Effects - Benzo's and Nicotine

[heroin_ed]

SWIM is aware the nicotine decreases alprazolam's effects by 50%.

Does nicotine decrease the effects of clonazepam, diazepam, or temazepam?

SWIM is mainly interested in knowing if nicotine decreases clonazepam's effects as he just got a script for it yesterday.

He also gets temazepam and diazepam occasionally and would like to know about nicotine's effects on those benzo's as well.

[Jatelka]

There's an interesting article in the archive here...

http://www.drugs-forum.com/forum/loc...tid=98&id=3237

which looks at smoking and benzodiazepine pharmacokinetics (among other psychotropic drugs)

[Laudaphun]

Originally Posted by heroin_ed

SWIM is aware the nicotine decreases alprazolam's effects by 50%.

Does nicotine decrease the effects of clonazepam, diazepam, or temazepam?

SWIM is mainly interested in knowing if nicotine decreases clonazepam's effects as he just got a script for it yesterday.

He also gets temazepam and diazepam occasionally and would like to know about nicotine's effects on those benzo's as well.

SWIM compared the package inserts for clonazepam and alprazolam and the clonazepam insert stated that nicotine would reduce the effects of clonazepam, while the package insert for alprazolam did not mention anything about nicotine affecting the absorption or effect. It was just a casual observation.