Effects - Barbiturate potentiators?

[Herbal Healer 019]

Any1 know of any barbi potentiators, specifically butalbital?

Is butalbital metabolized by the cyp sumthin sumthin enzyme? if so SWIM is assuming grapefruit juice is a good potentiator, correct?

[PsychoActivist]

First off, I probably don't need to tell you this but Barbituates in general can be extremely dangerous on their own. By mixing them with anything to potentiate them or increase the effect one could really be putting themselves in even more danger. So please tell SWIY to keep this in mind and be very cautious.

In theory the grapefruit juice thing should work for Phenobarbital but that is the only Barb that SWIM has been able to see that is specifically metabolized by the cyp3a4 enzyme.
Apparently, Butalbital is Metabolized via cyp450 (The oxidase system in which the 3a4 enzyme exists) but SWIM has found nothing that says it is specifically metabolized via 3a4 and he believes that this is specific area in which the competition for metabolism between the constituent in GFJ and x=drug occurs. He is kind of confused about this now. He is kind of an amatuer at Pharmacokinetics so maybe someone with more knowledge can either second this or help set SWIM straight on this. If SWIY decides to try using GFJ with it let us know how it turns out for him.

[RaverHippie]

Easiest one is alcohol, but also a deadly potentiator as in the case of benzodiazepines.

[chillinwill]

Agree with the alcohol one being the easiest....Red Rock has combined butalbital many times when he was naive and younger and luckily he is still here to talk about it....The difference between a high and an OD on just barbituates alone is very slim but when combined with alcohol, it can become extremely deadly. Red Rock highly doesn't recommend combining with alcohol. Maybe some type of opiate would potentiate it but be careful with that as well

[fiveleggedrat]

Aren't the margins for "high" and "overdose" too close to really play with, especially with potentiators?

Be careful, OP.

Reputation Comments on this post:

I am glad you added this as this what I was trying to touch on in the beginning of my post

[RaverHippie]

There's a very good reason these were phased out. High addiction potential, High overdose potential.

Benzos are the way to go. If SWIY is still interested, definitely take it slow, keep consecutive sessions with barbs spread days apart to avoid tolerance/addiction, and if using alcohol, be even more careful with both ingredients to learn boundaries.

[Herbal Healer 019]

SWIM told me he has aquired some hydrocodone 7.5/500, suboxone, oxycontin, tramadol, poppy straw, kratom and adderall (prob not so good, unless 4 jitters).

Which one of those would potentiate the butalbital synergysically?

Swim has tried cannabis, butalbital & 100mg tram at once & found this greatly added to the downer effects, mainly sedation & lack of coordination even more so, & SWIM thought the cannabis overpowered both the tram & cannabis. With the afformentioned combo, slight slurring of words & less mental clarity (thinking slow) during social interaction was pronounced as apposed to butalbital alone, which was more anxiolitic; along the lines of valium

Dose of combo: 200mg butalbital/1600mg caffeine/1300mg acetaminophen, 100mg tramadol/ cannabis orally. butalbital doses were spread out to 100mg per 5 hrs.

[Seconal]

Alcohol is the absolute best barb potentiating substance - but beware, it's also a very deadly combination too. Many, many people have committed suicide and accidentaly died like that (remember Marilyn Monroe and Jimi Hendrix?). Why does your swim feel the need to potentate them anyway? These drugs are already very strong to begin. What ever swim does, hopefully he's careful.

Butalbital is actually considered to be a weak barb with no recreational value but still bad if mixed with alcohol.

[Herbal Healer 019]

I always thought Jimi Hendrix died of a heroin OD?

Yea SWIM has potentiated butalbital with alcohol & finds it adds an element of confusion & mental haziness which isn't present with butalbital alone.

SWIM thinks butalbital does have rec. value, but def. agrees it is weak which is why he feels the need to potentiate it. Butalbital is the only prescription barbiturate on the market in America other than for veterinary use, so SWIM decided to buy some & give it a try. The closest thing SWIM would compare butalbital to is valium with less euphoria & more of a bodily intoxication simular to alcohol.

[Seconal]

Originally Posted by Herbal Healer 019

I always thought Jimi Hendrix died of a heroin OD?

Yea SWIM has potentiated butalbital with alcohol & finds it adds an element of confusion & mental haziness which isn't present with butalbital alone.

SWIM thinks butalbital does have rec. value, but def. agrees it is weak which is why he feels the need to potentiate it. Butalbital is the only prescription barbiturate on the market in America other than for veterinary use, so SWIM decided to buy some & give it a try. The closest thing SWIM would compare butalbital to is valium with less euphoria & more of a bodily intoxication simular to alcohol.

No, Jimi Hendrix died in his sleep after taking 9 pills of a barbiturate combo drug called Vesperax (secobarbital/brallobarbital & hydroxyzine) with wine and literally choked to death on his own vomit. Normally if a person OD's on a toxic amount something the body tries to reject it, but since Hendrix was passed out from his meds and unable to wake-up - that's what happened to him.

Be careful swim.