Pharmacology - Amphetamine tolerance

[sknkv2]

(SWIM used search engine)

How quickly does tolerance to amphetamines develop from your SWIM's experience? Any studies would also be appreciated. He is interested to know how much one needs to use in order to become tolerant and for how long. Also, how long does it take for tolerance to go away. Thanks.

Reputation Comments on this post:

	Thanks for bringing this up.
	This is very scarce topic. Thanks for bringing it about

[humdroid]

Y has experience with base only. The stuff the brits use for a lift.
Whatever dose is taken, the next dose has to be double.
A good few weeks is preferable for non use, so that tolerance has a chance to lower.
In a nutshell, tolerance builds up very quick, and takes ages to reduce.
Y presumes ditto for methamph, but is not sure on this.

[SWIMming]

To agree with SWI Insert Name Here, tolerance developes essentially immediately (cross tolerance with other stims, Amp, Methamp, cocaine, X, etc, etc, included).

Basically, after the fist dose, the SHORT TERM tolerance is SKYROCKETED for 2-6 dys (in SWIM's experience), and long(er) term tolerance is upped for at least a week, typically several weeks for tolerence 'gained' via heavy/binge use, or use of stronger stims (tolerance to Amp from Cocaine or MethAmp, etc).

Hope this is helpful!

[Psychoactive Lab Rat]

Odly enough however, adding a magnesium supplement of around 500mg to your daily diet 3 days to a week before starting an amphetamine binge and during the binge will (incidental and SWIM's experience) completely halt amphetamine tolerance all together.

There's extracts around the net somewhere explaining magnesium's role of being a partial NMDA blocker. Blocking/ Partially blocking NMDA seems to work in some cases to even totally reverse tolerance. Experience report wise I have read of some which this hasn't worked...

There are better NMDA blockers out there too, just not as available as magnesium.

Reputation Comments on this post:

Awesome info. Thanks much.

[Hollow Hippie]

Originally Posted by Psychoactive Lab Rat

Odly enough however, adding a magnesium supplement of around 500mg to your daily diet 3 days to a week before starting an amphetamine binge and during the binge will (incidental and SWIM's experience) completely halt amphetamine tolerance all together.

There's extracts around the net somewhere explaining magnesium's role of being a partial NMDA blocker. Blocking/ Partially blocking NMDA seems to work in some cases to even totally reverse tolerance. Experience report wise I have read of some which this hasn't worked...

There are better NMDA blockers out there too, just not as available as magnesium.

And what exactly does NMDA have to do with amphetamine? Swim finds the magnesium tolerance lowering theory sounding like to much unsourced crap claims.

[cobetcknncoio3]

SWIM dosed 50mg on wednesday, 50mg on thursday, and hasnt had any today. will he still get anything out of it if he does another 50mg tomorrow? will upping it to 75+ help?

[dark12]

Amphetamine tolerance is caused by excess Ca++ influx through the NMDA receptor gated calcium channels on the outer membranes of the dopamine cells bodies in the ventral tegental area, one of two areas in the brain with concentrations of dopamine producing neurons.
As alluded to above, taking an appropriate NMDA* (partial) antagonist will prevent the development of a tolerance for the effects of an amphetamine or amphetamine-like stimulant. Also, by preventing excess Ca++ influx into the neuron, an NMDA antagonist will prevent associated brain alterations and damage (excitotoxicity).

Magnesium is an NMDA antagonist. Most people are deficient in magnesium, and stress reduces magnesium levels. Whether or not one takes amphetamines, magnesium supplementation is very important for mood, general well-being and keeping stress levels under control. It is also important to take magnesium in efficient form, with adequate bioavailability. The best type is magnesium glycinate (chelated) with bioavailability at around 80%.

SOURCE: http://www.addforums.com/forums/showthread.php?t=9575

This is a very interesting topic indeed. SWIM thanks SWIy for bringing this to his attention.

EDIT: 300th post! woot!

[Hollow Hippie]

Congrats, SWIY made SWIM look stupid. This is an interesting topic, just goes to show how many examples of addiction and reinforcement mechanisms that almost appear to be hardwired in there. Well, SWIM will defiantly start taking magnesium, because ironically, SWIM has been emptying 1000 mg magnesium caps out and putting amphetamine in them. Huh, SWIM has to wonder if dextromethorphan or even nitrous oxide would be effective also?

Hollow Hippie added 1 Minutes and 28 Seconds later...

"that almost appear to be hardwired in there...", SWIM meant to say our brains and bodies.

[holku]

Originally Posted by Hollow Hippie

Congrats, SWIY made SWIM look stupid. This is an interesting topic, just goes to show how many examples of addiction and reinforcement mechanisms that almost appear to be hardwired in there. Well, SWIM will defiantly start taking magnesium, because ironically, SWIM has been emptying 1000 mg magnesium caps out and putting amphetamine in them. Huh, SWIM has to wonder if dextromethorphan or even nitrous oxide would be effective also?

Hollow Hippie added 1 Minutes and 28 Seconds later...

"that almost appear to be hardwired in there...", SWIM meant to say our brains and bodies.

well i dont think SWIY actually looked that stupid. The whole Magnesium/NMDA antagonists in amphetamine tolerance prevention/reversal is pretty much all sourced to one post made by a guy about 5 years ago on bluelight and then copy pasted throughout addforums etc forever since. Everything about is strung together by a bunch of dubious claims from a couple of studies not really related to the topic and some other unsourced stuff. From my own research into the topic NMDA antagonists seem to be of limited efficacy in the treatment/prevention of opioid tolerancewhere it is much more researched than amphetamine tolerance and seems to be work less well in that case. The best anecdotal evidence to be found is a few posts of people saying "SWIM has been using magnesium for a couple of days and SWIM feels better!".

[TestPattern]

Originally Posted by Hollow Hippie

Congrats, SWIY made SWIM look stupid. This is an interesting topic, just goes to show how many examples of addiction and reinforcement mechanisms that almost appear to be hardwired in there. Well, SWIM will defiantly start taking magnesium, because ironically, SWIM has been emptying 1000 mg magnesium caps out and putting amphetamine in them. Huh, SWIM has to wonder if dextromethorphan or even nitrous oxide would be effective also?

Hollow Hippie added 1 Minutes and 28 Seconds later...

"that almost appear to be hardwired in there...", SWIM meant to say our brains and bodies.

Swim has read on a number of occasions about people using DXM to combat amphetamine tolerance, so SWIM would wager a guess that yes, it could be used for this purpose.