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  #1  
Old 06-01-2009, 15:45
award11 award11 is offline
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Bioavalibility Question - Opana (oxymorphone)

SWIM has used opiates for a long time and has a very high tolerance. He recently came across some Opana 20mg ER and simply chewed them up like he has done oxcontin in the past. After not getting any effect from them, he researched and found that they only have about 10% BA. This bein the case, why are these pills so popular and highly sought after ? How can a pill with such poor BA have such good pain relieving qualities ? I now know now that the preferred route of administration is snorting but what about all the people out there that take them as prescribed, do they just not get much reief ? Just because a medication has a low BA does that make it "not as good" or not as effective for management of pain ? Any enlightenment would be greatly appreciated.

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this is an international forum - pls use drug names not brand names - "oxymorphone" not "opana"
  #2  
Old 08-01-2009, 00:53
RoboCodeine7610 RoboCodeine7610 is offline
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Re: Bioavalibility Question - Opana

Well first of all the dosage for a non-opioid tolerant patient who just needs some pain relieve is a lot lower than a recreational dose.When establishing a therapeutic dose for a drug it's bioavaliability is taken into consideration since human trials where done where they established the best oral dose for pain relieve.

So if you where to IV the stuff, it would probably be 90% stronger since the bioavaliability would be about ~100%.

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Excellent distinction between a therapeutic dose and a recreational one. Superb point made here.
  #3  
Old 08-01-2009, 00:58
PsychoActivist PsychoActivist is offline
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Re: Bioavalibility Question - Opana

SWIM doesn't know very much about Opana in general other than the fact that it's Oxymorphone which means it's basically to Hydromorphone (Dilaudid) As Oxycodone is to Hydrocodone. He has no experience with Oxymorphone but he would assume plugging would be a much safer ROA than IV and produce a much higher BA than oral use.

Maybe next time SWIY should trying crushing one up and mixing with a small amount of water (if it's water soluble) and using an oral syringe for anal injection.

SWIY seems to be correct on the oral BA. Wiki says 10% as does RXList.
  #4  
Old 20-09-2009, 12:56
Daytona71 Daytona71 is offline
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Re: Bioavalibility Question - Opana

SWIM has a choice of either hydromorphone or oxymorphone and so far it is the hydromorphone by far. SWIM asks for the brand name of the hydro and that mixes so nice with water while even the IR oxymorphone leaves behind a lot of unneeded gunk. SWIM saw a thread here about ER being "solved" for thge direct route and the bioavailability has no bearing on the effectiveness when the chemical in question is many times stronger than morphine.
A dozen a day, chosen my way. Unless there is some revelation on administering the oxymorphone it is back to hydromorphone.
  #5  
Old 06-10-2009, 06:02
static_vodka_420 static_vodka_420 is offline
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Re: Bioavalibility Question - Opana

well swim read somewhere on this forum and in his research that ethanol increases the bioavailability of opana and most people who take there medication wash it down with a cold one in swims area and if its not theyre medication theyre snorting it which has a higher bio availability.

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It would have been so preferable that you use the search engine regarding ethanol and bioviability.
  #6  
Old 06-10-2009, 15:59
Daytona71 Daytona71 is offline
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Re: Bioavalibility Question - Opana

SWIM went back to Hydromorphone. Unfortunatly SWIM must have tolerance as SWIM started using his meds the most direct route.Using four 8mg. tabs of brand name Dilaudid withnot much happening. Took 3-4 barrels as they are sugar works and not large.Still 4 done within 5 minutes should send SWIX's to the ER and no euphoria or any feeling of consequence. SWIM read about a very experienced user whowas familiar with H doing 4mgs. of Hydromorphone and being rocked. Tolerance builds quickly as one 8mg. tab did get SWIM lying downonce.
Oxymorphone is junk as supplied, even the IR version. 2-3 10mg. tabs done in succession did even less than the Hydromorphone by a long shot. Adding alcohol increases the bio to around 70% from the 10% when eaten so that is the danger. A SWIY may be usedto20-30mgs. of IR orally and has a few and quickly OD's. SWIM is surprised the warning is not highlighted more than it is. This drug was taken off the market back in 1972 in the states as people would do anything to get it as it was only avbailable as an IV drug. SWIM believes that Hydromorphone is still the best and with 360 tabs a month along with 360tabs of 10mg.Methadone SWIM stays comfortable as long as no work is done. 60mgs.of Dextroamphetamine are given daily tio keep SWIM awake driving. No euphoria. A SWIY of SWIM's was visiting and did 7 tabs and it made SWIY normal, no euphoria, must be an age thing or perhaps the other downers affect the other meds, especially methadone.That lessens euphoria for certainof other opioids and probably the D-amps too.
A vacation is what is needed SWIM thinks for these to work as in the past. How long away from IV'ing hydromorphone is usually needed for use to ciontinue and efects go backto the beginning? Never the same, I know, chasing the "white smoke" as an old methamphetamine user told SWIM. SWIY's using huge amounts of methamphetamine(Desoxyn, is this taken off the market? It was expensive for some reason). Something likea half dozen 15mg. tabs at once, maybe more to where the user sees white smoke and nothing else. The SWIY in this story did the inj. and SWIY's jaw dropped and SWIY fellback into the chair, survived. Crazy stuff back in the day when these were so available. Apologies for getting off topic.
Oxymorphone may be great if 100% unadulterated but as is it is junk to SWIM. SWIM does not injest alcohol. If any SWIY does be careful, smart and safe!

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Good safety advice about the risks of increasing bioviability.
  #7  
Old 26-01-2011, 23:22
herbalgerbals herbalgerbals is offline
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Re: Bioavalibility Question - Opana (oxymorphone)

SWIM takes the opana ER 5mgs.. started useing them after a 6month heroin bing *smoking/snorting* ONLY*, one IV attempt but thats it.. SWIM moved up to white china, and it seems snorting, eating, or even chewying doesnt get SWIM high at all! what gives.. SWIM has another doc. appointment in 1 week, and wants to get put on something else.. SWIM wants euphoria, not to Just feel well..
  #8  
Old 17-11-2012, 15:53
Opanaphile Opanaphile is offline
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Re: Bioavalibility Question - Opana (oxymorphone)

Quote:
Originally Posted by award11 View Post
SWIM has used opiates for a long time and has a very high tolerance. He recently came across some Opana 20mg ER and simply chewed them up like he has done oxcontin in the past. After not getting any effect from them, he researched and found that they only have about 10% BA. This bein the case, why are these pills so popular and highly sought after ? How can a pill with such poor BA have such good pain relieving qualities ? I now know now that the preferred route of administration is snorting but what about all the people out there that take them as prescribed, do they just not get much reief ? Just because a medication has a low BA does that make it "not as good" or not as effective for management of pain ? Any enlightenment would be greatly appreciated.
There are numerous misconceptions about oxymorphone, and it's also important to distinguish between the ER and IR formulations. One commonly addressed fact in Clinical Pharmacology articles in medical journals is that although 10% oral BA sounds low, other opiates including morphine have and oral BA of only 12-15% - however, there are many factors that are potentiators BA, it is the strongest IR opiate prescribed outside of a hospital, and even at a mere 10% oral BA, one gram of oxymorphone taken orally is equivalent or higher than 2 mgs of oxycodone taken orally.

As you touched on, BA is highest (it increases by 43%) using an intranasal ROA. It is the only opiate with a higher BA intranasally (oxycodone and hydrocodone, for example, have a lower intranasal BA. While this ROA provides the strongest and most immediate onset, the half-life of the drugs are cut in half, its physiological effects drop from ~4 hours to ~1.5-3 hours. Oxymorphone, however, not only increases in BA intranasally but has a faster onset, longer half-life, greater duration, increased euphoria, more efficacious analgesic properties, and greater overall potency. From a medical standpoint this ROA is presently one of the most effective and safe ROAs - empirical evidence that has prompted the development of what will be dispensed as a nasal spray.

However, if you prefer oral use there are ways to potentiate the oxymorphone and increase BA via an oral ROA as well. Because oxymorphone is less soluble with lipids, eating a fatty meal with an oral dose can boost BA up by 50% or greater. Additionally, cimetidine (e.g., Tramadol) potentiate the binding action of the oxymorphone thus increasing both BA and efficacy of analgesic properties.

Finally, I must stress that although alcohol consumption increases BA, it does so in an unpredictable, highly variable manner with potential to increase BA by over 270% - which is deadly. There are of course more ROAs and methods of increasing BA, but I'll leave it here. Opana is one of the strongest, most potent IR meds around, crosses the blood-brain-barrier more than so than other opiates, and due to a relatively stable state for several hours after it's peak in 30-60 minutes, it lasts the greatest amount of time at its peak strength. It can take a few days to build up in the bloodstream for some and will then be similarly efficacious. It is the most effective IR medication able to provide me any pain relief at this point, so if used correctly it should be similarly effective for anyone else.

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