Combinations - DXM tripping and Ecstasy (MDMA) use - risk of serotonin syndrome?

[ThaNewJimJones]

My friend is going to snort half a E pill and drink a big bottle of Robo. Also smoke hella weed. Is this safe???

[x2stpsfrmnowher]

MDMA and DXM is a very dangerous combo. Both of these drugs release amounts of serotonin. Mixing the two together could cause seretonin syndrome, possibly resulting in death. As a side note my friend did this after I told him of the risks, and he told me it was the worst feeling ever. He said it felt as if his brain was frying.

[thealmassi1]

SWIM tried a 600 mg dose of dxm this past friday and is due to take E the next friday at a concert with his friends. I have heard from certain ppl that this is nto a good idea since they don't mix well, but it is a week between each of them so i think i'll be ok but still unsure. And since this is my first time taking E, what dose is recommended? Some thoughts?/

[Paracelsus]

Yes, DXM is known to cause serotonin syndrome when combined with MDMA. I doubt there will be any problem if they are spaced out a week. Please look in the Ecstasy forums for dosage info.

[Digemlo]

DXM is a mild SSRI, and from overheard experience, serotonergics don't mix well with it.
But a week should be plenty of time.

[Graduisic]

I saw the thread in the root dissociatives forum about PCP and E, and there seemed to be a bigger discussion about DXM and E. SWII always thought this was a bad combination because they both messed with the serotonin system. SWII can say from his experience that the myth "DXM prevents sweating" is bogus, so what really are the dangers here?

[Pino]

Swim doesn't know about the sweating thing, but serotonine syndrome (with all the problems associated to it) and hypertension are possibilities.

[stefan22]

If swim takes 300mg dxm tomorrow morning, will swim be safe to candy flip on saturday night?

Like is the effects of lsd/ecstasy lessened due to dxm use few days before?
Works on same brain area?

^^Swims question^^

[Mutil]

Swim does NOT recommend taking Ecstasy within a week of taking DXM, and vice-versa. the effects will not be lessened, but MDMA + DXM = x-P (dead)

granted, taking E after DXM probably won't kill you, but are who wants to play that game?

LSD should be fine, in fact I think some people have reported experiences with the combination...

perhaps someone else could give you more information. I'm not sure how long one would have to wait to be 100% sure the DXM won't interact with the MDMA.

[drapes1125]

SWIM just bought some and the active ingredients say (in each 5mL):
DXM HBr, USP 15 mg. So what does Usp mean is it safe. and also SWIM rolled on four single stack x pills two nights ago then took two single stacks last night so would it be a good idea to use this tonight.(The second night SWIM didn't feel anything.)

[PsychoActivist]

Originally Posted by drapes1125

SWIM just bought some and the active ingredients say (in each 5mL):
DXM HBr, USP 15 mg. So what does Usp mean is it safe. and also SWIM rolled on four single stack x pills two nights ago then took two single stacks last night so would it be a good idea to use this tonight.(The second night SWIM didn't feel anything.)

USP stands for United States Pharmacopeia. They basically set standards for all prescription and over the counter medicines as well as some food and dietary supplements. These standards that they set are for the quality, purity, strength, and consistency of such products.

Basically all the "USP" means is that what you have is USP grade or USP approved. It just ensures the overall quality of the product. So what it is saying is that in each 5 ml teaspoonful it contains 15 mg's of USP grade Dextromethorphan.

The HBr stands for Hydrobromide. DXM in it's base form is not water soluble, so if it remained in it's base form there would be chunky stuff floating around in the cough syrup. By converting it to Hydrobromide it basically turns it into a salt(?) to make it soluble in water so that it is consistent throught the syrup. I'm not 100% sure on this so someone please correct me if I'm wrong, but from I remember reading I'm pretty sure thats how it works.

What SWIY has is an ideal product for use. Anything that has only Dextromethorphan in it as the active ingredient is ok.

SWIM also recommends that if you haven't already please read White's FAQ.

Reputation Comments on this post:

	nice advice
	good detailed answer about difference between USP and HBr

[DXMBunny]

Originally Posted by drapes1125

SWIM just bought some and the active ingredients say (in each 5mL):
DXM HBr, USP 15 mg. So what does Usp mean is it safe. and also SWIM rolled on four single stack x pills two nights ago then took two single stacks last night so would it be a good idea to use this tonight.(The second night SWIM didn't feel anything.)

do not take tonight or for quite awhile... swiy is risking high chances of serotonin syndrome... since MDMA acts on serotonin receptors and so does DXM in opposite ways and either way you shouldnt be doing to much activity to you serotonin receptors it makes for easy chance for Serotonin Syndrome!

You have the right stuff for swiy to take but if swiy did what you say then he is definitly way to close back to back to take these... be careful what you take after X anyways but especially this... X lingers in the system for quite awhile and is very very very unsafe to take with DXM!

Swim only hopes he caught Swiy in time to stop him!

Serotonin Syndrome

Please have swiy use the search engine and read about DXM and mixing!

[drapes1125]

Yeah SWIM read all about too much usage and everything.That's why SWIM asked. So about how long should SWIM wait to use this??And swim has a drug test wednesday anyone have any tips on how to pass??

[PsychoActivist]

SWIM would recommend SWIY wait at least 3 days to let everything else get out of his system.

As far as the drug test is concerned, what is SWIY worried about failing for? If it's the X it will almost certainly be out of his system by Wednesday provided he doesn't take anymore. If it's the DXM - they don't test for it in standard or even extended tests though on rare occasions it has been known to cause a false positive for phencyclidine (PCP) and/or Opiates. To be 100% sure SWIY could just wait till after Wednesday to use the DXM.

If there is anything else in SWIY system such as THC then he might be in trouble and may need to start thinking about buying a system cleansing product. This is something SWIM can't recommend for you as he has found nothing that works for him other than abstinence. He has however heard of some that work for others so if this is the case maybe someone else can help.

[Punkrocker11393]

I have a friend who is (very very) close to me.

He took 40 capsules of robo cough liquigels, about 2 weeks after he had ecstasy. This gave him a metalic taste in his mouth for half a week, and made him hallucinate for 3 days. All the while, his head felt like it was colapsing, he couldnt feel his legs or his mouth, and he wanted to off himself.

He got really depressed and realized that the thing that will kill us all in the end is whatever we've underestimated the most.
Just realizing this, made him afraid to sleep on the third day, believeing that he might die in his sleep if he were to underestimate the problems that were going on with his mind.

But yes... my (very very) close friend deffinately reccomends that you look into what you're doing and making sure you're safe.
Also, you sould surely check the reports on your ecstasy. Even still, you should assume it is cut with something unless you made it yourself.

And by the way, my (very very) close friend is also prescribed adderall, 20mg XR, which he takes every day, and he smokes alot of weed. This could possibly have something to do with the side effects.

Happy Highgets!

[drapes1125]

SWIM has only smoked like three bowls.The sure-gel method works, and he drank a little vinegar.SWIM only failed once and that was because he did it wrong.

[DXMBunny]

Originally Posted by drapes1125

SWIMs bad.

yes he is... swim does alot... but at least know one knows swims true identity and officials can not blame anything on someone they cant find! but they could use it against you...

So Swim it up! alright?

DXMBunny added 2 Minutes and 50 Seconds later...

also i agree that 3 days should be sufficient for swim but a week at least is best... of course more time is always safer... but the chemicals should be less if not at all active after a few days...

But also for the best trip it would be best to let swiy's serotonin levels return to normal which usually takes a few weeks... use some 5-htp supplements to help cut that time in half or less... they are a supplement that is the precursor to serotonin basically meaning your body turns it straight into serotonin... find it at your local vitamin at usually any store with a vitamin section! good luck and be safe swiy!

[Abuse]

I'm sorry but i have to call Bullsh*t. swim has done this many times and in higher dosages than swiy is talking about and has been fine...seriously half a pill and a bottle of Robo? the last time swim checked a bottle of robo was ~300mg. that aint alot

[tre2005be]

although i have no direct experience with this combination it is quite possible that swiy has already done this combination in pills swiy has took in the past without ever knowing it. there is one experience report on erowid about it http://www.erowid.org/experiences/exp.php?ID=2532.

[Nagognog2]

Mixing MDMA with DXM is absolutely contraindicated. This mix invites serotonin-syndrome - and can be potentially fatal.

[bewilderment]

Nagognog is right, it is potentially dangerous and not advised. But, I will mention that SWIM's spouse did this one night and reported a very intense and pleasurable experience. But, she then found out of the dangers and never repeated the experiment.

[jesusfreak666er]

swim was under the belief that this would induce seritonin syndrome, swim would highly recomend not doing this mixture.

[Bajeda]

In addition to seratonin syndrome (which is bad enough in its self), swim notices when he does larger doses of DXM or when he mixes DXM with substances other than cannabis he finds his body temperature rising. Sometimes swim gets a very 'E' like feeling from DXM in or inbetween one of the plateaus, though its much hotter even. Swim thinks overheating could also be a concern if swiy attempted to combine the substances.

This looks like a combination not to experiment with.

[Forthesevenlakes]

as stated above, this combo is dangerous due to the potential for serotonin syndrome and simply because of an elevated heart rate. E plus any stimulant is very bad news. also like baj said, dxm can produce intense feelings of empathy and joy on its own...swim thinks that the first few dxm trips can produce more empathy than E even, so why bother trying to make that feeling stronger? just enjoy each one on their own. hope swiy has some fun and safe experiences on each though!

[Akewstick]

Alright here's a question from SWIM to you all:

How long should he wait after Es to do dex? just as long as the effects of E last? Is it the same the other way around?

Could he do dex one night and E the next? Could he do it the other way around?