Combinations - Bupropion and Opioid Interactions?

[fiveleggedrat]

Swim (faintly) remembers reading that opioids have some action on dopamine. Since bupropion is an SDRI, would combining the two have a synergistic effect? That, or any side effects/etc?

Yes, I am aware bupropion is not recreational, but I just could find no mention of these two interacting in medical literature, but my reading points to that they might possibly interact.

Swim theorizes dosages in question would be 100mg-300mg, maximum. No seizures, please

Swim would love some info before being a test monkey for his random, nonsensical ideas.

Thanks!

[wespawloski]

I know SWIY has some bad connotations about SWIM :P

but SWIM has read on erowid and such 1500mg plus of BP was a really intense trip (very scary in SWIM's opinion). 5x dose gave SWIM a cocaine like effect but he never went further.

ANYWAY Opoids act as an endorphin receptor agonist. Meaning the only thing that really happens is your sensations are dulled : WHile on morphine you know the the pain is there but you really could care less (even if your leg is blown off) because the parts of your brain that react arnt affected. Welly does affect your motor sensation through dopa receptors but they have nothing in common.

SWIM theorizes people looking for a double high keep taking welly to get a jump while on opiates and kill themselves.

Also Opoids probably have some affect on your acetylcholine system (the branching between your ANS and your CNS) --- (side note parkinsons diesease is due to not enough dopamine in a certain brain aspect). So the seizing from welly SWIM thinks is from acetylcholine bumping. AC controls your Inhib and and stim of your body, while Nore is also on the stim end. So welly causes your nore level to be soooo high that things go out of control. (well is like a 5:1 Ne).

** FYI black widow spider is dangerous because it agonises your ActylC levels so you get a seize and then when the drug is gone your recs are so gone you cant move and paralyze

BUT with a normal or even 3-4x dose of welly there is ALMOST no chance, clinical trials were done with 600 mg welly over weeks and no one seized. and Opoids dont affect that system directly or to a noticable effect.

But if you are going for bi-recreationality SWim would say dont bother. You will be so relaxed he wont care as much about the dopa effects.

** to put it blunt, SWIM says opoids will ONLY depress your system and give you less chance of seizure than ever :P SWIM's xanax lowers his blood pressure which is really great when SWIM sometimes is careless :/

With that in mind, just do a light check during your peak to make sure your BP is fine and you dont feel psychosis

**** sidenote Wellbutrine is a SNDRI, with more nore and some people are prescribed 600mg a day :P SWIM was trying to get his doc to prescribe a pure SDRI (now wouldnt that have been fun :P)

**** also my appologise, after checking I found its a D:N 2:1. Which would mean you would eve have less chance :P and might get a little more dopamine effects like reward and feeling more actualized - sounds like fun with an opiate but you probably wont feel much from Welly if your a normal user.

P.S. Please report, because SWIM is curious that the possible cognitive benefits of welly may be emanated with the hampering

wespawloski added 22 Minutes and 49 Seconds later...

If you feel a little racey even in your opoid state SWIM would say smoke some dank ASAP or drink ALOT of alcohol to bring down those connections that can lead to serizures

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[fiveleggedrat]

1500mg is an ungodly amount. Swim would not take over 300, maybe 400mg. People have had seizures from snorting 300mg.

Well, Swim tried about 75mg oral ground up, taken in 2 doses over 1 hour to avoid uncomfortable physical stimulation (Swim hates Stims).

Added 10mg hydromorphone rectally. No noticed difference. Swim is irritable, but Swim does not think it's from the bupe. Might try another time with 150mg. Swim won't go past that point.

BUT with a normal or even 3-4x dose of welly there is ALMOST no chance, clinical trials were done with 600 mg welly over weeks and no one seized. and Opoids dont affect that system directly or to a noticable effect.

And people have gone tonic-clonic on less Too risky, and Swim is a bit abnormal when it comes to drug reactions.

but you probably wont feel much from Welly if your a normal user.

Naw, Swim found a few bottles of trial size XR, 150mg and 300mg.

If you feel a little racey even in your opoid state SWIM would say smoke some dank ASAP or drink ALOT of alcohol to bring down those connections that can lead to serizures

Why? Pot would not do anything to help physically. Plus, many people report that bupropion and pot have a nasty mental reaction on the high, usually inducing more paranoia/fear/unpleasant assorted mild side effects, but with pot, even small side effects can appear a lot worse from the high. Also, mixing opioids + alcohol is a very bad idea; too much risk of overdoing the CNS depression, except at very low doses. And it ruins the high, IMO.

I hope you don't think I'm being aggressive or attacking your post; It's just very important here to make sure all info is accurate, including my own. Drug info has to be accurate because often lives are at stake. Swim's a knowledge nut too.

Thanks for answering my Q.

[Alfa]

Originally Posted by wespawloski

1500mg plus of BP was a really intense trip (very scary in SWIM's opinion)...

If you feel a little racey even in your opoid state SWIM would say smoke some dank ASAP or drink ALOT of alcohol to bring down those connections that can lead to serizures

This sounds dangerous to me. Is it?

[wespawloski]

Originally Posted by Alfa

This sounds dangerous to me. Is it?

VERY dangers, SWIM got a cocaine high at about 700. Thats as far as SWIM went, only once. The risk of serzure, though nearly impossible, was something SWIM never wanted to happen to him before college :/

I'm not sure about alcohol, because there is a toxicity in which alcohol can be mostly a stimulant by flooding brain Enough and it will do what xanax, GHB, Barbituates ETC accomplish

But as far as your brain nerro chems go, Opoids should have little or no effect just maybe stimulate or inhibit a few pathways elsewhere in your brain (We can conclude the limbic system gets a boost due to your elated response to the drug :P)

Please do some reseach though, I'm not even sure opoids cros the blood-brain-Barrier in which case it would be harmless

[fiveleggedrat]

Most opioids do cross the BBB.

A few do not, like loperamide and methylnaltrexone.

[Richard_smoker]

Originally Posted by fiveleggedrat

Most opioids do cross the BBB.

A few do not, like loperamide and methylnaltrexone.

the ones that make you FEEL different cross the BB..

otherwise, opiates of other non-central-nervous-system are used for the intended side side effeci (i.e. immodium---side effet: constipation. Nobody want a pill to stop them from shiting with now high. -DICK

[Richard_smoker]

hey, 5th leg...

i think i understand your original question, and i'm afraid the answer to your question(?quest?) is no...unfortunately.

this is based on observations from clinical literature, and not from my own experiences with buproprion (never taken it). as your comments about seizures imply, this drug does give a significant "stimulation" to many users...but don't be fooled. it is still an antidepressant, not unlike an SSRI. It must be taken daily and regularly for desired effects. -DICK

[fiveleggedrat]

Swim gets effects from SxxI's and such when he takes them. For example, SSRI's cause Swim to get nauseous and vomit. Took him a long time to make the actual connection, though.

Yeah, Swim mentions in the post above yours that it did not interact with hydromorphone in an earlier experiment.

If anything, It made him more irritable and moody, and caused him a headache. (about 75mg buproprion broken from an XR tab)

[wespawloski]

SWIM doesnt know the pharmacologicsy bu he would recommend anything in a BP crysis that would drop it. Without knowledge, he would just to depressant/

[Richard_smoker]

yes it's very dangerous and stupid. in theory it would work IF both drugs worked ONLY on the exact same neurons. not likely in this situation.

in the situation where someone is already seizing, then you can usually bring them down with a VERY broad-acting benzo. usually start with ativan, then valium, then after escalating doses of both drugs without breaking the seizure, you might have to give some barbituates, then an all-out intubated state of anesthesia with generous use of paralytics.

i've never heard of someone trying to reduce the seizure threshold of an excitatory drug by taking a CNS depressant BEFORE the seizure starts. -DICK