Opinions - upping the ante (redosing LSD after 3 hours)

[Tong1]

swim was wondering, if his pet ferret was already a little wasted and had consumed his first potion about 3 hrs ago, whether it would be not a waste for them to take a second dose?

[HopIFjordeN]

Well, swim doesn't think it's that much af a waste, your pet will defenently get an effect - but the tricky part is to stop redoseing, all of a sudden your pet is far out there, not that that's a bad thing=) But if your pet haven't got that much experience, it could be too much...

[Songcycle67]

People argue on how long it takes for tolerance in the 5-HT receptors to kick in and block the action of any more LSD that would be administered, but most agree that it's within a 1-2 hour timeframe.

Beyond that point, by most accounts, the user may consume up to 500ug or more and get little more than a hash high.

[Shampoo]

Yes, receptor downregulation from LSD administration occurs within the first couple of hours of exposure. This means that many of the receptors which were present during the first administration have since receded into the cell membrane, removing themselves as potential targets for further 5-HT agonists. Further dosing will likely show a diminished return.

[Samadhi]

swim says the best thing to do is to ride out the experience one is already on... if one wishes to do more, wait a few weeks (for tolerance's sake) and drop the desired amount the next trial under safe set and setting.

[HopIFjordeN]

Originally Posted by songcycle67

People argue on how long it takes for tolerance in the 5-HT receptors to kick in and block the action of any more LSD that would be administered, but most agree that it's within a 1-2 hour timeframe.

Beyond that point, by most accounts, the user may consume up to 500ug or more and get little more than a hash high.

Swin would disagree with the 1-2hour timeframe, swim have often redosed with a clear effect, not to be mistaken for a placebo - the effect is not as strong, as if your pet dropped it all at once - but the next day, forget about it... only swim's personal experiences...