USA Analog Act

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Federal Analog Act of 1986

Appendix A

Controlled Substance Analogue Enforcement Act of 1986

P.L. 99-570. Subtitle E, Title I.

SEC. 1202. TREATMENT OF CONTROLLED SUBSTANCE ANALOGUES

Part B of the Controlled Substances Act is amended by adding at the end of the following new section:

"TREATMENT OF CONTROLLED SUBSTANCE ANALOGUES"

"SEC 203. A controlled substance analogue shall, to the extent intended for human consumption, be treated, for the purposes of this title Title I; "[Enforcement"] and title III ("Interdiction") as a controlled substance in schedule I."

SEC 1203. DEFINITION.

Section 102 of the Controlled Substances Act (21 U.S.C. 802) is amended by adding at the end thereof the following: "(32)(A) Except as provided in subparagraph (B), the term `controlled substance analogue' means a substance ---

"(i) the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II;
"(ii) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulent, sic depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II;
"(iii) with respect to a particular person, which such person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II.

"(B) Such term does not include ---

"(i) a controlled substance;
"(ii) any substance for which there is an approved new drug application;
"(iii) with respect to a particular person any substance, if an exemption is in effect for investigational use, for that person, under section 505 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 355) to the extent conduct with respect to such substance is pursuant to such exemption; or
"(iv) any substance to the extent not intended for human consumption before such an exemption takes effect with respect to that substance.".

SEC. 1204. CLERICAL AMENDMENT.

The table of contents of the Comprehensive Drug Abuse Prevention and Control Sct of 1970 is amended by inserting after the item relating to section 202 the following new item: "Sec. 203. Treatment of controlled substance analogues.".

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Docket Management Branch (HFA-305)
Food and Drug Administration
12420 Parklawn Drive
Room 1–23
Rockville, Maryland 20857

Dear Sir:
This is in reference to Docket No. 98N-0148 regarding the inclusion of isomers, esters, ethers and analogues of all substances in Schedules I and II of the 1971 Convention. The Drug Enforcement Administration (DEA) has reviewed the available data regarding the above substances. These data could be incorporated into the critical reviews to be used or the 31st World Health Organization (WHO) Expert Committee on Drug Dependence.
Enclosed is DEA’s response to the questionnaire submitted to Member States by the Secretary-General of the United Nations pertaining to all substances in Schedules I and II of the 1971 Convention. The DEA is pleased to be providing such data to the Food and Drug Administration for inclusion in the U.S. submission to WHO for its critical review and prereview documents.
Sincerely,
Sapienza, Chief
Enclosures.
Questionnaire for data collection for use by WHO& CND of the Economic and Social Council of the United Nations
1. Is there any licit manufacture of
a) isomers, esters, ethers, and salts thereof of any of the substances in Schedules I and II of the 1971 Convention.
Isomers For the purposes of this questionnaire that the term “isomers” will mean enantiomers and diastereomers of psychotropic substances which are not included in Schedules I and II of the 1971 Convention. There are six substances for which this holds true:
(+)-cathinone
(-)-lysergic aciddiethylamide (LSD)
(+)-isolysergic acid diethylamide (2 substances)
(+)-tnvzs-4-methylaminorex (2 substances)
For the purposes of this questionnaire, manufacture is defined according to the 1971 Convention as “all processes by which psychotropic substances maybe obtained”. In the US, (+)-cathinone, (-)-lysergic acid diethylamide, (+)-isolysergic acid diethylamide (geometric isomer of LSD), and cis-4 methylaminorex are Schedule I controlled substances. trmzs-4-Methylaminorex is not controlled under the CSA.In the United States, cathinone, LSD, and (*)-trcms-4-methylaminorex are licitly manufactured for research and reference standards. The manufacturers do not stipulate whether or not specific isomers of the above substances are produced. Both isomers of cathinone are available in the US for use as analytical reference materials. Isolysergic acid is also available for the same purpose.
Esters and Ethers
For the purposes of this questionnaire, the licit manufacture of esters and ethers of the following substances was investigated: DMHP; parahexyl; THC; the six isomers of THC listed in Schedule I; psilocin; zipeprol. The DEA has no information pertaining to the licit manufacture of esters of the above substances. Small quantities of methyl ethers and related analogues of A8-, A9- and A9,11-tetrahydrocannabinol were manufactured for pharmacological evaluation.. Ether analogues have been manufactured for evaluation for their agonist and antagonist pharmacological properties in animal models.
b) a substance resulting from the modification of the chemical structure of substances already in Schedule I or II of the 1971 Convention?
For the purposes of this questionnaire, the term “analogues” will be utilized in place of the following phrase: “substances resulting from the modification of the chemical structure of substances already in Schedule I or II of the 1971 Convention”. The definition of analogues will be similar to one utilized in the Controlled Substances Act (CSA) for the purposes of this questionnaire and will imply: a chemical structure similar to that of a controlled substance in Schedule I or 11which produces a stimulant, depressant or hallucinogenic effect substantially similar to or greater than that produced by a Schedule I or 11controlled substance. The definition of amphetamine-like analogues would extend to substances such as ephedrine, pseudoephedrine, epinephrine, fenfluramine, dopamine... etc... that are utilized as licit pharmaceuticals, research substances and reference standards. These substances have an extensive legitimate market in the US. Using the above definitions, there would be hundreds of analogues of Schedule I and II psychotropic substances (See Shulgin, 1995). Many of these have been manufactured in small quantities in the United States for scientific and research activities. The following are some examples:
DEA has information pertaining to the licit manufacture of analogues and isomers of THC, from information submitted to DEA as part of research protocols and from information published in the scientific literature. Six bromination products of the isomeric dimethoxyphenethylamines (hence, isomers of Nexus) were manufactured for analytical purposes in 1997. For similar purposes, analogues of methoxy-MDA were synthesized from nutmeg oil and 3-methoxy-4,5-methylene-dioxybenzaldehyde (Clark et al, 1995). A series of N-substituted 3,4-methylenedioxyphenyl-2-butanamines were synthesized for analytical and research purposes (Clark et al, 1995). Metabolizes and analogues of THC were prepared for research purposes (chemical synthesis, pharmacological evaluation) in the United States. The methyl ether of bufotenine and hence a psilocin analogue was prepared for pharmacological evaluation and binding studies (Whitaker and Seeman, 1978). 2p-Bromo and p-methoxy analogues of methylphenidate were manufactured (Thai et al,1998) in the first reported asymmetric synthesis of methylphenidate and related substances. Analogues of A8-tetrahydrocannabinols with conformationally more-defined sidechains were manufactured (Papahatjis et al, 1998). Benzofiran, indan and tetralin analogues of MDMA were synthesized and analyzed for pharmacologicalactivity (Monte et al, 1993). 2. Has any abuse been reported ofi a) such isomers, esters, ethers or salts?
Isomers
The DEA has not received any reports of abuse of (-)-lysergic acid ethylamide, (+)-isolysergic acid diethylamide, or (+)-trmzs-4-methylaminorex.
Esters or Ethers
DEA has had no reports of abuse of esters or ethers of psychotropic substances. None of the substances that are listed in the DEA System To Retrieve Information from Drug Evidence (STRIDE) database are esters or ethers of psychotropic substances. It is unlikely that ethers of the tetrahydrocannabinol isomers will present a significant abuse problem. Research reports indicate that certain ether analogues of the cannabinoid drug class have minimal in vivo activity. The reports indicate that the phenolic hydroxyl is important for receptor recognition and in vivo potency (Compton et al, 1991).Another report indicates the molecular conformation of the methyl ether of A9-THC is unlike that of A9-THC and has great impact on its biological activity (Reggio, 1987). b) a substance resulting from the modification of the chemical structure (analogues) of substances already in Schedule I or II of the 1971 Convention?
For reasons of abuse and trafficking, the United States has controlled the following substances which can be defined as analogues of psychotropic substances: l MBDB, a positional isomer of N-Ethyl MDA. Additionally, all other positional isomers of hallucinogenic substances in Schedule I of the CSA l 4-bromo-2,5-dimethoxyphenethylamine l 5-methoxy-3 ,4-methylenedioxyamphetamine l bufotenine l 1-[(1 -thienyl)cyclohexyl]pyrrolidine & other PCP analogues l N,N-dimethylamphetamine 3
3. What isthedegree ofseriousness of thepublic health andsocialproblems associated with such abuse? Examples of public health and social problems are acute intoxication, accidents, work absenteeism, mortality, behaviour problems, criminality, etc. By virtue of the pharmacological similarity to parent compounds, abuse of many of the above substances can be expected to result in public health and social problems such as acute intoxication, accidents, work absenteeism, mortality, behaviour problems, and criminality. The risk to the public health has been evaluated for substances such as N,N-dimethylamphetamine, 2C-B, and PCP analogues and is contained in the control documents which are available from the Drug Enforcement Administration upon request. 4. Have there been seizures of any such substances in the illicit traffic during the previous three years? If so, what quantities were involved?
Isomers
(+)-cathinone
(-)-lysergic acid diethylamide (LSD)
(+)-isolysergic acid diethylamide (2 substances)
(+)-trans-4-methylaminorex (2 substances)
For the time period, 1/1/95 to 12/31/97 seizures for the following substances were reported in the DEA System To Retrieve Information from Drug evidence. Substance Name Number of Seizures cathinonea 9 I-lysergide 10 I l-isolysergide 10
4-methylaminorex 10
‘isomersofcathinonenotdistinguished
Esters and Ethers
DEA does not have any information to demonstrate seizures of esters and ethers of psychotropic substances.
Analo~ues
4 The following information was reported in issues of Microgram, 1995-1997. 1. In 1997, An exhibit containing 0.1 g of white granular material was seized by the North Carolina Bureau of Investigation in Raleigh, North Carolina. The exhibit contained 5-methoxy-N,N-dimethyltryptamine (an isomer of an ether of psilocin). 2. In 1997, the Forensic Science Service metropolitan Laboratory in London, England reported the analysis of a number of tablets that contained 4-methylthioamphetamine and caffeine. The tablets were mottled white, 14.0 mm in diameter, 4.7 mm thick and weighing 710 mg, single scored but with no other markings. 3. In 1995 and 1996, several seizures of tablets containing MDEA (3,4-Methylenedioxyethylamphetamine), MBDB (N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine) andMDMMA (N,N-dimethyl-3,4-methylenedioxyamphetamine) that originated from Holland were noted in Italy. The tablets had different markings: 1) pink tablets with a Fido-Dido” figure containing MDEA and MBDB; 2) white tablets with a” $“ figure containing MBDB; 3) beige tablets with a “bird” figure containing MDMMA. 4. In October 1996, the Florida Department of Law Enforcement, Orlando Regional Crime Laboratory seized two round white tablets with skull and crossbones on one side and “Killers” imprinted on the other side. The tablets contained round pink tablet with no markings that contained MBDB @-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine). 5. In July 1996, the New Jersey State Police, East Regional Laboratory, in Sea Gh_treported receiving several white colored tablets bearing a “$” logo. The tablets contained MBDB (Nmethyl-l-(3,4 -methylenedioxy phenyl)-2-butanamine) on the basis of chemical analysis. 6. In June 1996, the SouthwesternInstitute of Forensic Sciences in Dallas reported an exhibit of 19white colored tablets bearing a “$” imprint. Each tablet measured 10 mm in diameter and had an average weight of 300 mg. The tablets contained MBDB (N-methyl-l-(3,4-methylenedioxyph enyl)-2-butanamine) on the basis of chemical analysis. 7, In June 1996, the Utah Department of Public Safety Criminalistics Laboratory, Salt Lake City, recently encountered an exhibit consisting of 180 mg of off-white solid. Chemical analysis revealed methamphetamine, amphetamine and N,N-dimethylamphetamine, possible Ephedrabased methamphetamine. 8. In April 1996, the New Mexico Department of Public Safety Southern Crime Laboratory, Mesilla Park reported an exhibit consisting of an 87 mg lump of white material. Chemical analysis revealed methamphetamine, amphetamine and N,N-dimethylamphetamine, an indication that the exhibit was synthesized from Ephedra rather than ephedrine or pseudoephedrine. 9. In February 1996, The Metropolitan Police Forensic Science Laboratory, London, U.K.5 reported a 1.5 kg exhibit of inhomogeneous orange powder which was identified as l-(4-methylphenyl)ethy lamine by chemical analysis. 10. In October 1996, the Iowa Division of Criminal Investigation Criminalistics laboratory, DesMoines identified MBDB (N-methy1-l-(3,4-Methylenedioxypheny1)-2-butanamine) tablets (several). The tablets were round, white and bore a “$” imprint. 11. In April 1996, the Israel National Police Division of Identification and Forensic Science in Jerusalem reported ten seizures totalling 150 tan, unscored tablets with “$” imprint that contained MBDB (N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine) by laboratory analysis. 12.In January 1995, the North Carolina Bureau of Investigation in Raleigh reported the seizure of two exhibits of bufotenine (0.2g and 0.5g, respectively). 13. In April 1995, the Florida Department of Law Enforcement Regional Crime Laboratory in Ft. Meyers reported the seizure of 44 grayish-white single scored tablets bearing an image of the cartoon character “Fido-Dido”. The tablets contained MBDB (N-methyl-1-(3,4-methylenedioxyphenyl) -2-butanamine) by laboratory analysis. 14. In July 1995, the Ministerio De Sanidad Y Consumo Laboratory in Barcelona, Spain reported several submissions of white, single scored tablets bearing the “Fido-Dido” cartoon character imprint. The tablets contained MBDB (N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine). In another submission the laboratory received white, single cored tablets without the cartoon character impression that also contained MBDB. 15. In September 1995, the Israel National Police Division of Identification and Forensic Science reported a seizure of61 off-white “Fido Dido” tablets which contained MBDB (N-methyl-l- (3,4-methylenedioxyphenyl)-2-butanamine).16. In September 1995, the Health Department of Spain, Laboratory of Drugs in the Balearic Islands reported an exhibit received in 1994 consisting of 10 grayish white tablets bearing the“Fido Dido” character and which contained MBDB (N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine). 17. In November 1995, the Carabinieri Investigazioni Scientifiche Sottocentro laboratoria di Chimica in Parma, Italy reported several exhibits consisting of white single scored tablets with the “Fido Dido” cartoon character imprint and which contained MBDB (N-methyl-l-(3,4-methylene-dioxy phenyl)-2-butanamine). Some of the tablets also contained caffeine. 18. In November 1995, the Florida Department of Law Enforcement’s Regional Crime Laboratory in Tallahassee reported an encounter of 14 tan colored unscored tablets imprinted with “$“ and containing MBDB (N-methyl- l-(3,4 -methylenedioxy pheny1)-2-butan amine).6 19. In December 1995, the Ministerio de Sanidad Y Consumo, Laboratory de Drogas in Barcelona, Spain reported an exhibit of unscored tablets with “$” imprinted on one side which contained MBDB (N-methy1-l-(3,4-methylenedioxyphenyl)-2-butanamine). 20. In March 1998, the Virginia Division of Forensic Science in Norfolk reported exhibits consisting of white tablets with “Scrooge McDuck” logo containing MBDB (N-methyl-l-(3,4- methylenedioxyphenyl)-2-butanamine) and unmarked dark green tablets containing MDM~MDEA and Nexus (4-bromo-2,5-dimethoxyphenethylamine). They also report three submissions of white tablets with a “Fido Dido” logo containing MBDB (N-methyl-l-(3,4-methylenedioxyphenyl)-2-butanamine).21. In March 1998, the Virginia Division of Forensic Science in Roanoke reported two exhibits consisting of dark red tablets containing MBDB (N-methyl- l-(3,4-methylenedioxyphenyl)-2-butanamine) and caffeine. The following information was obtained from the DEA STRTDEdatabase for the time period 01/01/95 to 12/31/97
I Substance seized I Number of Seizures I
Bufotenine 2
Chloroephedrine 2 i
I d-Lysergic acid amylamide
I d-Lysergic acid butylamide
I d-Lysergic acid diisopropyl amide
I d-2-Bromolysergide 10
Dimethamphetamine 1
Dipropyltryptamine o
Fenfluramine 74
l-Methylpsilocybin o
IMescaline I
N-Butyl- 1-phenylcyclohexylamine
N-isobutyl- 1-phenylcyclohexylamine o
1-Phenylcyclohexylmorpholine o I
7
3,4-Dimethoxyamphetamine o
MBDB o
I 2C-B
I Tryptamine 10 I
8
5. Were such seized substances identified as being of local or foreign manufacture? Did they have any commercial markings?
See question #4, seizures reported in Microgram.
6. Was there any detection of clandestine laboratories manufacturing such substances?
In 1995-1996, most of the clandestine laboratories seized in the United States were producing methamphetamine. There were also a small number of methcathinone, amphetamine and phenyl-2-propanone laboratories seized. In past years, however, the Drug Enforcement Administration has identified the illicit manufacture of 2C-B, N,N-dimethylamphetamine and other amphetamine and tryptamine analogues,
Summary
The DEA has had relatively few encounters with isomers, esters, ethers and analogues of Psychotropic Substances. This is due, in part, to the passage of the Controlled Substances Analogue Enforcement Act of 1985(see attached document). This act amended the Controlled Substances Act to allow for the criminal prosecution of those persons who intentionally marketed or distributed a controlled substances analogue for the purposes of avoiding controlled substances laws. This provided the U.S. Drug Enforcement officials with a proactive response to the problem of designer-drug trafficking. The analogue provision of the Controlled Substances Act has proven to be a successfid instrument for attacking the problem of analogues and similar legislation that is in accord with individual legal systems could be considered by other countries. 9
References
Compton, D.R.; Prescott, W.R., Jr.; Martin, B.R.; Siegel, C.; Gordon, P.M.; Razdan, R.K.
“Synthesis and pharmacological evaluation of ether and related analogs of d8-, d9-, and d9, 11-
tetrahydrocannabinol. ” J. Med. Chem. 1991,34, 3310-3316.
Clark, R. C.; DeRuiter, J.; Noggle, F.T.; Valaer, A. “Identification of 1-(3,4-
methylenedioxyphenyl) -2-butanamines related to MDMA. ” Microgram, 1995, 28, 154-168.
Clark, C.R.; Noggle, F.T.; DeRuiter, J. “Analysis of methoxy MDA derivatives synthesized from
nutmeg oil and 3-methoxy-4,5-methylenedioxybenzaldehyde.” Microgram 1995, 28, 358-374.
Davies, D.J.; Garratt, P.J.; Tocher, D.A.; Vonhoff, S. “Mapping the melatonin receptor. 5.
Melatonin agonists and antagonists derived from tetrahydrocyclopent indoles,
tetrahydrocarbazoles and hexahydrocyclohept insoles.” J. Med. Chem. 1998, 41,451-467.
Monte, A.P.; Marona-Lewicka, D.; Cozzi, N.V.; Nichols, D.E. “Synthesis and pharmacological
evaluation of benzofiran, indan, and tetralin analogues of 3,4-(methylenedioxy) amphetamine.” J.
Med. Chem. 1993, 36, 3700-3706.
Papahatjis, D.P.; Kourouli, T.; Abadji, V.; Goutopoulos, A.; Makriyannis, A. “Pharmacophoreic
requirements for Cannabinoid side chains: multiple bond and CI’-substituted A8-
tetrahydrocannabinols. ” J. Med. Chem. 1998, 41, 1195-1200.
Reggio, P.H.; “Molecular determinants for cannabinoid activity: refinement of a molecular
reactivity template. ” NIDA Res. Monogr. 1987, 79, 82-95.
Shulgin, A.; Shulgin, A; “PIHKAL A chemical love story” Transform Press, Berkeley, CA 1995,
978 pp.
Thai, D.L.; Sapko, M.T.; Reiter, C.T.; Bierer, D.E.; Perel, J.M. “Asymmetric synthesis and
pharmacology of methylphenidate and its para-substituted derivatives. ” J. Med Chem. 1998, 41,
591-601.
Whitaker, P.M; Seeman, P. “High affinity 3H-serotonin binding to caudate: inhibition by
hallucinogens and serotoninergic drugs. ” Psychopharmacology 1978,49, 1-5.Edited by: Alfa

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CONTROLLED SUBSTANCE ANALOGUES
Frank L. Sapienza
Drug Enforcement Administration
November 1996
~ntroduction
During the 1980s the United States experienced a proliferation of the trafllcking and abuse
of illicitly produced substances, known as “designer drugs” or controlled substance analogues.
Controlled substance analogues refer to substances of abuse that produce the “high” or euphoria
of controlled substances (narcotics, stimulants, depressants and hallucinogens) but which have
chemical structures slightly different from those of controlled substances. Because each individual
substance was not specifically listed under the United States Controlled Substances Act (CSA),
they were not subject to the provisions of this law at that time. Similarly, these types of
substances were not controlled under international treaties unless specifically listed. Many of
these substances were phenethyhunine stimulants or ring-substituted amphetamine derivatives.
Controlled substance analogues are generally produced in clandestine laboratories by
altering the synthesis of controlled substances. Either the immediate precursor or a reagent is
altered to obtain the desired end-product. For example, the reaction of ephedrine with hydnodic
acid and red phosphorus yields methamphetamine, while the reaction of phenylpropanolarnine
(PPA) with these same reagents yields amphetamine. Thus, the production of these analogues
also may have an impact on chemical control programs since it is impossible to specifically list all
precursors or reactants. By selling these analogues, trailickers avoided the penalties that would
have been levied against those involved in the manufacture and distribution of controlled
substances. This phenomenon seems to have diminished in the United States in recent years, in
part, due to the enactment of legislation specifically targeting this activity. Available inilormation
indicates that Europe and other areas are currently experiencing a proliferation of analogues
produced in illicit laboratories. Following is a description of the analogue phenomeno~ as it
occurred in the United States, and the initiatives taken to counteract it,
The Controlled Sub~enomeno~
The concept of designing pharmacologically active, chemically related substances is
neither new nor restricted to illicit laboratories. In fact, most controlled substance analogues were
not designed by clandestine chemists, but are substances that were developed by legitimate
pharmaceutical chemists. Itiormation about these substances was generally published in the
scientific literature. In the quest for better medicinal agents, pharmaceutical companies synthesize
and test numerous analogues of a parent compound to find the one with the most and best
desiiable effects and the least side-effects. Many of these analogues mimic the qualitative actions
of the original compound, but may vary in potency, onset or duration of action. For example,
consider the large number of variations within the benzodiazepine family of drugs, in which the
parent drug is chlordiazepoxide (Librium). Many analogues of chlordiazepoxide (e.g., diazep~
alprazolam, flunitrazepam, etc.) are now legitimately marketed and have similar therapeutic and
psychoactive properties. There are an equally large number of phenethylamine analogues used
therapeutically as well as for abuse purposes.
The illicit synthesis of analogues for the purpose of avoiding controlled substance laws
also is not new. This phenomenon surfaced in the 1960s with the synthesis and distribution of
ring-substituted amphetamine analogues such as 3,4-methylenedioWamphetamine (MDA), 4-
methyl-2, 5-dimethoxyamphetarnine @OM/STP), 3,4,5 -trimethoxyamphetamine (TMA), paramethoxyamphetarnine
(PMA), 4-bromo-2,5-dimethoxyarnphetamine (DOB), and 2,5-
dimethoxyarnphetamine (DMA). Each of these hallucinogenic amphetamines was subsequently
controlled individually under the CSA and the Convention on Psychotropic Substances, 1971.
This clandestine laboratory activity in the United States was pivotal in the establishment of an
administrative scheduling provision in the U.S. CSA. In the 1970’s,amdogues of phencyclidine
(PCP) and methaqualone were controlled under the CSA after substantial quantities were illicitly
produced, distributed and abused.
The more recent problem with controlled substance analogues in the United States
occurred in the 1980s and centered around narcotic, stimulant and hallucinogenic analogues.
Analogues of narcotics included variations on fentanyl and pethidine (meperidine). Fentanyl is a
short-acting, highly potent substance used as an analgesic and anesthetic. Over ten fentanyl
analogues, known as China White and synthetic heroi~ with potencies of up to several thousand
times that of fentanyl, were synthesized in illicit laboratories, distributed and responsible for
scores of overdose deaths in the United States. Meperidine analogues included MPPP (1-methyl-
4-phenyl-4-propionoxypiperidine) and PEPAP [1-(2-phenethyl)-4-phenyl-4-acetoxypiperidine].
Samples of MPPP also contained a neurotoxic by-product, MPTP (1-methyl-4-phenyl- 1,2,5,6-
tetrahydropyridme) which is formed during the synthesis of MPPP. A number of individuals who
used the MPPP/MPTP mixture developed a severe Parkinson’s disease-like state as a
consequence. Neurological damage produced by MPTP is irreversible and worsens with time.
Modification of the phenethylamine and amphetamine molecule has produced the most
analogues identified in the illicit traf%c. These modifications can lead to substances with pure
central nervous system stimulant activity (e.g., methcathinone), hallucinogenic activity (e.g., 4-
bromo-2,5-dimethoxyphenethykun.ine (2C-B)) or a combination of both depending upon the dose
(e.g., 3,4-methylenedioxyamphetamine (MDA)). Changes to the phenyl ring may lead to
substances with hallucinogenic activity while changes to the ethylamine chain usually resuk in
varying levels of stimulant activity. The synthesis and activity of many of these analogues have
been reviewed by Glemon (See “Synthesis and Evaluation of Amphetamine Analogies”, in
estinely Produ~ D~es and Precursors, M. KleiL F. Sapie~ H. McCl~ Jr.
and I. Khm Editors, 1989). Additional data on many of these substances can be found in a
World Health Organization publication entitled ~er D~
.
Programme on Substance Abuse.
9
Several analogues of the hallucinogenic amphetamine, 3,4-methylenedioxyamphetarnine
(MDA) have been clandestinely manufactured and abused in the United States and around the
world. These include 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-Nethyhunphetamine
(MDE), 3,4-methy1enedioxy-N-hydroxyamphetamine, N-methyl-1-(3,4-
methylenedioxyphenyl)-2 -butanamine (MBDB). Each produces effects similar, at least, in part, to
MDA. Under the U.S. CS~ MBDB is controlled in Schedule I as a positional isomer of MDE.
Other ring-substituted amphetamines or phenethylamines, such as 2C-B (4-bromo-2,5-
dimethoxyphenethylamine) and PMMA (para-methoxymethamphetamine) have also been
identified in the illicit trtdlic. Scores of similar substances are described by Shulgin (See Shulgin
and Shulgin, in PIHKAL, A chemical Love Story, 1995)
Analogues of amphetamine and other central nervous system stimulants include N,Ndimethylamphetamine,
methcathinone (Ephedrine), arninorex and 4-methylaminorex. Each has
been produced in clandestine laboratories and identified in the illicit traflic in the United States
and elsewhere.
Until 1984, the United States had to rely on traditional administrative scheduling or
legislative control to add a substance to the list of controlled substances. Traditional
administrative scheduling under the U.S. CSA provides a role for both the law enforcement
(DEA) and health (Department of Health and Human Services; DHHS) authorities. It involves
the collection of all types of data by DEA a scientific and medical evaluation of that data by
DHHS and an independent evaluation by DEA. DEA must then make specific findings regarding
the abuse potential, accepted medical use and safety and physical and psychological dependence
potentials of the substance under review before determining its appropriate control status. The
process allows for comments horn interested parties and the opportunity for a hearing, if
requested. Under the best of circumstances, this process takes six months to one year. If a
hearing is requested it may take several years. The scheduling of MDm for example was
initiated in 1984 and finalized in 1988. This was not an effkctive response against the analogue
phenomenon.
In 1984, the U.S. Congress amended the CSA to include a provision for DEA to
temporarily place a substance into Schedule I for a period of one year if it was found necess~ to
do so to avoid an imminent hazard to the public safety. This control could be extended one time
for six months as long as procedures to permanently control the substance had been initiated.
This procedure can not be applied to substances already controlled in another schedule and to
marketed or investigational substances. DEA is not required to solicit or receive a scientific and
medical evaluation from the health authorities, only to provide a notification of its intent to
temporarily control the substance. DEA is required to consider the substance’s history and
current pattern of abuse, its scope, duration and significance of abuse, and its risk to the public
heait~ in making a determination of whether the substance should be subject to emergency
controls. Emergency scheduling imposes the fill range of regulatory controls and criminal
sanctions on the substance and those who handle it. DEA first used its emergency scheduling
authority in April 1986 and has placed 21 substances under emergency control since then. These
have included fentanyl and meperidine ana.logues, stimulant amphetamine analogues,
hallucinogenic amphetamine analogues and a tryptarnine analogue. These substances were placed
into Schedule I on an emergency basis because of their appearance in the illicit drug trafEic,
.
-.
chemical similarity to known controlled substances, and known or predicted pharmacological
similarity to controlled substances. When specific pharmacological data was not available,
structure activity relationships formed an important basis for initial control. Once sufficient
scientific data was obtained, permanent scheduling followed each of these emergency actions.
Although this emergency scheduling process greatly reduced the amount of time required
to place a “new” substante under the CSA, clandestine laboratory operators continued to
synthesize new analogues before the DEA could control them, even on an emergency basis. The
emergency controls continued to be reactive and took a few months to complete. The U.S.
government looked for away to become proactive. Two basic alternatives were considered. The
first was class scheduling. This would list chemical structural parameters for different classes of
substances subject to abuse and control. All substances which fell within these parameters would
be considered controlled. Defining these parameters was rather difficult for the many classes of
controlled substances. Additionally, this method would impose regulatory controls on thousands
of substances and could negatively impact legitimate drug development.
The second alternative was to impose only criminal sanctions on the activity of
manufacturing and distributing an analogue intended for human consumption. This was the
approach taken and in 1986, the CSA was again amended. The Controlled Substance Analogue
Enforcement Act of 1986 (See attached) provided that a controlled substance analogue, to the
extent intended for human consumptio~ could be treated as a Schedule I substance. It defined a
controlled substance analogue as a substance which(1) has a chemical structure substantially
similar to that of a controlled substance in Schedule I or II; (2) produces a stimulant, depressant
or hallucinogenic effect substantially similar to or greater than that produced by a Schedule I or II
controlled substance; or (3) is represented by an individual to produce such an etl%ct. Aga@
marketed substances, or those under active investigation%are exempt from this provision. Whh
this provisiow analogues of controlled substances are covered under the criminal, but not the
regulatory, provisions of the CSA. The requirement that analogues be intended for human
consumption and the exemptions for marketed and investigational substances ensure that
legitimate research and development are not hindered.
It is important to note that there is no list of controlled substance analogues. Whether a
substance is a controlled substance analogue is determined at each criminal proceeding. Once a
substance is permanently controlled under the CS~ there is little debate as to whether that
substance is classified as a controlled substance and subject to the criminal provisions of the CSA.
Individuals who are prosecuted for manufacture or distribution of a controlled substance analogue
can force the prosecution to prove on each occasion to a judge and/or a jury that a substance
meets the definition of a controlled substance analogue. Expert testimony maybe heard in each
criminal proceeding to determine if a substance meets the definition of a controlled substance
analogue. Forensic chemists are used to describe the points of similarity between the structure of
the analogue compared to that of a controlled substance. Biological dat% if available, or structure
activity relationships, are used to determine the pharmacological similarity between the controlled
substance and the analogue. If an analogue is identified in the ilhcit traflic on several occasions,
emergency controls are usually imposed and ultimately, the substance is permanently scheduled
under the CSA.
..-.
The U.S. government has successfully prosecuted a substantial number of individuals
under this provision for the manufacture and distribution of various anrdogues. These have
included analogues of MDA amphetamine, methamphetamine, meperidine, fentanyl and others.
It appears that most, if not all, of the substances described in “PIHKAL” could meet the definition
of controlled substance analogue, and if intended for human consumption, would fdl under the
analogue provision of the CSA. Individuals manufacturing and distributing these substances can
and have been successfully prosecuted. Both the emergency scheduling and the analogue
provisions of the CSA have withstood challenges in the courts.
An examination of the scheduling actions under the CSA since 1980 show that there were
a large number of illicit substances (each could be considered an analogue) controlled and
emergency scheduled in the 1980s (See attached). This activity has dramatically decreased since
199o with only four substances placed under emergency control. Additionally there are currently
no controlled substance analogues under review in the United States for emergency or permanent
control. This decrease in the production and distribution of analogues can be attributed, at least
in part, to the passage of the emergency and analogue provisions of the CS~ successful
prosecutions under these provisions, and unsuccessful challenges to these statutes in the courts.
Both of these statutes, but particularly the analogue statute, have proven to be successful and
effective tools in attacking the problem of controlled substance analogues, Similar legislatio~
consistent with individual legal systems, should be considered by other countries.

[Politicalchalk]

SWIM has a few questions about this post. Thanks for posting it...a bit/dry, but all good information to know about.

"(1) has a chemical structure substantially
similar to that of a controlled substance in Schedule I or II;
(2) produces a stimulant, depressant, or hallucinogenic effect substantially similar to or greater than that produced by a Schedule I or II controlled substance; or
(3) is represented by an individual to produce such an effect."

The above, as SWIM understands it, used in the courts as the criteria for prosecution. The second contention says "an effect... similar to or greater than..." So if SWIM made some random chemical that vaguely (not substantially) resembled a chemical in schedules I or II, but whose effect was actually LESS potent yet still active, would that lesser chemical not be subject to this analogue act?

Secondly, the last provision says essentially "If you get caught selling oregano as marijuana, they can charge you with selling marijuana." Is this correct? SWIM once heard a tale about someone who would empty Benadryl (diphenhydramine hcl) capsules into a bag. He sold this white-powder-in-a-bag (which he called "Hallucidine") as a new drug, prepared by him by hand, and that produced hallucinogenic effects. This is a known side effect of excessive amounts of diphenhydramine. He would sell for about 20 dollars a "trip," to be mixed in a glass of any juice you like. SWIM was told the actual dose was around 400mg, with the capsules being about 25mg a piece. Now, SWIM took latin all through high school -- sometimes his teacher could get a few extra bucks by helping pharmaceutical companies come up with brand names for soon-to-be-released medications. For instance, the latin word for hard is durum, and your skin is called your dermis. So a good name for a skin cream for hard, cracked skin could be Duraderm. Seeing that diphenhydramine is not controlled, and that guy never technically lied to anyone (just deceit), could he be prosecuted? This is assuming no one was allergic and no one was hurt as a result of it's use. DO NOT TRY THIS AT HOME! IT'S NOT A SAFE IDEA EVEN IF LEGAL, which SWIM is not sure of one way or the other.

Finally, what of the muscle relaxer Soma (carisoprodol)? It's a pro-drug which breaks down into meprombamate, a schedule IV sedative-hypnotic not used often these days. If SWIM recalls correctly, some states individually scheduled the drug into schedule IV. Other states require a prescription. In some countries it's sold OTC. In SWIM's state, it's Rx only...what would happen if one was caught with a few carisoprodol tablets in his pocket? Correct SWIM if wrong, but if that happened, wouldn't the police only be able to confiscate the pills, but not actually charge them with a crime, seeing it's not controlled in his state? SWIM also heard that recently carisoprodol was being considered being federally scheduled. Can anyone verify this, one way or another?

Thanks, sorry it's so long!

Reputation Comments on this post:

interesting questions, thanks