Effects - A question about grapefruit juice and hydrocodone polistirex

[heroin_ed]

SWIM was just prescribed Tussionex for his cough which I'm sure most of SWIY know is hydrocodone polistirex. Will grapefruit juice potentiate hydrocodone polistirex?

[fiveleggedrat]

Actually, the polisterex will fuck up the dosing, if it's anything at all like DXM poli.

Expect reduced potency and feelings but increased duration; it's an extended release coating on the hydrocodone.

[heroin_ed]

SWIM knows this, but will the grapefruit juice increase the effects as if it were hydrocodone hbr?

[JarvyJarvison]

Why doesn't SWIY try it and let us know?

[JarvyJarvison]

Tussionex®
Pennkinetic®
(hydrocodone polistirex and chlorpheniramine polistirex) Extended-Release Suspension  

[top]DRUG DESCRIPTION

Each teaspoonful (5 mL) of TUSSIONEX Pennkinetic Extended-Release Suspension contains hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate and chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate. TUSSIONEX Pennkinetic Extended- Release Suspension provides up to 12-hour relief per dose. Hydrocodone is a centrally-acting narcotic antitussive. Chlorpheniramine is an antihistamine. TUSSIONEX Pennkinetic Extended- Release Suspension is for oral use only.

[top]Hydrocodone Polistirex

Sulfonated styrene-divinylbenzene copolymer complex with 4,5α-epoxy-3-methoxy-17- methylmorphinan-6-one.

[top]Chlorpheniramine Polistirex

Sulfonated styrene-divinylbenzene copolymer complex with 2-[p-chloro-α-[2- (dimethylamino)ethyl]-benzyl]pyridine.

[top]Inactive Ingredients

Ascorbic acid, D&C Yellow No. 10, ethylcellulose, FD&C Yellow No. 6, flavor, high fructose corn syrup, methylparaben, polyethylene glycol 3350, polysorbate 80, pregelatinized starch, propylene glycol, propylparaben, purified water, sucrose, vegetable oil, xanthan gum.

The time-release mechanism means SWIheroin_ed will have to take a lot more hydrocodone for recreational benefit than normal, but it will last longer. Be mindful that chlorphenamine is an anticholinergic antihistamine that is the primary culprit in "Trple-C" related deaths (Corcidin Cough & Cold). Be careful.