Opinions - SWIM prefered Codeine wayy over Roxies???

[Boca Bitch]

SWIM tried both codeine (ranging in dose from 60-100mg.) and roxicodone (60mg.) on separate occasions. Every experience with codeine, which was taken orally in liquid form, left SWIM feeling amazing, but the one experience with Roxis, left him feeling sluggish, stupid, and uncomfortable.

I was wondering how his experiences could be so varied, considering the substances are so closely related.

[silentsonnet]

swim's pet piranha also prefers codeine to the other opioids. it's not really a big surprise: study biochemistry and you'll realize the tremendous number of diseases that occur with even the slightest mutation in our dna. likewise, all drugs vary even if only by one molecule. one's body chemistry will thus respond differently and have different personal preferences as well as reactions to drugs.

[Boca Bitch]

I guess this makes sense. SWIM would not have been surprised by merely "preferring" one over the other, it was just the completely different experience that shocked him.

He started with hard stimulants before ever trying a depressant: amphetamines and then cocaine, which both resulted in different, but equally enjoyable experiences. But I guess what you've mentioned would explain what happened with SWIM.

[gmeziscool2354]

swims roomate prioritized his downers like this (from good to bad)
Oxycodone, alcohol, tramadol, codiene, hydrocodone, pod tea, soma

so obviously most people don't necessarily place tramadol so high, and definitly not above soma and hydrocodone

just goes to show everyone is different

[Gradient]

Swim is confused. Codeine is codeine. Roxicodone is merely a brand-name of oxycodone, which has been characterized by a 5mg equivalence to 30 mg of codeine. I'm pretty sure both are converted to morphine in the brain, and the only difference is lipid solubility (ability to cross the BBB). Therefore, genetic polymorphisms shouldn't play a major role here.

Might your preference be subjective - set and setting perhaps?

[Boca Bitch]

Originally Posted by Gradient

Swim is confused. Codeine is codeine. Roxicodone is merely a brand-name of oxycodone, which has been characterized by a 5mg equivalence to 30 mg of codeine. I'm pretty sure both are converted to morphine in the brain, and the only difference is lipid solubility (ability to cross the BBB). Therefore, genetic polymorphisms shouldn't play a major role here.

Might your preference be subjective - set and setting perhaps?

That's what's been bugging me!!

Setting where SWIM took both codeine and Roxicodone were exactly the same. However, maybe it was method of ingestion that produced a different experience? Codeine taken orally, while the roxis where crushed and railed.

Considering orally consumed drugs take longer to reach the brain, maybe it produced a high that had a more gradual onset, vs. the railed roxis which hit the brain within seconds. This is just a guess, but it's the only possible reason I could imagine.

[Gradient]

Hmm, still a little strange. If memory serves, all of the semi-synthetic opiates are alkaline, as is codeine. Since the stomach pH ranges from 1-3, and nasal pH is generally between 5.5-7, one would expect far more of the codeine/oxycodone to be ionized in the stomach than in the nasal mucosa.

I'm no biochem wizz, but perhaps the chemical differences between codeine and oxycodone contribute to counter-intuitive ionizations since they're derived from different opiate alkaloids - perhaps there is a significant difference between codeine and all of the compounds synthesized from thebaine in terms of their pKa's. Along the same line of reasoning - maybe codeine binds to a wider array of receptors than oxycodone due to differences in molecular structures, and therefore genetic polymorphisms DO contribute through differences in individual receptor expression.

Interesting question...