Does grapefruit juice potentiate Suboxone for recreational use?

[Herbal Healer 019]

SWIM has some suboxone on their hands and uses .5-1mg to get high off & knows grapfruitjuice potentiates opiates and benzos..But what about suboxone?

Does the nalaxone effect the buprenorphine in suboxone at low doses (.5-10mg) & how would GFJ interact with the nalaxone?

[tryptamaster]

gfj potentiates beznoz??? really??? is here any pharmological or psysiological evidnce for that?

[Herbal Healer 019]

GFJ inhibits CYP3A4 enzymes which are responsible for metabolizing certain drugs including several benzos

[tryptamaster]

like u know wat benzos? alprazolam, diazepam, clonazepam? jw

[Herbal Healer 019]

Most drugs metabolised by the cytochrome P450 system of liver enzymes are potentiated by GFJ. GFJ inhibits the CYP3A4 enzyme resulting in a diminished first pass metabolism with higher bioavailability and increased maximal plasma concentrations of substrates of this enzyme, especially in certain, if not all, benzodiazepines & some opiates to my knowledge.

Benzos potentiated by GFJ: Alprazolam (xannie), Diazepam (valium), Lorazepam (ativan), clonazepam (klonopin)

Not sure if the list is complete.

[tryptamaster]

well u mentioned the most often beznoz swiys use for recreatio so id assume that covers most peoples concerns.

[superdupernaut]

Originally Posted by Herbal Healer 019

SWIM has some suboxone on their hands and uses .5-1mg to get high off & knows grapfruitjuice potentiates opiates and benzos..But what about suboxone?

Does the nalaxone effect the buprenorphine in suboxone at low doses (.5-10mg) & how would GFJ interact with the nalaxone?

Yes, buprenorphine is metabolized by cyp3a4 therefore GFJ will further inhibit the metabolism of this already long-lasting drug.

I don't beleive that naloxone is processesed in the same way, but I'm not sure. If taken as directed (sublingually) the naloxone is pretty much rendered ineffective.

Also the bupe has a higher affinity for the mu-receptors than does the nalaxone so (assuming your not all dosed up on other opiates) you probably wont notice the naloxone very much.

[Herbal Healer 019]

w8 hold up so if SWIM crushes and plugs or snorts the suboxone, the nalaxone will block the high? Because SWIM did both ROA and both times was incredably faded although nauseaous; possibly the nalaxone at work?

thanx 4 the reply

[superdupernaut]

A shallow snort should keep the nalaxone out, I dont know about rectal. Swallowing / IV will let the nalaxone in. But from what I understand (and swims experience) the nalaxone isn't very effective at blocking the high, (especially in those without a habit).

[Herbal Healer 019]

So would the nalaxone have been responsible for SWIMs excorcist-style projectile vomiting that preceded their last post? lol

[superdupernaut]

Hell if I know.

Lots of people puke when they take a sizeable dose of a strong narcotic.

[TheSpeedBall32]

So there's ways to prevent the Naloxone from operating when taking Suboxone? I heard a bit back that Naloxone is only in the 8mg tabs, & not in the smaller 2mg tabs, but I believe this to be wrong IMO.

[chukbzle]

its a real tiny amount ,ive heard if u dont swallow the last bit of liquid or any at all and i think the naloxone is inactive that way .like so u dont snort shoot or just eat a bunch i thinks its only soluble if its not put under the tongue .i might be wrong but pretty sure