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#1
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Sublingual Hydromorphone
Is Sublingual Hydromorphone possible? I'm finding conflicting information regarding this.
Any experiences/information? Making this a thread so it can be archived and found easily through the search engine. |
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#2
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Re: Sublingual Hydromorphone
I know swim wouldn't mind seeing if it is...
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#3
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Re: Sublingual Hydromorphone
Lipophilic drugs are absorbed very readily through mucous membranes such as under the tongue, inside of cheeks, and hydrophilic drugs are not. Unfortunately, hydromorphone is a hydrophilic substance so it has poor sublingual bioavailablity. And poor oral bioavailability. Golden rule of taking hydromorphone is for SWIM to shoot it, or for SWIM to give it to an imaginary friend who does shoot it.
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#4
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Re: Sublingual Hydromorphone
Ahh, I see. Thank you! Here's a little bit of info Swim found when trying to make sense of what you said. I didn't get it right away
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I'm asking all this because I'm doing research on alternative modes of use for it. Swim does not use needles, and know the oral for this stuff is a joke. He also knows rectal does not work well for him, and snorting is not preferred. So far, smoking the pill ground up was a fail. Swim isn't able to extract the little bit he has and smoke it pure either. |
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#5
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Re: Sublingual Hydromorphone
Eddie doesn't do needles, he found (for him) the only useful route of administration for hydromorphone to be intranasal.
I'm positive that some web searching will produce bioavaliability data for all different ROA for hydromorphone. *edit* found this, cannot verify the source however: intranasal- 52.4%, Rectal administration 33% ,Oral-30-35% Last edited by radiometer; 04-10-2008 at 00:46. |
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#6
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Re: Sublingual Hydromorphone
Hello 5leggedRat.......Yes it comes in a oral form but swim sees oral morphine much more often.And although I don't know the oral bioavailabilty this second(ahhh see above)........you can take Dilaudid sublingualy to bypass(to bloodstream before) the liver.But everyswim seems to like to bang the stuff in their arm.....unfortunently it only has a half-life of 2.3 hours by shot...Swim thinks.....but you people know all this
Last edited by thebige; 04-10-2008 at 01:48. |
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#7
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Re: Sublingual Hydromorphone
The only reason I ask all the time about methods and bioavailibility is that the chart here is FAR off for Swim, and is almost ALWAYS. Swim's a different cat, for sure.
One day, Swim will post a chart that applies to him so others can see how different it is for Swim. Thank you all for contributing! Swim will likely not attempt this method anytime soon unless he finds a large supply. Too good to waste. |
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#8
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Re: Sublingual Hydromorphone
Swim can confirm swiyradiometer bioavailability= oral 30-35%,intranasal 52-58%.
swim has no figs for sublingual but it is much higher than oral due to the old first pass thingy-ma-jig. Sublingual hydromorphone=There is a liquid formulation that is commonly available and RECOMMENDED specifically for this route,All tablets(EX-SR!!!!) can potentially be used in this fashion,although they will dissolve more slowly than purpose made "subligual tablets",Swim could remove coating first by scrapeing or sucking first.. |
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#9
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Re: Sublingual Hydromorphone
Thanks for the info. Swim will attempt sub-l or buccal or similar in the next month for sure.
For Swim, 20mg oral = 4mg intranasal. For sure. More euphoria orally, but more sedation intranasal. That is DEF a bigger change than going from 30% to 50%. Also, rectal for Swim was about equal with intranasal. |
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#10
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Re: Sublingual Hydromorphone
Quote:
Also has swiy considerd "nose drops" as an alternative to snorting?? |
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#11
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Re: Sublingual Hydromorphone
Swim has done the carbonated thing with oral, and also with GFJ and various other things. No difference for Swim, it was the same thing.
Nose drops meaning snorting liquid solution or using one of those little squeeze bottles for the nose? Swims done liquid snorting before and it did not work, but not the other one. Lastly, Swim is interested in trying opioids with a nebulizer once put in a liquid solution. Just thought I'd mention. |
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#12
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Re: Sublingual Hydromorphone
Swim tells me that Nose drops=prepare as if injecting then use pipete or simillar/srynge minus needle....Drop liquid into nose and allow to run down inside the inner nostrils,swiy may want to try a dry run with water,also use as little water as poss for actual drug/run(don't want to be pouring 10ml liguid down your nose!!!?
There are nasal sprays on the market so nebulizer will work very well... |
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#13
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Re: Sublingual Hydromorphone
jon-g, could Swim take a ground up pill in water and use that in a nebulizer? Can you at least speculate? Swim has one and used to use as a asthmatic as a child.
Swim snorted liquid hydromorphone that he prepared for something, he does not remember, but he fucked it up so he had a plate of water + 4mg hydromorphone. Did not really get much, if anything out if it, especially compared to plain snorting. |
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#14
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Re: Sublingual Hydromorphone
Quote:
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