Drug info - Quazepam - any info on this one?

[tyranny4u]

SWIM would like to know a bit about about Quazepam (Doral).
As it is the only benzo SWIM knows so far which has a sulphuric atome
where the other benzos have the oxygene atome, there could be some changes in effect?
SWIM created a picture of the 2D molecules of Quazepam and Flurazepam to show what he means
SWIM chose Flurazepam, as it has the same halogenes bound as Quazepam has, Fluorine and Chloride. Both are strong hypnotics.



Are there some SWIY that could post experience with Doral / Quazepam?

tyranny4u added 1 Minutes and 5 Seconds later...

Sorry for double post, but image won't show in the thread ^^

[Jatelka]

There's very little here on Quazepam. In fact, only this...

http://www.drugs-forum.com/forum/sho...light=quazepam

id like to hear more about it (for purely informational purposes only, of course )

[RaverHippie]

Who'd have thought that researching a drug prescribed to treat insomnia is fun while having insomnia

Quazepam has a very long half-life so it's use for prescribed conditions can be effective in long term scenarios without developing tolerance and ending with withdrawal like short half life benzodiazepines. Usually the withdrawal will exacerbate the symptoms which required prescription in the beginning, which in effect, bringing renewed need for the short half life benzo or some other sleep aid. Quazepam is able to circumvent this process apparently.

Two articles support this phenomena the 1st compares hypnotic qualities before and after dosing and withdrawal cycles with triazolam.

"Two benzodiazepine hypnotics, triazolam, 0.25 mg, with a short elimination t1/2, and quazepam, 15 mg, with a long t1/2, were evaluated in 22-night sleep laboratory studies. Quazepam improved sleep significantly during both short- and intermediate-term use. Daytime sleepiness, which decreased with continued use, was the side effect most often associated with quazepam dosing. In contrast, triazolam dosing did not significantly improve any of the major sleep efficiency parameters, and there was a rapid development of tolerance for the drug's slight initial effectiveness. In addition, there were a number of behavioral side effects including amnesia, confusion, and disinhibition. Withdrawal of triazolam was associated with sleep and mood disturbances (rebound insomnia and rebound anxiety), whereas quazepam exerted carryover effectiveness. Thus the data in this study show that the 0.25 mg dose of triazolam, which is being prescribed increasingly, has a profile of side effects that is similar to that of the 0.5 mg dose."

http://www.ncbi.nlm.nih.gov/pubmed/3530586

I couldn't find a link to the full pdf of the study so I just cpoied the abstract and left the source link.

the second article simply focuses on quazepam, again emphasizing the lack of withdrawel and no interruption of benefits from taking the long acting benzodiazepine.

"Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia. It is slowly eliminated due to the long elimination half-lives of the parent compound and its two active metabolites, 2-oxoquazepam and N-desalkyl-2-oxoquazepam. This drug is recommended in doses of 15 mg for adults and 7.5 mg for geriatric patients. Sleep laboratory studies and clinical trials have shown that the 15 mg dose is quite efficacious for inducing and maintaining sleep not only with initial and short-term use but also with continued use. The 7.5 mg dose which has been studied less extensively has also been shown to be effective for inducing and maintaining sleep. There is considerable evidence of carryover effectiveness both during drug administration and after withdrawal. Thus, rebound phenomena are not observed during administration (early morning insomnia and daytime anxiety) and after withdrawal (rebound insomnia). Furthermore, certain behavioral side effects that have occurred with certain benzodiazepines (triazolam) have not been reported with quazepam. The only notable side effect seen with quazepam is a variable degree of daytime sedation, which can be minimized by intermittent use of the 15 mg dose when necessary and use of the 7.5 mg dose in the elderly. In comparison to triazolam and temazepam, quazepam is more effective with short-term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance. Most important, quazepam lacks the frequent and severe side effects increasingly reported with triazolam use or following its withdrawal."

http://www.ncbi.nlm.nih.gov/pubmed/1969151

again no full text anywhere so just the abstract is copied+pasted.

as mentioned in the thread Jatelka linked to, Quazepam is poentiated by grapefruit juice. and for specifics, quazepam is presystemically metabolized by CYP3A4 and CYP2C9 liver enzymes.

full text article comparing effect of grapefruit juice on quazepam and triazolam uploaded to DF file archive

Overall it seems like it's prescribed for its great benefits for providing insomnia relief, some sources say that it also impairs motor coordination and this effect can last for a while. Multiple sites warned of consuming alcohol anytime before, or even days after a single dose has been taken due to the long half life. This is where one would think careful experiments could prove to show how this one could be enjoyed by monkeys recreationally. Take a dose then the next day have a small drink maybe?

Reputation Comments on this post:

great research and post here

[tyranny4u]

SWIM thought of it more as a recreational substance. SWIM had Flurazepam
a few times (30 mg with low tolerance up to 150 mg with a higher tolerance)
Flurazepam also is a benzo with a pretty long half-life - the english wikipedia
site about Flurazepam sais "up to 250 hours".
SWIM always used Flurazepam as a hypnotic (very useful stuff to avoid the
crash after tweaking too long), but had no recreational use.
SWIM is just curious about if Quazepam has interesting side effects for any
other use than hypnotic.

[RaverHippie]

Originally Posted by tyranny4u

SWIM is just curious about if Quazepam has interesting side effects for any other use than hypnotic.

Unless "impairment of motor function" is considered of recreational potential, SWIM thinks this one is left in the category of "good only for its intended use"

SWIM had this idea that may have been missed in his wall-of-text post earlier "Multiple sites warned of consuming alcohol anytime before, or even days after a single dose has been taken due to the long half life. This is where one would think careful experiments could prove to show how this one could be enjoyed by monkeys recreationally. Take a dose then the next day have a small drink maybe?"