Experiences - Unafected by morphine?

[youdontknow]

So the other day swims friend gave him eight 30 mg instant realease morphine sulfate pills. SWIM had done morphine before, a hundred mg er tab. With his past experiences swim had never really been affected by it. He figured since ther were IR then maybe they would. SWIM busted down 2 of them and put them up his nose and then chewed up the third one. After about an hour he really didnt feel the usual euphoric feelin of opiates. He really just felt kind of wierd, definately not enjoyable. He wouldnt compare it to any other kind of opiate aqnd doesnt like it. Its wierd because he LOVES h and was under the impression that morphine and h were the same thing once they hit your brain.

I dont know, any suggestions on dosage or something to make it better?

SWIM has a tolerance and does about a quarter gram of raw at a time or an 80mg oc at a time

[fiveleggedrat]

80mg oxycodone is quite a bit. So is 1/4 gram H. It's possible 1) You just dont like morphine. All opioids are different or 2) You have too high of a tolerance.

Morphine and H are different, but Swim always gets confused explaining and manages to fuck up the explanation. Use the search engine here, we have TONS of information.

[TheNewLeft]

ive actually heard this from a variety of people. that morphine, unless its IV'd isnt nearly as strong as the other opiates (hydro, oxy, etc)

[chillinwill]

here's a thing from wikipedia about heroin breaks down

When taken orally, heroin undergoes extensive first-pass metabolism via deacetylation, making it a prodrug for the systemic delivery of morphine.[3] When the drug is injected, however, it avoids this first-pass effect, very rapidly crossing the blood-brain barrier due to the presence of the acetyl groups, which render it much more lipid-soluble than morphine itself.[4] Once in the brain, it is deacetylated into 3- and 6-monoacetylmorphine and morphine which bind to μ-opioid receptors, resulting in intense euphoria, decreased pain perception and anxiolytic effects (relief of anxiety).

Oxycontin is the trade name for time-release oxycodone. Oxycodone, morphine, and heroin are formed from a similar chemical "backbone", with slightly different atoms on certain parts of this backbone. However, oxycodone and heroin are more different structurally than morphine and heroin, SWIM believes. Heroin has 2 acetyl groups on either end of the molecule which increase its ability to get into the brain more efficiently, thus accounting for its strength. It may cross quicker than morphine, but it certainly crosses more efficiently, milligram for milligram.

Oxycodone and morphine probably dont "pass into the brain" at drastically different rates, and actually they are of equal potency in most dosage equivalance charts. HOWEVER they have different bioavailabilities, and are only subjectively equal when administered IV. Oxycodone absorbs through the stomach into the blood much more efficiently than morphine, run a search on bioavailabilities to see what I mean. So orally, oxycodone absorbs maybe 8-10 times more efficiently than morphine, meaning 20 mg oxycodone would feel much stronger than 20 mg morphine if a SWIM tried them at different times.

Heroin doesnt absorb that well orally, SWIM hears, but if compared to morphine and oxycodone strengths in terms of IV routes, heroin has at least twice the potency of oxycodone or heroin.

[fiveleggedrat]

I do agree that morphine based drugs tend to have what seems like fewer desired effects for dosages. As Swim's mental tolerance goes up, this becomes more apparent. He has to pretty much suffocate from hydromorphone intranasal before he gets where he wants, whereas with oral oxy/hydrocodone, Swim's where he wants to be with much less sedation and excessive dosing.

Morphine family drugs tend to be more finicky in terms of effects, I think.

IV morphine family drugs probably are way better than non-IV. Swim would not know, he refuses needle use for a few years at least.

[beena]

Morphine is definately a milder buzz compared to heroin. SWIM built up a tolerance to morphine fairly quickly too and at the very least she would have to have ten 30mg morphine sulfate tablets to get any reasonable high. Her usual dose would be twenty (600mg morphine). Since she started taking heroin though the only thing morphine seems to do for SWIM is stave off the withdrawals and cravings. SWIM took 900mg of morphine a while back a couple of days after taking heroin and it did nothing for her at all. The thing is she was probably pretty out of it in reality - she just didn't feel thathigh.