Drug info - History of methadone and origins of its former name "dolophine"

[Panthers007]

Parke-Davis Pharmaceuticals will call out it's fascist dogs to pounce on any attempts to curb the use of methadone. As long as they have a financial incentive. So McCain will likely bomb Canada if Canada goes to the next, logical step: Replacing methadone with heroin or hydromorphone. Either of which has fewer nasty side-effects than does Dolophine - named after Adolf Hitler and renamed 'methadone' after the war.

Reputation Comments on this post:

	Sadly, you are right.
	Wrong about Dolophine. It was derived from the latin meaning roughly an end to pain

[inj3n]

Originally Posted by Panthers007

Parke-Davis Pharmaceuticals will call out it's fascist dogs to pounce on any attempts to curb the use of methadone. As long as they have a financial incentive. So McCain will likely bomb Canada if Canada goes to the next, logical step: Replacing methadone with heroin or hydromorphone. Either of which has fewer nasty side-effects than does Dolophine - named after Adolf Hitler and renamed 'methadone' after the war.

swim obviously owes this thread an apology over the above quote, swim had some memory loss about a thought to be research paper from school years back turned writing. swim found this paper and realizes it is a writing project referenced from non-fiction turned fiction. That was the obviously the bottom of Swim's bottle shining thru. Swim's rambling regarding the above quote were misguided. Swim methadone experience is by far not fiction. SWIM would never wish anyone be chemically dependant on methadone.

This reference explains what needs to be said

Ralf Gerlach: A Brief Overview on the Discovery of Methadone. INDRO e.V. Münster 2004

Reputation Comments on this post:

	As a newbie i will be kind!Be sure of "ALL" your facts.swiy did make SOME good points.pity about the bad ones.
	propagating unfounded myths

[Panthers007]

Excellent read regards the Nazi uses and enslavement. If you can find sources and articles/papers on this - it would make a great addition to the archives here.

Thanks again.

[G_nome]

Yeah, i'll second that.

[jon-q]

Originally Posted by Panthers007

Dolophine - named after Adolf Hitler and renamed 'methadone' after the war.

Please mr panthers007 do not "wipe out" swim..Q's rep but i feel i must pull up this quote! "It is a urban myth"?
Fact=Methadone was developed in germany in the late 1930's,The Nazi partys concern's of opium shortages due to the impending war "Typical German efficiency" Possible enemy blockades e.t.c would lead to limited amounts of Morphine and codeine e.t.c for military and civilian? populations.It is well documented that an endless supply of "unwilling" humans suffered greatly in the researching of methadone's potential "Pain blocking effects".
However it was decided that due to it's highly addictive qualitys it would only have a limited potential for repeated use in the military.
The drug was originally named DOLOPHINE in 1947(see Eli Lily),dolor in latin=pain,many pain relieving drugs arond this time used "dol" within their names.
Thus it was NOT named BY or in respect of ADOLF HITLER.
Urban myths=It has and still is claimed that (Methadone originally named Dolophine) was given this name in respect for Adolf Hitler other myths claim the very first names given to this drug were-"Adolphine or Adolophine" **this claim is still held by church of scientology literature**
The name Dolophine came about in 1947 and was given this Trade name by Eli Lily and CO,Methadone as "Dolophine" was first manufactured in the usa by Mallinckrodt Pharmaceuticals swim believes thet held the patent up until 1990?? **source Entertainment weekly interview with Tom cruise.
Much of this info has come from "The world at war",Nation Master-encyclopedia,wikipedia and many wasted years as a teenager looking up to the above mentioned BEAST as some kind of misunderstood person.SWIM WAS WRONG VERY WRONG.
Drugs of many kinds have been used in wars throughout history inc the above mentioned methamphetamine.Swims research shows that it was used by the "LUFT-WAFA" to prevent sleep on long bombing raids,As did the "R.A.F" on similar bombing raids amphetamine sulphate?swim thinks!
From Gengis-khan,napoleon through to modern day warfare Drugs have and no doubt will been used with Good and Bad intentions.
Swim hopes this adds some info to this debate!
Regards .....Q
Swim will post some "truths" about the nazis use of said drugs and that aint aimed at 007!

Reputation Comments on this post:

finally able to give you rep. for your excellent post.

[drug-bot]

Originally Posted by Panthers007

Either of which has fewer nasty side-effects than does Dolophine - named after Adolf Hitler and renamed 'methadone' after the war.

dolophine was not named after hitler, your propagating a long discredited and easily disprovable myth. only scientologists (and those who know very little about the topic) still cling to the myth.

panthers are you a scientoligist, or better yet Tom Cruise)

On September 11, 1941 Bockmühl and Ehrhart filed an application for a patent for a synthetic substance they called Hoechst 10820 or polamidon (a name still in regular use in Germany) and whose structure had no relation to morphine or the opiate alkaloids (Bockmühl and Ehrhart, 1949).

^ bold quote mine to show how nazi germany didnt call methadone Dolophine.

Origin of Dolophine name
A persistent but untrue urban legend claims that the trade name "Dolophine" was coined in tribute to Adolf Hitler by its German creators, and it is sometimes even claimed that the drug was originally named "adolphine" or "adolophine" or "Dolphamine". The claim is still presented as fact by Church of Scientology literature[1] and was repeated by actor and vocal Scientologist Tom Cruise in a 2005 Entertainment Weekly interview.[2] However, as the magazine pointed out, this is not true: the name "Dolophine" was in fact created after the war by the American branch of Eli Lilly,[3] and the pejorative term "adolphine" (never an actual name of the drug) appeared in the United States in the early 1970s.[4]

^bold print my doing
http://en.wikipedia.org/wiki/Methado...Dolophine_name

Originally Posted by inj3n

Yes after doing extensive research on methadone and deciding to quit do to the knowledge SWIM gained, the research SWIM found on Dolophine and how, if SWIM remember correctly, Hitler had some of his top scientists manufacturer this drug to give to his most elite soldiers who carried out gruesome tasks. These "Elite Soldiers" were supposidly so terrified of not being able to get thier daily dosage of Dolophine after they were forced to become chemically dependant on it and feared the withdrawals symptons that they witnessed from othe soldiers, that they basically told themselves they had no choice but to carry out the horrific orders that Hitler set for them. Keeping them on dolophine and amphetamine, basically clouded the pains of combat fatigue and lack of endurance to give them the name "Elite Soldiers".

Originally Posted by Panthers007

Excellent read regards the Nazi uses and enslavement. If you can find sources and articles/papers on this - it would make a great addition to the archives here.

Thanks again.

also untrue, methadone wasnt used as a type of enslavement, in fact the germans stopped using it before the war was over because they deemed it too addictive and too toxic (no other studies shows its toxicity, so they were proberbly refering to its long half-life and therefore long withdrawl period0

also as a side note inj3n id like to see some of your 'extensive research'

Methadone was developed in Nazi Germany in the late 1930s in anticipation of possible shortages of raw opium during the upcoming war and possible blockades by the enemy, which would result in shortages of morphine and other opiates for both the military and civilian populations. It was tested by medical professionals in the German military in 1939-40 but decided that it was too toxic and too likely to become addictive upon repeated use (habituation) for use in the army and other organisations.

http://en.wikipedia.org/wiki/Methado...Dolophine_name

[Pope Albacore]

We'll see how long this free thinking is allowed to run its course. SWIM says that according to his junior SS handbook that ,"Zee people shall not think for zemselves without proper permit...". So...there.

SWIM says that this study shows progress but after years of BS in the media and by so called "experts" no less, it is just a ripple on a wave. SWIM says it is a start but you can't have progress from one report alone. If there was only a way to outlaw ignorance...

-Pope Albacore

Reputation Comments on this post:

Zee have wazze of mikinzee talk

[Panthers007]

Do keep reading. And answer this question: Why would a western pharmacuetical company, after a horrible war to get rid of Hitler and the Nazis, name their new drug 'dolophine' that is an obvious salute to Adolf Hitler?

The German supply-lines for opiates were cut off by the allies during WWII. This is why this substance was trotted out for use as an analgesic. The next, sometimes called first, synthetic opiate to appear wasn't until the 1950's - meperidine (Demerol in USA, Pethidine in the UK). Regards the story by inj3n, I am curious and asking the person to bring forth articles to back this up. It is interesting from a historical perspective.

Reputation Comments on this post:

please stop saying easily dipsellable myths about how diolophine named was in honor of hitler. it doesnt help in the goa...

[drug-bot]

Originally Posted by Panthers007

Do keep reading. And answer this question: Why would a western pharmacuetical company, after a horrible war to get rid of Hitler and the Nazis, name their new drug 'dolophine' that is an obvious salute to Adolf Hitler? .

No its not obvious, its paranoia. firstly you can break the word dolophine down, dolor means pain in latin and fin is a french word which means end so it was americanized to phine, methadone effectively kills (ends) pain. secondly eli lilly who patented dolophine (in 1947, two years after the war) was operated here in the u.s, though now its international its headquaters are still in the u.s. thirdly during ww2 eli lily supplied the alies with much needed plasma and other medications, they had no connection to hitler or nazi germany. fourthly dolophine doesnt really resemble adolph in the least, fuck it, its more plauseable (if looking at resemlances in names) that when Nostradamus mentioned the hister river that he meant hitler (lots of nuts beleive this).

no offence panthers you are one of swims favorite posters but your just plain and completely wrong on this one.

[jon-q]

This myth didn't start until the 1970's
Here's two links just to get swimmers starterd i will start a more suitable thread and post many more links,linking drugs to warfare at a latter date!
http://www.spigel.de/international/0...354606,00.html
http://www.disinfo.com/archive/pages...pg1/index.html
Regards.....Q
Note a small box may appear on the second link in the centre of your screen simply click the x square in top right hand corner of said small box.

[Panthers007]

In the last analysis it doesn't matter a hoot. They can dress a pig in a sequin gown, but it's still a pig. Produce medical documentaion on the use of this drug from the Germans in 1944 and I'll listen. Anywho - methadone is a shit drug compared to heroin or hydromorphone (or a wheelbarrow of other semi-synthetic narcotics) regards it's dangers of overdose, it's difficulty of withdrawing from those who choose to quit, and the slurring "I'm either a junkie or a drunk" speech-patterns it elicits in users. While not giving the user the euphoria of heroin or hydromorphone, it does present the person as seriously fucked-up on something. This I've seen up close & personal.

So this study will not be welcomed with open arms across the border in the US. Our government prefers it's addicts miserable and easy to spot. And I do know that other drug companies hold the patents on heroin and hydromorphone (Dilaudid) in the global marketplace. Parke-Davis put all it's eggs in the methadone basket and stands to lose considerable financial dividends if other molecules were to creep into the addiction-treatment business.

Regards speed (methamphetamine) - this subject belongs in the amphetamine forum. Where it has been mentioned several times regarding the use of methamphetamine by the German army and Luftwaffe during WWII.

[jon-q]

Swim will try to locate said medical documentation,but as we both well know the majority off any "documentation" will have been destroyed!
swim looks up to panthers007(seriously)but to ask for medical documentation?thats like saying produce proof that it was himmler discussing the elimination of millions of jews in the renowned "himmler recordings" or perhaps 007 thinks that was a fake! swim will continue to post what ever links i can in other thread "DRUGS AND WARFARE"
But i think it best we agree to disagree on this matter.

[inj3n]

not a problem, didnt realize how quick this thread took off, otherwise would have reposted earlier, repost soon. need to dig up research papers from school.

[Routemaster Flash]

Originally Posted by Panthers007

Do keep reading. And answer this question: Why would a western pharmacuetical company, after a horrible war to get rid of Hitler and the Nazis, name their new drug 'dolophine' that is an obvious salute to Adolf Hitler?

Because in all honesty, it doesn't really sound too much like 'Adolph', does it? And wouldn't 'Hitlerine' have been a much more obvious name choice if had been created by Nazi scientists?

Furthermore, I'm pretty sure Hitler would have been keen to promote the image of himself as an invincible Aryan superman, not some weakling who needed to use painkillers!

Edit:

Originally Posted by drug bot

and fin is a french word which means end so it was americanized to phine, methadone effectively kills (ends) pain.

Isn't the -phine ending just a pastiche of the name of the original opiate, morphine?

[msmogadon]

Originally Posted by chillinwill

[imgl=white]Participants also improved their physical and mental health by 27 per cent.

Surely this is the tip of the iceberg. How could this NOT improve these areas?

quote=chillinwill;483976]An untreated heroin addict costs Canada an estimated $45,000 a year in public health care, criminal justice and welfare.[/quote]

An average addicts yearly spenditure lol

And Panthers some people have nothing better to do give regative rep. Its all to to with 'forum power' syndrome Similar to powder power. would roll SWIMs eyes if she didin't look like she'd had a head injury lol bugger SWIM will do it anyway lol
Negative rep is not supposed to be given in diagreements some people should know better

[Panthers007]

"Negative rep is not supposed to be given in diagreements some people should know better"

Correct. And twice in a few hours. Busy, busy.

Well, the USA wants to jail addicts that don't want the DOLOPHINE, or who fall off the methadone-alone wagon. And this costs well over $20,000/year. But they have found cost-cutting measure: Cut out medical-care for their client/inmate. After all, if they opted for a drug (heroin) aside from the government-approved one, that messes up the statistics on the drug's success rate. Can't have that, can we?

Oh, and to the jerk playing bad reputation (because I said you could notice someone on methadone was wigged-out) - maybe you'd like to meet some old friends of mine? Or the street people I know as well - Rabbit, Cosmo, Black Hand, etc (all Vietnam vets). If you can't tell that they are messed-up from their daily dose, don't apply for work as a screener/interviewer. Hiring someone who keeps passing out and puking doesn't go over too well in the workplace. Methadone does indeed cause the person to appear and act very smashed. At least on the doses given to heroin-addicts at government-sponsored clinics.They slur there words, they occasionally stumble, and they keep apologizing for looking messed-up from the drug they are given.

Once again: I don't think the USA will go for the heroin, or hydromorphone, option. Answer me this - why did the US government allow methadone to be used - at the cost of not allowing any others? Now buprenorphine (Suboxone) is being used. Do you know how many years it took to approve this one? And the state it would be used in had to vote and agree to it. That is legislation of medical care. never mind your doctor - call your congressman.

So why was methadone the winner in the heroin-treatment game?

Reputation Comments on this post:

Whilst i have only been around for a short while i thought i had gained a little bit of.we3ll

[drug-bot]

Originally Posted by Routemaster Flash

Isn't the -phine ending just a pastiche of the name of the original opiate, morphine?

it also most likely also comes from the french word fin anglosized into phine. the word means end, as in the end of pain when used in reference to opiates/opiods.

-peace

[mickey_bee]

oh bugger, it's a new page, that means loadsa people won't see my last mammoth.....(and mammothly interesting), post.
Also, stop whining 007, that's very un-bond like. And besides, saying Dolophine was named such as a salute to Hitler is one of the oldest drug myths in the book. It sounds good, and makes a good story, but just isn't true.

[Panthers007]

Get ready to be disappointed then. Even if opiates were found to cure cancer and heart disease, I doubt the respective governments of my and your nation would change the current laws. Call me cynical, but all to often I see the same as you do - it gets ignored.

I hope we're wrong for once.

[Alfa]

Originally Posted by drug-bot

http://en.wikipedia.org/wiki/Methado...Dolophine_name

Wikipedia does not count as proof. I can go into the wikipedia page right now and rewrite it to my likings. Hell, theoretically; you could have written the article. Do you see my point?

Since you both get so worked up about this, I think it is about time for both of you to bring some real proof to the table. Get off yer asses and go to the library, email the involved companies, writers of the articles linked above:
http://www.disinfo.com/archive/pages...pg1/index.html
http://www.spiegel.de/international/...354606,00.html

Or any other source that may contribute to the debunking of or substantiating of this claim.

[ThirdEyeFloond]

The History of Methadone

Ralf Gerlach©: A Brief Overview on the Discovery of Methadone. INDRO e.V. Münster 2004


Methadone was first synthetized in 1939 at the pharmaceutical laboratories of the I.G. Farbenkonzern, a subsidiary of the Farbwerke Hoechst, Frankfurt am Main, Germany. It was the product of a long and continuous research chain in the area of synthetic antipyretics and analgetics that had already been initiated in the early 1880s (e.g. Antipyrin® 1884, Pyramidon® 1897, and Novalgin® 1921). At the end of the 1920s the Hoechst scientists had focussed their research on the development of medications with both painkilling and spasmolytic properties (MOLL 1990; HOECHST AG 1992) and a first major progress in research was made in 1937 when the Hoechst chemists Eisleb and Schaumann discovered Pethidin/pethidine (1-methyl-4-phenyl-4-carbaethoxypiperidin), an effective opioid analgesic drug which was launched in Germany in 1939 under the trade name Dolantin® (SCHAUMANN 1952). In the course of ongoing research on synthetic opioids the Hoechst scientists Bockmühl and Ehrhart discovered a number of basically substituted diphenylmethanes acting both analgesically and spasmolytically. One of these compounds was 2-dimethylamino-4,4-diphenylheptanon-(5), which they numbered Va 10820 (BOCKMÜHL/EHRHART 1949; SCHAUMANN 1952). Va 10820 was to become known as methadone no sooner than 1947.

Due to the huge number of compounds discovered in 1939 Ehrhart started pharmacological tests with Va 10820 only in early 1942 (after a lot of other compounds had already been tested). Clinical tests still followed in the autumn of the same year (SCHAUMANN 1952). Compound Va 10820 was also provided to the military, the German Wehrmacht, for additional testing under the code name Amidon (PRESTON 1996). To date, there is no evidence that Amidon was handed over to the Wehrmacht in appreciable quantities. Since at Hoechst the production level of Amidon was very low, the top priority of opioid production lay with Pethidin, only an insignificant quantity could have been handed over to the military. All known sources clearly indicate, that after the first clinical tests had been completed, Amidon was not used during World War II - most likely, both the Hoechst scientists and the Wehrmacht doctors used inadequate doses in the experiments causing undesirable side effects: There is no evidence that Amidon had been used as a painkiller in casualty clearing stations or military hospitals. Further, the drug had not been approved for commercial production. Thus, the civic medical sector had also been excluded from being supplied with Amidon.

For the reasons given above, it is dishonest to state that “methadone” had widely been used during the war as a painkiller and a substitute for morphine under the trade name Dolophin (Dolophine), allegedly derived from Hitler’s first name Adolf. Also, stating that Amidon had been called Adolfin (Adolphine) among soldiers and civilian people is entirely unfounded. In fact, the name Adolphine was created in the US in the early 1970s:

“The invention of the term ‘Adolphine’ by New York City street linguists in the 1970s was an apparent attempt to discredit methadone treatment by those unsympathetic to it, using the Hitler association” (BYRNE 1995, 20; see also KLEBER 2002).

The discovery of Pethidin (pethidine), Amidon and several other synthetic opioid analgesics must not be seen isolated from Hitler’s attempt to achieve in Germany a state of economic and industrial independence of other countries (autarchy), as pronounced in 1936 when Hitler introduced his war-preparatory Four-Year-Plan (KÜHNL 1977; PIEPER 2002). As a consequence of the re-organisation and re-structuring of the German trade and industry there was also a stepping up of efforts to become independent on the import of opium needed for the production of morphine.

Of course, the discovery of medications cannot be ordered by politicians or military forces. Acting together were both intensified research activities within the scope of the Four-Year-Plan as well as decades of research in the field of analgesics. The more financial support and manpower, the more intensive research is possible and the more chances are there to make discoveries.

After the war, all German patents, trade names and research records were requisitioned and expropriated by the allied forces. The records on the research work of the I.G. Farbenkonzern at the Farbwerke Hoechst were confiscated by the U.S. Department of Commerce Intelligence, investigated by a Technical Industrial Committee of the U.S. Department of State and then brought to the US.

It was only in 1947 that Amidon was given the generic name “methadone” by the Council on Pharmacy and Chemistry of the American Medical Association (COUNCIL...1947). Since the patent rights of the I.G. Farbenkonzern and Farbwerke Hoechst were no longer protected each pharmaceutical company interested in the formula could purchase the rights for commercial production of methadone for just one dollar (MOLL 1990). Commercial production was first introduced in 1947 by the US company Eli-Lilly. Only then methadone was given the trade name Dolophine, derived from the Latin dolor (pain) and finis (end). Many companies in other countries soon followed and methadone was given many trade names, some of which still exist: Adanon®, Adolan®, Althose®, Amidone®, AN-148®, Anadon®, Biodone®, Butalgin®, Diskets®, Dolamid®, Dolophine®, Dopridol®, Eptadone®, Heptadon®, Heptalgin®, Heptanal®, Heptanon®, Ketalgin®, Mephenon®, Metasedin®, Methadone®, Methadose®, Methox, Miadone®, Pallidone®, Petalgin®, Phenadone®, Physeptone®, Sedo Rapide®, Symoron®, Tussol®, Westadone® (SCHAUMANN 1952; GERLACH/SCHNEIDER 1994).

As a consequence of post-war events (e.g. the I.G. Farbenindustrie was broken up by the allies) the newly founded Hoechst AG could only in January 1949 launch methadone on the German pharmaceutical market under the protected trade name “Polamidon”. The patent approval of Polamidon was given on February 2, 1953. It took four years to have the patent problems clarified with the relevant US authorities.



Main source of reference:

GERLACH, R.: Methadon: Von der Entdeckung zur Erhaltungsbehandlung – Auflösung einiger „historischer Mythen“. In: Schneider, W./Gerlach, R. (eds.): DrogenLeben. Verlag für Wissenschaft und Bildung. Berlin 2004, 29-53



References given in overview above:

BOCKMÜHL, M./EHRHART, G.: Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen, I. In: Justus Liebigs Annalen der Chemie 1949;561(1):52-85

BYRNE, A.: Methadone in the Treatment of Narcotic Addiction. Tosca Press. Redfern 1995

COUNCIL ON PHARMACY AND CHEMISTRY OF THE AMERICAN MEDICAL ASSOCIATION: Methadon, Generic Term for 6-Dimethylamino-4,4-Diphenyl-3-Heptanone. Report of the Council of Pharmacy and Chemistry. In: Journal of the American Medical Association 1947;134:1483

GERLACH; R./SCHNEIDER; W.: Methadon- und Codeinsubstitution. Verlag für Wissenschaft und Bildung. Berlin 1994

HOECHST AG: Zur Substitutionstherapie mit Methadon in der Behandlung Opiatabhängiger. Frankfurt/M. 1992

KLEBER, H.D.: Methadone: The Drug, the Treatment, the Controversy. In: Musto, D.F. (ed.): One Hundred Years of Heroin. Auburn House. Westport 2002, 149-158

KÜHNL, R.: Der deutsche Faschismus in Quellen und Dokumenten. Pahl-Rugenstein. Köln 19772

MOLL, S.: Strafrechtliche Aspekte der Behandlung Opiatabhängiger mit Methadon und Codein. Peter Lang. Frankfurt/M. 1990

PIEPER, W. (ed): Nazis On Speed. Drogen im 3. Reich. Band I. Werner Pieper & The Grüne Kraft. Löhrbach o.J. (2002)

PRESTON, A.: The Methadone Briefing. ISDD. London 1996

SCHAUMANN, O.: Die neuen synthetischen Analgetika. In: Archiv für experimentelle Pathologie und Pharmazie 1952;216:48-77

© Ralf Gerlach, INDRO e.V., Münster, Germany, September 7, 2004

Citation: Ralf Gerlach: A Brief Overview on the Discovery of Methadone. INDRO e.V. Münster 2004. Web-publication available at www.indro-online.de/discovery.pdf

Reputation Comments on this post:

	great find!
	Thanks for the info.
	excellent find