Effects - oral use question

[gmeziscool2354]

couldn't find much as far as this is concerned. Is cocaine orally active?

would putting some blow into OO gel caps and popping that be at all worth it?

my hampster was wondering. He thought that this may be valid due to a reaction with the yeah and the cut upon entering the highly acidic environment of the gut but has no personal or reliable anecdotal experience to base this on

any one have any ideas?

[chillinwill]

I found this little article

Titre du document / Document title
Contribution of the active metabolite, norcocaine, to cocaine's effects after intravenous and oral administration in rats : pharmacodynamics

Auteur(s) / Author(s)
WANG Q. (1) ; SIMPAO A. (1) ; SUN L. (1) ; FALK J. L. (1) ; LAU C. E. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Psychology, Rutgers, The State University of New Jersey, 152 Frelinghuysen Road, Piscataway, NJ 08854-8020, ETATS-UNIS
Résumé / Abstract

Rationale: Oral cocaine is more effective than IV cocaine by pharmacokinetic and pharmacodynamic analysis. One explanation is involvement of the active metabolite, norcocaine, in cocaine's effects. Objectives: To evaluate norcocaine's contribution to oral cocaine's effects, norcocaine's effects as a parent compound were determined and compared to those of cocaine using a differential reinforcement of low rate (DRL 45-s) schedule and spontaneous activity (large and small movements) after IV and PO routes of administration. Methods: The effects of cocaine and norcocaine on DRL performance (shorter-response and reinforcement rates) and spontaneous activity were investigated in 3-h sessions. The changes in effects across time (effect-time profiles) and dose-response curves (DRCs) were constructed to evaluate the duration of action and potency (ED50) of both drugs. Results: Under the DRL 45-s schedule, effect-time profiles showed both drugs via the two routes of administration significantly increasing and decreasing shorter-response rates and reinforcement rates, respectively. However, cocaine produced greater effects on shorter-response rates than norcocaine, while both drugs produced comparable effects on reinforcement rates. For spontaneous activity, although IV cocaine, PO cocaine, and PO norcocaine dose- and time-dependently increased spontaneous activity, cocaine's effects were more profound than those of norcocaine. Effect-time profiles revealed that the duration of drug action was a function of dose, route, and behavioral paradigm used. According to ED50 values, IV cocaine was more effective than PO cocaine; however, PO cocaine was more effective than IV cocaine as judged by ED50 values corrected for absolute oral bioavailability. Conclusions: Norcocaine's contribution to oral cocaine's effects on DRL performance is evident. Other mechanism(s), such as a greater acute tolerance to IV cocaine's effects than to PO cocaine's effects, can be excluded.

Revue / Journal Title
Psychopharmacologia ISSN 0033-3158 CODEN PSYPAG
Source / Source
2001, vol. 153, no3, pp. 341-352 (30 ref.)
Langue / Language
Anglais
Editeur / Publisher
Springer, Berlin, ALLEMAGNE (1959) (Revue)

http://cat.inist.fr/?aModele=afficheN&cpsidt=876752

[Benga]

please read up and eventually post in the threads filed under the "oral use" thread prefix.........................

http://www.drugs-forum.com/forum/for...c&daysprune=-1

thanks