. Because it took place in the shiny metallic bags a "mixture of eight different plants" with picturesque names like lion's tail Siberian, Indian Warrior or blue lotus flower.

[enquirewithin]

It would appear to be a mixture, from what has been published. Where did this 'glittering' article come from?

[spatchcock86]

The original article is from a German news website.
I would post the link but I'm unable to as I've not reached 50 posts.

[Alfa]

Originally Posted by enquirewithin

It would appear to be a mixture, from what has been published. Where did this 'glittering' article come from?

The duration of hu-210 does not add up with spice. Nor does the duration of JWH-018. My bet is on incompetence.

[spatchcock86]

Originally Posted by Alfa

The duration of hu-210 does not add up with spice. Nor does the duration of JWH-018. My bet is on incompetence.

Yea, I can't see it being hu-210 myself.
It's extremely unstable and has to be stored at very low temps.
Sounds like media sensationalism to me.
Just so they can put "Spice is 100-800 time more potent than cannabis".

[awakening]

CP 55940 possibly? SWIM finds it similar to smoking blends he's tried tho he hasn't tried SPICE specifically

[bravedog]

Originally Posted by Alfa

The duration of hu-210 does not add up with spice. Nor does the duration of JWH-018.

What are duration profiles for HU-210 ,CP-47,497, JWH-018, and Spice? Thanks

[RaverHippie]

Spiegel - http://www.spiegel.de/wissenschaft/m...602072,00.html (german version)

our compadres over at the forum analogous to cyanlight, posted the same article in a discussion of jwh-018.

[Toma]

What would be the mechanism causing death in cannabinoid overdose?

[spatchcock86]

Originally Posted by Toma

What would be the mechanism causing death in cannabinoid overdose?

I would assume with the less selective CB1/2 agonists that strong CNS depression leading to unconsciousness and respiratory failure could be a possibility.
Some of the synthetics appear to bind to CB receptors in the lower regions of the brain unlike cannabis, which could cause problems mixed with other CNS depressants, or even by it's self.
I'm guessing they also have the potential to increase GABA levels to a much higher extent than that of Cannabis as well.

[mictihtoya]

Originally Posted by spatchcock86

I would assume with the less selective CB1/2 agonists that strong CNS depression leading to unconsciousness and respiratory failure could be a possibility.
Some of the synthetics appear to bind to CB receptors in the lower regions of the brain unlike cannabis, which could cause problems mixed with other CNS depressants, or even by it's self.

THC and I believe most of the other synthetic cannabinoids being discussed are only partial agonists at CB1 receptors, but HU-210 is a full agonist.

The 'lower regions of the brain' meme you have there comes from the much discussed fact that CB1 receptors are expressed in very low concentrations in the brain stem. THC is a partial agonist at these CB1 receptors too. So is JWH-018. HU-210 is a full agonist at these receptors and it has been theorized on internet forums that this means there is a possibility that HU-210 overdose could come from respiratory depression. It was only recently shown that CB1 agonism in the brain stem leads to respiratory depression.

Your use of the term 'selective' doesn't seem to apply.

[dekadenzia]

JWH018 and Hu210 are both full agonists at CB1 and CB2 receptors. The only difference is the Ki value which is much lower for Hu210. This is where the extreme potency comes from. Smoked JWH or Hu210 has no different action compared to oral intake. As we work in the lab with these substances I was lucky to try ACEA (potent full CB1 agonist) along with Hu-210. I applied it like the formulation present in the THC medicine Sativex. Potency is really about 400 times that of THC ( I weighed in 200 µg) and the high is almost too intense.

Reputation Comments on this post:

Very interesting information. Keep posting!

[Toma]

Originally Posted by dekadenzia

JWH018 and Hu210 are both full agonists at CB1 and CB2 receptors. The only difference is the Ki value which is much lower for Hu210. This is where the extreme potency comes from. Smoked JWH or Hu210 has no different action compared to oral intake. As we work in the lab with these substances I was lucky to try ACEA (potent full CB1 agonist) along with Hu-210. I applied it like the formulation present in the THC medicine Sativex. Potency is really about 400 times that of THC ( I weighed in 200 µg) and the high is almost too intense.

Since you work with them, are you aware of any toxicity studies that have been done on them? Regarding the speculations of respiratory depression on overdose or of carcinogenicity of the naphthoyl containing cannabinoids?

[Alfa]

Originally Posted by Toma

Since you work with them, are you aware of any toxicity studies that have been done on them? Regarding the speculations of respiratory depression on overdose or of carcinogenicity of the naphthoyl containing cannabinoids?

The massive amounts of smoking blends that have been consumed in the last 5 years, without anyone dying from them, does eliminate the risk of respiratory depression(within normal doses). You will not find a better study than that.

Regarding murphy's thesis of naphthoyl carcinogenicity; it seems to me that mouse99's ADME studies rule that thesis out completely. I would like to get more opinions about that here: JWH-018 (Spice) ADME Toxicology Studies & Discussion

[Toma]

Originally Posted by Alfa

The massive amounts of smoking blends that have been consumed in the last 5 years, without anyone dying from them, does eliminate the risk of respiratory depression(within normal doses). You will not find a better study than that.

Regarding murphy's thesis of naphthoyl carcinogenicity; it seems to me that mouse99's ADME studies rule that thesis out completely. I would like to get more opinions about that here: JWH-018 (Spice) ADME Toxicology Studies & Discussion

Has it been established that these smoking blends contained full agonists? They may have been based on partial agonists.

As regarding mouse's studies, they may rule out carcinogenicity if they are indeed legitimate. But since they were posted anonymously and have not been confirmed, I was just curious whether there were any other studies done.

There are legitimate reasons why these studies would be posted anonymously and the dangers of these substances are speculative in the first place, but I was just looking for a second perspective.

[Alfa]

If there are more studies, then that would be mighty interesting.

[Euphoric]

The March 2009 DEA Microgram newsletter says that spice contains HU-210. Furthermore, it says that HU-210, smoking blends containing it, and similar cannibinoids are controlled in the US.

[enquirewithin]

Not good news for smokers!

[msimm]

@enquirewithin the way the analogue laws are in the US (and our approach to prohibition in general) this should come as no surprise. Reading through the past year or twos worth of bulletins even turns up some more mundane seizures, for things like Kanna (which I don't think is controlled, but was seized and analyzed). Ordering potentially prohibited merchendise from abroad the risk is seizure (as with pharmaceuticals; which results in so-called lover-letters) but selling the same materials within the US is where things get more dicey and the risk is prosecution (see JLF Catalog for a little history).

[Alfa]

http://www.drugs-forum.com/forum/loc...51&linkid=7540

Analysis from samples bought from vendors in the UK contained the following:

EX-ses, spike99 and spicey xxx contain hu-210, jwh-018, cp47497

[gmeziscool2354]

hu-210 is a schedule one drug in the USA. i haven't actually taken the time to look it up, so i'm willing to take the hit if this is wrong, but it says so on the wikipedia site.

anyway, i believe the seizure of spice blends by the DEA in detroit (?) was due to the fact that they contained a schedule 1 narcotic and were being distributed as legal 'herbal incenses'

[Alfa]

This analysis again shows that spice does not contain hu-21. EX-ses, spike99 and spicey xxx do.