Pharmacology - Bioavalibility Question - Opana

[award11]

SWIM has used opiates for a long time and has a very high tolerance. He recently came across some Opana 20mg ER and simply chewed them up like he has done oxcontin in the past. After not getting any effect from them, he researched and found that they only have about 10% BA. This bein the case, why are these pills so popular and highly sought after ? How can a pill with such poor BA have such good pain relieving qualities ? I now know now that the preferred route of administration is snorting but what about all the people out there that take them as prescribed, do they just not get much reief ? Just because a medication has a low BA does that make it "not as good" or not as effective for management of pain ? Any enlightenment would be greatly appreciated.

[RoboCodeine7610]

Well first of all the dosage for a non-opioid tolerant patient who just needs some pain relieve is a lot lower than a recreational dose.When establishing a therapeutic dose for a drug it's bioavaliability is taken into consideration since human trials where done where they established the best oral dose for pain relieve.

So if you where to IV the stuff, it would probably be 90% stronger since the bioavaliability would be about ~100%.

[PsychoActivist]

SWIM doesn't know very much about Opana in general other than the fact that it's Oxymorphone which means it's basically to Hydromorphone (Dilaudid) As Oxycodone is to Hydrocodone. He has no experience with Oxymorphone but he would assume plugging would be a much safer ROA than IV and produce a much higher BA than oral use.

Maybe next time SWIY should trying crushing one up and mixing with a small amount of water (if it's water soluble) and using an oral syringe for anal injection.

SWIY seems to be correct on the oral BA. Wiki says 10% as does RXList.

[Daytona71]

SWIM has a choice of either hydromorphone or oxymorphone and so far it is the hydromorphone by far. SWIM asks for the brand name of the hydro and that mixes so nice with water while even the IR oxymorphone leaves behind a lot of unneeded gunk. SWIM saw a thread here about ER being "solved" for thge direct route and the bioavailability has no bearing on the effectiveness when the chemical in question is many times stronger than morphine.
A dozen a day, chosen my way. Unless there is some revelation on administering the oxymorphone it is back to hydromorphone.

[static_vodka_420]

well swim read somewhere on this forum and in his research that ethanol increases the bioavailability of opana and most people who take there medication wash it down with a cold one in swims area and if its not theyre medication theyre snorting it which has a higher bio availability.

[Daytona71]

SWIM went back to Hydromorphone. Unfortunatly SWIM must have tolerance as SWIM started using his meds the most direct route.Using four 8mg. tabs of brand name Dilaudid withnot much happening. Took 3-4 barrels as they are sugar works and not large.Still 4 done within 5 minutes should send SWIX's to the ER and no euphoria or any feeling of consequence. SWIM read about a very experienced user whowas familiar with H doing 4mgs. of Hydromorphone and being rocked. Tolerance builds quickly as one 8mg. tab did get SWIM lying downonce.
Oxymorphone is junk as supplied, even the IR version. 2-3 10mg. tabs done in succession did even less than the Hydromorphone by a long shot. Adding alcohol increases the bio to around 70% from the 10% when eaten so that is the danger. A SWIY may be usedto20-30mgs. of IR orally and has a few and quickly OD's. SWIM is surprised the warning is not highlighted more than it is. This drug was taken off the market back in 1972 in the states as people would do anything to get it as it was only avbailable as an IV drug. SWIM believes that Hydromorphone is still the best and with 360 tabs a month along with 360tabs of 10mg.Methadone SWIM stays comfortable as long as no work is done. 60mgs.of Dextroamphetamine are given daily tio keep SWIM awake driving. No euphoria. A SWIY of SWIM's was visiting and did 7 tabs and it made SWIY normal, no euphoria, must be an age thing or perhaps the other downers affect the other meds, especially methadone.That lessens euphoria for certainof other opioids and probably the D-amps too.
A vacation is what is needed SWIM thinks for these to work as in the past. How long away from IV'ing hydromorphone is usually needed for use to ciontinue and efects go backto the beginning? Never the same, I know, chasing the "white smoke" as an old methamphetamine user told SWIM. SWIY's using huge amounts of methamphetamine(Desoxyn, is this taken off the market? It was expensive for some reason). Something likea half dozen 15mg. tabs at once, maybe more to where the user sees white smoke and nothing else. The SWIY in this story did the inj. and SWIY's jaw dropped and SWIY fellback into the chair, survived. Crazy stuff back in the day when these were so available. Apologies for getting off topic.
Oxymorphone may be great if 100% unadulterated but as is it is junk to SWIM. SWIM does not injest alcohol. If any SWIY does be careful, smart and safe!