Pharmacology - Different pills different receptors..

[chukbzle]

Does any Swimmers have any data or clue or idea what pills light up the best parts of your brain, like opiates is swims aim here , like morphine has a nice feel ,but oxy has a great one too, is there certain ones that use receptors others dont? like a Dilaudid and an MScontin? or fentanyl with poppy tea? or a small amount of a few producing a better outabody time? scientist or not swim would love to hear what you guys have came up with.

1 swim recently liked :drinkin a lil pod tea with OCs then a huge opium blast at end with a safe dose of klonipin and some GF juice swim thought it was great he said.

Is there a data sheet that shows how each has its strengths and weaknesses ? swim is still searchin and will gimme the info to post if its found

[aromaticalcohol]

Ok, every opioid that produces the classical opium like effects (euphoria, mild sedation, pinned pupils, itching, nodding, pro-sociability), is an agonist a the mu opioid receptors.

From now on in this post, mu opioid recepts = MOR, kappa opioid recepts = KOR, delta opioid recepts = DOR.

There are two subtypes of MORs, 1 and 2. mu1 produces the pain relief, euphoria, some of the physical dependence and some of the sedation, mu2 produces some analgesia (not as much as mu1), most of the sedation, most of the physical dependence, and most of the respiratory suppression. MOR agonists that slightly prefer mu1 tend to be more enjoyable.

The other opioid receptors also come into play. You don't want too much KOR agonism. KOR agonists tend to cause dysphoric and overly tired and spaced out feelings, with mild hallucinations at high doses.

DORs aren't as well understood as MORs and KORs. It's though though that weak affinity as a DOR agonist or partial agonist increases enjoyability and analgesia, but that strong DOR agonism causes very significant respiratory suppression without any added analgesia or euphoria over the weaker agonists.

So the ideal opioid would probably have this profile:
1)full MOR agonist, with a preference / higher binding affinity at mu1 subtypes

2)KOR antagonist. This one would be tough since most MOR agonists are weak KOR AGONISTS, although mostly not enough to ruin the euphoric MOR agonism high (pentazocine is an exception... lots of KOR agonism, hence a pretty nasty drug). I think a KOR antagonist that is also a MOR agonist could be made though, it just might be awhile before we see one out there.

3)DOR partial agonist. Many MOR full agonists are weak full agonists at DORs too, but I think a full mu agonist that is a partial agonist at DORs would be best.

Throw in MILD NMDA antagonism (like ketobemidone) and you've got a winner. An opioid with these traits would likely be highly, highly euphoric and addictive.

To answer your question though, yes, each MOR agonist does differ a bit in it's particular binding affinities for the different types and subtypes of opioid receptors. That's what gives opioids thier "personality" even though they all feel very similar... how experienced users can tell one from another even though they feel extremely similar.

Reputation Comments on this post:

	good post
	very good rundown

[chukbzle]

that was a perfect answer thank you .also a good post to have here

[stupidorange]

Sorry to bump such an old topic, but I'd be extremely interested to know what opioids affect what receptors. Our theoretical "ideal opioid" up there - what matches it best, for instance?

[fiveleggedrat]

You know, Swim has lost most action on m1 due to tolerance that never disappears, but Swim wonders if adding delta stimulation is the answer; Swim will obtain kratom again soon and experiment; it might be the way to bring euphoria back.

[stupidorange]

Kratom worked very well in eliminating WDs for my friend, so I think you might be on to something.

(I wish I could edit posts... just noticed I've been reading the dates wrong. "Wow, all of these threads were made on the 11th of July!")

[aromaticalcohol]

Originally Posted by stupidorange

Sorry to bump such an old topic, but I'd be extremely interested to know what opioids affect what receptors. Our theoretical "ideal opioid" up there - what matches it best, for instance?

I'd be very interested to know this, too. I'm confident that the traits I described above would make the ideal euphoric opioid, but I'm really not sure which opioid, of the ones we already have, is the closest match.

I know buprenorphine is a KOR anagonist, but it's only a MOR partial agonist, which ruins it as a recreational drug. Only opioid naive people would get a really good buzz from it. Its KOR antagonist / MOR partial agonist properties make it an extremely powerful antidepressant though; I'd love to see bupe accepted as an anti-d for treatement resistant depression, but I doubt the gov't of western nations today would accept it. They're too opiophobic. It's sad, because so many people could be helped.

Ketobemidone has the mild NMDA antagonism and that does seem to help make it one of the most euphoric opioids out there, but I'm not sure about its other receptor actions. It's obviously a full MOR agonist, but IDK how it acts at KORs or DORs.

[stupidorange]

Originally Posted by betsym

11th of July? IF that were the case, then all the recent posts with the 11 in the middle would have neen made in July and swim doesn't think that's true.

You are correct; that's what made me finally realize it was going day/month/year instead of the more usual (in the U.S., that is) month/day/year. That, and seeing dates like 13/10/08... "Thirteenth month, tenth day?! What?!" :P

[jon-q]

Originally Posted by stupidorange

You are correct; that's what made me finally realize it was going day/month/year instead of the more usual (in the U.S., that is) month/day/year. That, and seeing dates like 13/10/08... "Thirteenth month, tenth day?! What?!" :P

The UK and The USA use different date formats for example~
UK= 25/12/2008 = USA= 12/25/2008
regards.....q