Pharmacology - Cannabis pharmacology.

[Felix Guattari]

I'm almost certain there has been data on this posted on the forum somewhere, but none of my searches came up with anything substantial.

Does anyone have any articles that give a complete picture of the method of action of cannabis? I know its particularly tricky, seeing as there are a whole slew of actives, so I suppose it might be useful to focus in on the two most often studied, delta-9 thc and cannabidiol.

What I've been able to piece together is that activation of CB1 and/or 2, by 'mimicking' anandamide and other endogenous cannabinoids, triggers release of phenylethylamine, which acts on (at least) TAAR1, thereby increasing dopamine, nor-e. and serotonin. Of course, I know there's more going on here.

I know this is a topic of pretty titanic proportions, but I thought it would be cool to get a thread going to try to compile what's known on the subject of cannabinoid pharmacology, perhaps for stickying purposes, as I feel this information ought to be easier to find than it is (unless, of course, I'm just a terrible researcher, in which case, just tell me to shut up and point me to where I can best get something answerish).