Pharmacology - Possible strong opioid potentiator

[RoboCodeine7610]

SWIM found this in another forum:

Nigella sativa seed has opioid action. in a laboratory the seed oil suppressed nociceptive response in the hot-plate test, tail-pinch test, acetic acid-induced writhing test and in the early phase of the formalin test in rats. the activity as blocked by narcan.

yes, nigella sativa seed oil is REVERSIBLE BY NARCAN!!! very important.

the seed oil is cross tolerant with morphine, but apparently not the other way around.

the polyphenols have some analgesic activity, but it is still poorly understood. most likely the analgesia from the polyphenols is not from activity on the opioid receptor sites. the opioid activity comes from thymoquinone.

last night I took the seed oil for the first time. ingested a bit more than a tablespoon. about 30-45 min after eating the oil, my stomach was in very minor discomfort and I was experiencing opioid effects similar to kratom, but less complex. the addition of a tea made of three lanced and partly dried poppy pod was made. a tea of three unlanced pods from the plants I grew(remember alk content will vary in poppy pod) is usually a bit short of a full nod. with the seed oil, I used a much lower dose(taking into consideration the pods were lanced and much morphine was lost to collecting opium), and achieved a round trip ticket to nodland.

all in all, THIS STUFF IS GOOD! pretty easy to find, and works wonders as an opiate augmentation. I will give more reports of my use of the seed oil as an intoxicant on its own and as augmentation for oxycontin and kratom

Links:
http://www.liebertonline.com/doi/abs...jmf.2005.8.488

http://www.saudijgastro.com/article.asp?is...06;aulast=Tariq

http://www.drugs.com/npp/kalanji.html

http://www.eprints.hec.gov.pk/1813/1/1742.htm

commonly known as Black cumin it is said to greatly potentiate the effects of opioids,Does anybody know about this?Anybody tried this before?

[fiveleggedrat]

Swim knows his next project...

[jon-q]

Very interesting,is (nigella sativa seed oil)a controlled drug/product.

[fiveleggedrat]

Swim perused Google with Nigella Sativa.

Indeed, it is known to have agonist effect on opioid receptors.

However, from Swim's limited knowledge, it appears it will also have a good amount of other peripheral negative effects. EG, this might be a loperamide, so to speak.

Question, OP: Do you believe this is/has potential for a sole recreational substance or as a potentiator only? Sorry if that seems dumb, but wondering your thoughts.

fiveleggedrat added 1 Minutes and 58 Seconds later...

Check this out:

Lab analysis show that Black Seed oil contains the following Essential Fatty Acids: Myristic Acid(0.5%), Palmitic Acid (13.7%), Palmitoleic Acid (0.1%), Stearic Acid (2.6%), Oleic Acid (23.7%), Linoleic Acid [Omega-6] (57.9%), Linolenic Acid [Omega-3] (0.2%), Arachidic Acid (1.3%) - and the following nutrient components Protein, Thiamin, Riboflavin, Pyridoxine, Niacin, Folacin, Calcium, Iron, Copper, Zinc, Phosphorus.

[cuddlesthefox]

Is it a cookery ingredient? Is Nigella Lawson involved in any way? Do they sell it in Asda?
Will it work with Dihydrocodeine?
This is going to take some investigation.

[RoboCodeine7610]

Okay, if it does work, which from the information swim has gathered he thinks so, it would work with any opioid, and yes, with dihydrocodeine too.
It IS used for cooking and can be mostly found at Lebanese markets.
SWIM guesses there might be some at the supermarket but he's not sure.
Any input about this would be greatly appreciated.
I forgot to add, you can of course find some at a herbal store.

RoboCodeine7610 added 5 Minutes and 53 Seconds later...

Yesterday swim found out that some people claimed that the seeds had an opiate effect by themselves so swim tried a couple and had some really weird effects, like not being able to wipe a smile off his face.
Anyway swim could not sleep in like 26 hours and had not slept for a long time before injesting the seeds so he's not sure if it was the seeds.
So he injested a LOT MORE seeds about 10 minutes ago and will report back.

RoboCodeine7610 added 55 Minutes and 21 Seconds later...

+15 Okay swim feels REALLY weird but he doesn't think it's an opioid buzz. Unfortunately, SWIM's experience with opioids is limited to codeine so he could be wrong.

+20 SWIM is pretty sure they're vasoconstricting, because swim's hands and feet feel extremely cold.Swim thinks he might be feeling some euphoria but he thinks it's just placebo.

+23 Swim feels some kind of temperature change all over his body, but he's not sure if it's hot or cold or a mix of both.
he knows it sound very weird but it's just really hard to explain what he's feeling.
Swim's hands and feet are like they're FREEZING right know and he feels something weird inside his nose, like bleeding but he's not sure.

+30 Swim has a headache, but not a regular headache, just more of a hypertension head ache, like his blood pressure is skyrocketed.

+37 Swim check his pulse and it's 86.Unfortunately, he can't check his blood pressure because he has no bp machine to do so.At this point, swim is pretty sure that they have no opioid effect.

+45 Swim's hand and feet don't feel cold anymore.Swim's headache is getting worse, and swims blood pressure is still high.Now he feels really lethargic.He has a weird feeling all over his body, but hes not hot/cold anymore.

+55 The weird feeling all over his body is almost gone and he feels close to normal at this point.
Next time swim will try to take less and combine it with codeine and see if there's any potentiation.
Swim is sure, however, that the seeds have no opioid effect by themselves, and that they should be taken with care since they seem dangerous at high dosages.

[OhCasey]

Its commonly sold as Black Seed Oil and is considered a cure all by many cultures from Africa/Middle East to India and China. Its more of a medicinal supplement than a cooking oil. From what Ive read it doesnt work in seed form but only in cold pressed oil form. The effects arent fully understood but there isnt any known negative effects from what I could gather most of the stuff present in the oil is just essential fatty oils. It seems like it may be a opiate potentiator but not an extremely strong one. It wouldnt be similar to lopermide since we all know lopermide doesnt cross the BBB (not without some serious equipment, dedication and guts anyways). Experiences Ive read have stated that it gives a small sense of euphoria at doses as small as 1 teaspoon. It doesnt seem like a great opiate potentiator but Ive read a report of increased nodding when taken with Oxycodone but hey everyones different. What interests me about this oil is that it seems like it would be perfect for opiate withdrawal when even a little relief can seem like a life saver. The most promising use could be in the week or weeks after opiate use where it might provide a little mood elevation or atleast help with the post withdrawal effects similar to L-tyrosine maybe.

[RoboCodeine7610]

Yeah, that's right.The muslim prophet mohammed said it was a cure for all diseases except for death.Personally I wouldn't go as far as saying it's a cure to every disease but I do believe that it does have some medical value. About the no known negative effects, just read the above post it really does have some really naughty side effects when consumed in excess.

[OhCasey]

Those negative effects swiy experienced might be related to the consumption of seeds rather than the oil. From what I've read the oil is active at amounts far lower than what would need to be ingested in seed form. Reports I have come across actually dont suggest ingesting the plain seeds.

[RoboCodeine7610]

Those negative effects swiy experienced might be related to the consumption of seeds rather than the oil. From what I've read the oil is active at amounts far lower than what would need to be ingested in seed form. Reports I have come across actually dont suggest ingesting the plain seeds.

The oil is pressed out of the seeds by chewing them before swallowing which is how the seeds were consumed.

[OhCasey]

Originally Posted by RoboCodeine7610

The oil is pressed out of the seeds by chewing them before swallowing which is how the seeds were consumed.

Yeah I wouldnt reccomend taking that route especially when the cold pressed oil is very available.