Drug info - Etaqualone

[Mish]

SWIM has recently managed to get ahold of 1g of Etaqualone and was interested in finding out some general (and more detailed chemical and biological) information about it. SWIM was hoping that by way of some of the SWIY-chemists residing on this forum, deductions could be made from the structural similarities between this compound and it's "popularized" cousin, Methaqualone (Quaaludes/Mandrax)...

Methymethaqualone (MMQ) did nothing for SWIM orally at 250mg - and SWIM didn't want to go above that for fear of the low seizure threshold - and, when 20mg was smoke, produced a short but distinctively dissociated rush of mild euphoria. SWIM's overall impression was not great.

However, SWIM has just come across this analogue Etaqualone. This, it seems, is much more likely to have an effect as it is structurally a lot similar to the original Quaaludes. Below is a comparison of chemical formulas for the analogues that seem to be available:

• Methaqualone: 2-methyl-3-(2-methylphenyl)-4-(3H)-quinazolinone
• Etaqualone: 2-methyl-3-(2-ethylphenyl)-4-(3H)-quinazolinone
  
  as opposed to
  
  
• Methylmethaqualone: 2-methyl-3-o-tolyl-4(3H)-quinazolinone

SWIM is not particularly familiar with the chemistry of these structures, but is aware that the addition of the prefix 'Methyl-' in the MMQ analogue meant for supposedly faster absorbtion/onset; and that the 'o-tolyl-' addition also has the drawback of lowering the seizure threshold.

However, it seems that Methaqualone and Etaqualone are almost identical in structure, so it should thus follow that they should have near identical effects...? What differences occur to effects/bioavailablity when the -methyl group is substituted by an -ethyl group? (as in: '2-methylphenyl' for Quaaludes, and '2-ethylphenyl' for Etaqualone?

From SWIM's (admittedly very, very limited understanding), this would just mean a shorter duration of effects. Is this correct?

From 2 separate sources, SWIM has heard that:

Depending on the structure they are attached to, generally ethyl groups shield neighbouring groups and make them less available than methyl groups. The longer the carbon chain, the more reactive the atom gets so adding an extra carbon to make an ethyl group would increase it's reactions.

This seems to be somewhat contradictory to SWIM. If the ethyl group shields neighbouring groups then subsequently Etaqualone should become less bioavailable than Methaqualone. If someone could relay the above information into laymans' term SWIM would be much appreciative.

There are little to no reports out on the 'net regarding Etaqualone experiences; presumably because it has only been fairly recently synthesized or - more likely - brought into the public eye.

SWIM is interested in the pharmacokinetics of this compound as he knows how popular Rorer 714's (300mg Methqualone in a capsule) were because in the 1960's and 70's, and was wondering how such a seemingly minor change can really alter the drugs effects...

However, being in possession of a small amount of Etaqualone means that SWIM is also most interested in the dose. SWIM has heard from other sights and reports that a dose of about 250mg orally produces a hypnotic sedating euphoria that lies somewhere between Diazepam and GHB - would this be true?

SWIM is considering both oral ingestion [250-300mg], inhalation [100mg], and insufflation [200mg] but would like to know which is the best. Bearing in mind SWIM has a naturally high tolerance to most GABA A receptor agonists (14mg of Clonazepam to feel anything; 60mg Diazepam; 160mg Temazepam; 80mg Zolpidem/Ambien) and, to a lesser extent GABA B agonists, where would a good starting dose be orally?

If anyone has had any experience with 'ludes in any form then please post them, as DF seems to be lacking in subjective experience reports that actually go into details about the dosages and explicit effects.

Thanks

EDIT - Even though this is a thread is really looking for guidance and general 'Drug Info' on the compound, SWIM is aware that it may have been placed in the incorrect sub-forum of the board. If so, please feel free to move it.

Reputation Comments on this post:

good info