Effects - Wondering why coke/crack gets some people high, and others not a thing

[tweakette]

When swim has done coke, she has snorted it and IVed it. Never feel any high, there is the little tiny rush for the second you snort. Barely noticable, and swim gets drowsy as hell.

Smoking crack is the same way. Tiny initial feeling while actually still smoking it. Once it stops smoking up, nothing. Then just drowsiness, even if swim wasn't tired before the hit.

Most of swims friends tried doing coke too, and nothing. At most, they got a 2 minute slight buzz feeling but thats it.

How is it people can get addicted to that? Or overdose??! lol.

[General Grievous]

swim is into coke. and has a few theories..first he thinks its bad quality coke, and agrees with the crack assesment..hes done crach like 5 times and has noticed the same rush only when hitting it..its like swiy has to smoke to feel the rush its wack..but swim knows good coke from bad and likes coke because its worth it when its Good. the shit that gives swimy a two minute rush is usually cut with some shit..the good shit though swiy will take a .1g line and if its good shit...after a minute it will start coming on..time shifts and at 2-5 minutes swiy should feel the rush come and for swim is most intense at this time...the rush for swim usually lasts for 10 minutes after hitting..then it plateus for about another 10 and wears off.

ps swim should add he mixes drugs always to get max effects..with coke he mixes alcohol and bits of weed..the weed seems to acclerate the drugs and the coca ethylene is a must...swim NEVER does coke without alcohol.. its a must..best tip swim could give is drink 2-3 shots 20 minutes before hitting the yay...and keep a balance...swim likes the coke to always be over the liquor..but swim knows others who like to be trashed and more drunk then wired..to each his own

[tweakette]

Swim did good amounts of coke, and all different strains from totally different people. Swim did some recently because swim had given up but decided to try it again after a year or so. The people swim were with said it was good, they were into coke, and they wouldn't stop talking for like 30 minutes straight after they would do it!! Swim just felt shitty, and made swim just jones for meth.

Swim tried snorted about a gram in one line, it felt like All that happened was swim got real sweaty and felt like an intense meth come down feeling.


Swims main friends all shoot up meth, and find that coke does nothing.

Swim thinks maybe if you did meth for so many years, coke isn't going to really affect you.

[90%.]

Originally Posted by tweakette

Swim did good amounts of coke, and all different strains from totally different people. Swim did some recently because swim had given up but decided to try it again after a year or so. The people swim were with said it was good, they were into coke, and they wouldn't stop talking for like 30 minutes straight after they would do it!! Swim just felt shitty, and made swim just jones for meth.

Swim tried snorted about a gram in one line, it felt like All that happened was swim got real sweaty and felt like an intense meth come down feeling.


Swims main friends all shoot up meth, and find that coke does nothing.

Swim thinks maybe if you did meth for so many years, coke isn't going to really affect you.

different strains? yea going from meth to coke is a big difference...swiy will just be waiting thinking its like meth but its not

[ihavequestions]

meth is said to be 3 times more powerful than cocaine. so yeah that would make sense.

but some people have reported that cocaine doesnt do much for them. but then again there expectation may be high because its a hard drug and there expecting something mindblowing. but cocaine seems to be a relavtivly subtle drug in terms of the high. much like nocotine. some people try it and they wonder how the hell so many are addicted to it. but millions of them are.

keep in mind too that people who have adhd/add respond differently to stimulants often times not realy effecting them.

[Cryptic Concoction]

There is great variability in substances purveyed as cocaine on the illicit market. While neurological and neurochemical variations can account (in part) for variations in effects experienced, differences in potency and cocaine concentration will obviously account for differences in effects between people.

It is possible that if SWIY uses methamphetamine rather frequently that her use has resulted in reduced synthesis of dopamine. Consequently, inhibiting the reuptake of dopamine (cocaine's primary mechanism of action, along with inhibiting norepinephrine and serotonin reuptake) would precipitate less of an increase in the availability of dopamine compared to a user who has not used dopaminergic drugs.

Presumably, methamphetamine reverses the action of dopamine reuptake transporters, causing them to extrude dopamine into the synapse. This release upsets the brain's equilibrium, causing it to employ compensatory mechanisms (such as reducing the production of dopamine).

Thus, with already reduced levels of dopamine in the synaptic cleft (by virtue of frequent methamphetamine use), cocaine's blockage of dopamine reuptake transporters would result in less of an increase in dopaminergic activity. If we assume that the primary effects of cocaine are mediated by its action on dopamine reuptake transporters, obviously decreasing the availability of dopamine would attenuate its effects.

If SWIY uses methamphetamine frequently, I would say that it is highly likely that this use may be partially responsible for reduced effects cocaine delivers to her.

Reputation Comments on this post:

precision much appreciated

[General Grievous]

yeah swim hasnt tried meth/ice yet but wants to cuz he heard it was much better than coke trip with less comedown which swim thinks sounds NICE..its like going from a stronger drug to a weaker swiy will always compare it to other drugs..