Pharmacology - That's How The Light Gets In: The 5-HT Receptor--LSD connection

[Songcycle67]

I did a search for a topic specifically detailing the relationship between LSD (specifically) and the 5-HT receptors but could only find vague articles. If I've mistakenly overlooked a similar thread please delete this one.

I'm posting this thread because there have been a lot of questions regarding tolerance and receptor sites recently and hopefully this will help to pool all that info. Additionally I believe that general information on this subject could help to answer a plethora of other questions. Please post, in as simple terms as possible, any information detailing how the 5-HT receptors respond to the presence of LSD in the brain.

I know there are plenty of SWIMmers out there who are more familiar with neuroscience than I and could help to shed light on this oft misunderstood/neglected subject, so I'll leave it to you all. Articles and excerpts from noted figures on this subject would be greatly appreciated. I also realize that there is a relatively small amount of data available on this subject, but hopefully through discussion we can refine the data that is available.

I suppose the best place to begin would be: very generally, what is the function of the 5-HT's and what is the going logic as to how LSD binding to these receptors engenders the psychedelic experience?


Edit: edited for clarification. Can some modest moderator please update the thread title to reflect this change? It should read "5-HT--LSD connection" instead of "5-HTP--LSD connection." Thanks shampoo.