Loperimide for easing opiate withdrawal???

[dralph]

I heard from a freind that using high doses of loperimide really eases the withdrawal symptoms of opite addiction. I was told that doses of 48mg to 100mg were acceptable depending upon the severity of the problem. You apparently then wean off of the loperimide over time and all is good to go? Has anyone heard of this before?

[chillinwill]

Loperamide helps with the diarrhea associated with opiate withdrawal. It does not cross the BBB (blood brain barrier) and acts on the μ-opioid receptors and not the central nervous system. I have never heard of doses that high and doses that high of Loperamide might be in fact quite dangerous.

As far as trying to avoid the withdrawal symptoms of opiates, there are several ways to do this using methadone or buprenorphine. Try searching the forums for more information on this as there is a plethora of information on them.

[fiveleggedrat]

Fuck those doses, way too high.

Start with 4mg, and go in 4mg increments. Don't go over 30-40mg. You wont shit for days.

10mg has Swim on hold for 1-2 days, hardcore. Intestinal mobility pretty much stops altogether.

But yes, loperamide can help with w/d's because it is an opioid, albeit one that does not cross the BBB, so it'll help with the physical symptoms from w/d.

[dralph]

Sounds like a sure way to toxic megacolon as mentioned in one of the other replies. All of them were good info and I feel loperimide is a little chancy at those doses. Probably need a crowbar to move things along....if you know what I mean. Thanks for the reply!!

[lorzapmail]

Fiveleggedrat knows whats going on. Do this if you didn't get his post. Get Imodium (lorermide).Note: Lorermide was the hope of the new pain killer when delevoped, sadly, it did not work). Liquid is better but pills will work. Take 4 mg every 4 hours. Get plenty of vitamin B, potassium, sun shine, sleep,Alieve may help leg pain. Three day or so you will be okeedokee and then try to deal with the mental problems.This is all been on the web for years.

[Dickon]

I found this on another unnamable site (BBB=brain blood barrier)

"Loperaminde along with Cereport, which increases permeability of the BBB, has been shown to produce clear analgesic effects.

I also have heard p-glycoprotein inhibitors get it across the BBB more effectively.

The other option is delivery of loperamide with polysorbate-80 coated nanoparticles."

The polysorbate-80 coated nanoparticles information is also on wiki; although except for the chemists out there, I'm not sure quite how feasible nanoparticularizing loperamide and then coating the nanoparticles in polysorbate-80 is! It seems, from looking around, that some people do experience euphoria/abatement of w.d.s using just a high-dose (I've seen a maximum dose of 340mg - i.e 170 2mg pills, but 30-100mg seems normal, for this abnormal use at any rate). Perhaps just a little does cross the BBB, and whacking up the doses will work. I've never tried using the stuff in these doses or for these reasons, and make clear than I do not advise anyone try this at home, without doing thorough research on the safety. I should add I've come across a couple of posts elsewhere that mention neurotoxicity of loperamide if it gets through the BBB along with posts discrediting such information. Research! Research! Research! No high / abatement of w.d.s is worth being turned into a vegetable for.

I'd be interested to hear what you (or SWIY) makes of it, if you try dralph. Please post!

D

[fiveleggedrat]

Swim has done lengthy experiments with lopermide. It's not worth experimenting with.

The polysorbate 80 thing is lab grade work.

P-glycoprotein inhibitors do help it pass the BBB, but to a VERY minute degree, based on Swim's experience. Ketoconazole and quinidine are a few.

The only people who gets effects from high dose loperamide have EXTREMELY low opioid tolerances, like those who are opiate naive, eg never had any.

Swim HIGHLY suggests never taking a dose of 50, maybe 100mg per 24hours. Ever heard of Toxic Megacolon?

Side effects can include drowsiness, constipation, abdominal pain or discomfort, dry mouth, fatigue, and in rare cases toxic megacolon, mild euphoria and mild stimulation (at high doses).

"High" doses of this stuff, medically speaking, are DEFINATELY under 100mg. Anyone taking over 100mg is really an idiot, or just does not know better.

Swim has smoked, eaten, plugged, sub-l, etc this shit, and ALL it does is produce CNS depression and cause severe intestinal immobility, eg, non-moving gut pretty much. The few people who get effects from it take a single Vicodin and are set to nod.

Swimmers, this stuff is not recreational, trust me. For W/D's, keep the doses small as possible. Use only what helps and no more. Using this everyday for a while, especially with anything higher than the 4mg recommended dosage will end up causing septic shock and toxic megacolon. It's also rather painful

I personally suggest kratom for w/d's. Penetrates the BBB so it's much more effective.

I don't have a source for this, but I would think smoking loperamide to be dangerous.

If Swim could do the poly80 thing, he'd give it a shot.

The ratio of mental effects (euphoria, etc) Vs Physical (sedation, constipation, etc) are significant. Even crossing the BBB, still not very strong.