Drug info - Etaqualone

[Mish]

SWIM has recently managed to get ahold of 1g of Etaqualone and was interested in finding out some general (and more detailed chemical and biological) information about it. SWIM was hoping that by way of some of the SWIY-chemists residing on this forum, deductions could be made from the structural similarities between this compound and it's "popularized" cousin, Methaqualone (Quaaludes/Mandrax)...

Methymethaqualone (MMQ) did nothing for SWIM orally at 250mg - and SWIM didn't want to go above that for fear of the low seizure threshold - and, when 20mg was smoke, produced a short but distinctively dissociated rush of mild euphoria. SWIM's overall impression was not great.

However, SWIM has just come across this analogue Etaqualone. This, it seems, is much more likely to have an effect as it is structurally a lot similar to the original Quaaludes. Below is a comparison of chemical formulas for the analogues that seem to be available:

• Methaqualone: 2-methyl-3-(2-methylphenyl)-4-(3H)-quinazolinone
• Etaqualone: 2-methyl-3-(2-ethylphenyl)-4-(3H)-quinazolinone
  
  as opposed to
  
  
• Methylmethaqualone: 2-methyl-3-o-tolyl-4(3H)-quinazolinone

SWIM is not particularly familiar with the chemistry of these structures, but is aware that the addition of the prefix 'Methyl-' in the MMQ analogue meant for supposedly faster absorbtion/onset; and that the 'o-tolyl-' addition also has the drawback of lowering the seizure threshold.

However, it seems that Methaqualone and Etaqualone are almost identical in structure, so it should thus follow that they should have near identical effects...? What differences occur to effects/bioavailablity when the -methyl group is substituted by an -ethyl group? (as in: '2-methylphenyl' for Quaaludes, and '2-ethylphenyl' for Etaqualone?

From SWIM's (admittedly very, very limited understanding), this would just mean a shorter duration of effects. Is this correct?

From 2 separate sources, SWIM has heard that:

Depending on the structure they are attached to, generally ethyl groups shield neighbouring groups and make them less available than methyl groups. The longer the carbon chain, the more reactive the atom gets so adding an extra carbon to make an ethyl group would increase it's reactions.

This seems to be somewhat contradictory to SWIM. If the ethyl group shields neighbouring groups then subsequently Etaqualone should become less bioavailable than Methaqualone. If someone could relay the above information into laymans' term SWIM would be much appreciative.

There are little to no reports out on the 'net regarding Etaqualone experiences; presumably because it has only been fairly recently synthesized or - more likely - brought into the public eye.

SWIM is interested in the pharmacokinetics of this compound as he knows how popular Rorer 714's (300mg Methqualone in a capsule) were because in the 1960's and 70's, and was wondering how such a seemingly minor change can really alter the drugs effects...

However, being in possession of a small amount of Etaqualone means that SWIM is also most interested in the dose. SWIM has heard from other sights and reports that a dose of about 250mg orally produces a hypnotic sedating euphoria that lies somewhere between Diazepam and GHB - would this be true?

SWIM is considering both oral ingestion [250-300mg], inhalation [100mg], and insufflation [200mg] but would like to know which is the best. Bearing in mind SWIM has a naturally high tolerance to most GABA A receptor agonists (14mg of Clonazepam to feel anything; 60mg Diazepam; 160mg Temazepam; 80mg Zolpidem/Ambien) and, to a lesser extent GABA B agonists, where would a good starting dose be orally?

If anyone has had any experience with 'ludes in any form then please post them, as DF seems to be lacking in subjective experience reports that actually go into details about the dosages and explicit effects.

Thanks

EDIT - Even though this is a thread is really looking for guidance and general 'Drug Info' on the compound, SWIM is aware that it may have been placed in the incorrect sub-forum of the board. If so, please feel free to move it.

Reputation Comments on this post:

good info

[Synesthesiac]

Dont know if this should be here or in the research chems section. There appears to not be any decent report of Etaqualoneusage dosage and effects anywhere on the internet, but a popular online vendor has just got a lot of this in stock, so no doubt there will be a good few reviews about soon.

From the very few reports I've read, some say Etaqualone is very similar to its illegal analogue Methaqualone but has a much shorter duration, and some people claim no effects at all. But they may have got it from a dodgy vendor selling flour. You never know. And apparently it may not be very water soluble, so it may not be as effective nasally as orally, but this is based on only hearsay at this point.

Keep us posted if swiy does it. And with something this new and unknown its always a good idea to start very small. Even at 1-5mg to test for allergic reactions.

[Mish]

SWIM tried 200mg nasally last night (after 1mg to test for allergic reactions). No effects whatsoever.

SWIM will try 500-600mg orally tonight and see what happens. SWIM is aware of rapid tolerance developing so reckons this dosage would normally equate to 300-400mg orally (assuming no tolerance).

SWIM will report his findings later on; perhaps doing some form of live report as the 'net is severely lacking in subjective experiences...

[Synesthesiac]

Swiys experience seems exactly the same as some other guy I read elsewhere who did 200mg nasally and got nothing. There is another thread about this stuff in the RC section where I posted the only two brief experiences I found for Etaqualone; http://www.drugs-forum.com/forum/showthread.php?t=71586 They are both conflicting, one says nay, and one says yay, but they dont give any detailed information at all really.

What would be good is a way to test this stuff to see if it really is what people think they've got, but I dont have a clue how that could be done.

[Mish]

Originally Posted by Synesthesiac

Swiys experience seems exactly the same as some other guy I read elsewhere who did 200mg nasally and got nothing. There is another thread about this stuff in the RC section where I posted the only two brief experiences I found for Etaqualone; http://www.drugs-forum.com/forum/showthread.php?t=71586 They are both conflicting, one says nay, and one says yay, but they dont give any detailed information at all really.

What would be good is a way to test this stuff to see if it really is what people think they've got, but I dont have a clue how that could be done.

Hahah, the negative quote is SWIM under a different name Which site was that from? BL? CHL?

SWIM will be taking 600mg in 30 minutes.

[0utrider]

yeah would be nice if SWIY could post his experiences in that post.

[Herbal Healer 019]

For what ligitamate reason were quaaludes completely banned from pharmaceutical production? was it simply high instances of abuse?

In that case, y havent pharma companies completely banned opiates, amphetamines (including meth or desoxyn), & benzos, which all are commonly abused, but like quaaludes have legit medical purposes?

Did benzos replace ludes?

[0utrider]

yes they did, as they replaced barbiturates, prolly because the LD50 was a lot higher with benzos. it was quite easy to kill oneself with the others

[0utrider]

please report back, SWIY!

[Mish]

Nothing. SWIM took a total of 800mg on an empty stomach with no effects. Really annoying.

[rocksmokinmachine]

Originally Posted by Mish

Nothing. SWIM took a total of 800mg on an empty stomach with no effects. Really annoying.

Very strange indeed, etaqualone is structurally similar (almost indentical infact) to methaqualone.

It would be interesting if someone who knows a little more about chemistry than SWIMself to comment on this, and perhaps provide an explanation as to why this may have happened.

[Mish]

SWIM is guessing it is some personal enzyme deficiency, although others have reported almost no effects as well. SWIM is giving up on the Quinazolinone family, as it just doesn't seem to be working for him...

Shame, as SWIM thought it sounded like the perfect downer tailored for him.
Still, any SWIY's out there who've tried this stuff - please report. It's always good to have other subjective info...

[rocksmokinmachine]

After time spent in South Africa (Jo'Burg), SWIM came across 'Mandrax' being sold on the street. After unwrapping the package the pills were stamped and colourful (as ecstasy tablets would be), he thought he'd been ripped off.

After doing a little research he came across something like this site.

xxxx

I think this was actually the site, ehh. SWIM's experience (smoked), as seems to be the most common method of injestion over there. Was FANTASTIC. Being a lover of benzo's, and barbs. This was one of the best things SWIM has ever felt. It was like a huge RUUUUUSHHH that floored him, he Can't remember much after that.

[0utrider]

what.. that IS strange..

[Codehead]

So has anyone got succeful try outs with this one? Seems interesting chemical.

[DynoMiTe]

My Buddha statue tried 603mg last night to no effect, smoked 115mg for a slight rush for 5 min that's it. Not worth the money.

[Mish]

603mg is a high dose... SWIM was wondering (as it has been such a while since his pet giraffe ventured into Methaqualone analogue-territory): is that a high dose/borderline seizure-risk...? Or would that be normal?

SWIM's friend remembers issues with MMQ and potential for seizures - not that any problems ever arose - but he remembers getting nothing from Etaqualone, even though it's supposed to be a closer and thus more potent analogue, but didn't want to push the boundaries too far.

Was SWIY's Buddha aware if this was an "old" batch or a possible "new" batch of EQ; as the "old" was renowned for having issues with purity and efficacy, or so SWIM heard...?

[DynoMiTe]

It was a new batch from a different vendor, he started stocking it about a week before I bought it and to my Buddha's knowledge never stocked it before.

[DynoMiTe]

My Buddha statue is going to go balls to the wall (DO NOT REPEAT THIS) I plan on talking about a gram sniffin 250mg and will prolly throw a 100~mg into a pipe to try and vape. Hopefully my poor statue wont die.

DynoMiTe added 849 Minutes and 0 Seconds later...

@ bad rep. It wasn't advice I was telling my Buddha's plan.

Within a hour My Buddha statue iinsuffulated 250mg, smoked 115mg, and bombed 990mg. and Blacked out. Going to have to work on the doses But he also took 2 3/4 xanax bar earlier in the day.

Reputation Comments on this post:

Dangerous advice (even though you say don't repeat this) and you self incriminate in your post

[Codehead]

SWIM has tested this with doses 400-500mg, and found that 500mg is good dose. Also he has combined it with codeine, ephedrine and weed, it has great synergy with all of them. Its way too expensive for one dose, but he likes it.

[rocksmokinmachine]

Originally Posted by DynoMiTe

My Buddha statue is going to go balls to the wall (DO NOT REPEAT THIS) I plan on talking about a gram sniffin 250mg and will prolly throw a 100~mg into a pipe to try and vape. Hopefully my poor statue wont die.

DynoMiTe added 849 Minutes and 0 Seconds later...

@ bad rep. It wasn't advice I was telling my Buddha's plan.

Within a hour My Buddha statue iinsuffulated 250mg, smoked 115mg, and bombed 990mg. and Blacked out. Going to have to work on the doses But he also took 2 3/4 xanax bar earlier in the day.

I'm interested in this actually. Could SWIY elaborate on the methods used to smoke the etaqualone. Methaqualone is smoked in South Africa on top of marajuana in 'Dagga' pipes.

[DynoMiTe]

Originally Posted by rocksmokinmachine

I'm interested in this actually. Could SWIY elaborate on the methods used to smoke the etaqualone. Methaqualone is smoked in South Africa on top of marijuana in 'Dagga' pipes.

He started sprinkling some on weed then by the end of the night My Buddha Statue was packing bowls of powder. Vaping it by holding the lighter over it and slowly inhaling.

[rocksmokinmachine]

Originally Posted by DynoMiTe

He started sprinkling some on weed then by the end of the night My Buddha Statue was packing bowls of powder. Vaping it by holding the lighter over it and slowly inhaling.

And what effects did your buddha get, what dose?

[laff]

when swim used to smoke buttons (mandrax) back in the day we used to mix it with weed grind it up into fine powder then mix in so it was evenly coated to get the best buzz Swim has tried it without the weed and didnt get much from it so maybe thats the answer to getting the best from RC's

[Guigz]

Swim tested etaqualone a few week ago.

Ingest:
First try: allergic test 10mg maybe, 2hours after, 200mg...nothing.
The day after, 400mg...nothing.

Humm...swim decided to wait a couple of day for continue his test.

Second try: 500mg, empty stomach, no drugs during three days...nothing.

He was very septical about this stuff, especially because he saw some report about the same chemical, buy on the same lab.

1gr, empty stomach, the day after the 500mg test...nothing.

Smoke:

It was HCl form, etaqualone can be smoke on this form so...

200mg in a crack pipe...nothing.
500mg...nothing.

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