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  #1  
Old 07-09-2008, 01:53
stephy171072 stephy171072 is offline
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Amitriptyline

SWIM has 7 10mg Amitriptyline pills and wants to use them to get to sleep and she has heard that they are good for helping that. Does anyone know how much SWIM should take? SWIM has taken a few before but only once and has a high tolarance to a lot of other sleeping pills, so much that they don't work anymore. SWIM is just desperate to get some sleep but not so much that she wants to OD lol. Thanks in advance x
  #2  
Old 15-09-2008, 06:35
Jatelka Jatelka is offline
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Re: Amitriptyline

Amitryptiline is occasionally used at doses of 25mg or so for sleep.

Be warned though, even at this dose anti-cholinergic side-effects can be a problem: Dry mouth, blurred vision, urinary retention, all can interfere with getting off to sleep
  #3  
Old 18-12-2008, 15:49
-Kurt -Kurt is offline
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Re: Amitriptyline

it's good to take amitriptyline RIGHT before bed. take your dosage and hit the sack, and hopefully SWIY will be sound asleep by the time the 'recreational' side effects of amitriptyline rear their head. beware though, itll be very hard to get up in the morning, and youll feel exceptionally fuzzy for an hour or two when you wake up.
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Old 31-12-2008, 22:54
scottaaaay scottaaaay is offline
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Re: Amitriptyline

experience tells one to take 3 and that should do the trick, wait 20 mins and you should start to feel abit sluggish, so hit the sack!
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Old 01-01-2009, 13:38
Slayerkorn Slayerkorn is offline
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Re: Amitriptyline

I was also prescribed Amitriptyline to help me go to sleep. I really didn't like it. It basically knocked me out cold for about 24 hrs, the sleep I got didn't feel restful at all. My dose was 25mg.
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Old 04-01-2009, 20:38
Panic_Upset Panic_Upset is offline
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Re: Amitriptyline

Amitriptyline is one of the first tricyclic antidepressants that is often scripted as a sleep aid in small doses of 35 mg or less. As far as depression goes it can be prescribed in higher doses but I would not recommend attempting to take more than 70 mg. Depending on your tolerance, Amitriptyline can cause your heart to go into a irregular rhythm known as Ventricular Fibrillation (V. Fib.). This will lead to Cardiac Arrest (FUCKING DEAD) if not treated immediately by strong Cardiac Drugs like Vasopressin, Epinephrine, Amiodarone, and Lidocaine. THIS IS VERY FUCKING SERIOUS! Anyways, I have been previously prescribed 30 mg (3-10mg tabs) of Amitriptyline as a sleep aid and as others stated above it can be very difficult to rise in the morning. Many people report after the use of Amitriptyline as a sleep aid and/or antidepressant that they experience what is called "Zombification". Its common and it sucks ass. Anyways, hope SWIY gets some sleep!
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Old 17-01-2009, 03:18
stephy171072 stephy171072 is offline
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Re: Amitriptyline

Swim thanks everyone for replying on this thread. Swim didn't really find the Amitriptyline very helpfull for sleep and now takes temazepam which swim likes a lot more! Swims doctor has now taken her off the amitriptyline however as swim was just having a really hard time and took a few too many of them and ended up in hospital.
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Old 01-02-2009, 03:43
Synesthesiac Synesthesiac is offline
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Re: Amitriptyline

Quote:
Originally Posted by Panic_Upset View Post
as others stated above it can be very difficult to rise in the morning. Many people report after the use of Amitriptyline as a sleep aid and/or antidepressant that they experience what is called "Zombification". Its common and it sucks ass. Anyways, hope SWIY gets some sleep!
Swim gets this. He was prescribed some to help combat very odd sleep paralysis and brain zaps after using too much MDMA. He started at 10mg a night, which did nothing, 20mg was marginal effects, and 30mg knocked swim out and gave him a dry mouth and blurry vision. It is impossible to get up the day after, you want to just stay lying in bed all day and it made swim feel really tired, warm and fuzzy, which, actually, was a very nice feeling! But not very practical when your supposed to be going to work Swims got about 200 10mg tabs left now and he doesn't know what to do with them, he'll probably use them when he's got a lazy day to be had to chill him out.

Its certainly a conscious clouding drug though, what swim would consider a 'dirty' drug. The opposite of a nootropic.

However swim surprisingly quite likes the 'zombification', but not when he has things to do.
  #9  
Old 15-07-2009, 13:18
zulu1690 zulu1690 is offline
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Re: Amitriptyline

swiysynesthesiac is the first person swim has found that has suffered sleep paralysis and brain zaps if swiy means by brain zaps a feeling like cramp in the brain that causes the paralysis.but swim gets these effects when swim runs out of amitriptyline.swim is prescribed 200mg a day which is 4x50mg .swi stephy171072 be careful as swim has od'd on them aswell and first time was in a coma for a week and another time swims heart stopped.swim would urge all swimmers to be careful with amitriptyline.
  #10  
Old 23-10-2009, 07:30
JCJC JCJC is offline
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Re: Amitriptyline

10mg knocks swim right out and he has a great sleep.

for swim more than 20mg means he sleeps for ages and has a hard time waking up.
  #11  
Old 24-11-2009, 02:30
anonuser30500 anonuser30500 is offline
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Re: Amitriptyline

Damn, Swim got these prescribed for back pain but upon reading the few posts here he wonders why he has to take them before sleep. After all, lying down for bed usually eases a bad back. Swim problem is not sleep, just back pain.

I have a 20mg prescription but am looking at the two tiny tablets and don't think I fancy waking up sluggish, or having blurred vision.
  #12  
Old 30-11-2009, 01:35
Panic_Upset Panic_Upset is offline
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Re: Amitriptyline

Amitriptyline is prescribed for pain due to the affect that its suppose to affect the way you perceive your pain tolerance

-Jupiter Out
  #13  
Old 02-01-2010, 02:47
Laudaphun Gold member Laudaphun is offline
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Re: Amitriptyline

Amitriptyline can intensify and prolong the effects of analgesics, as well as having a therapeutic/lethal dose ratio as low as 5 or less. So, definitely a pill not to be too careless with dosing. SWIM finds it to be an extremely useful medication to keep on hand, and it seems to work at relatively small doses in comparison with the dosing that some of SWIM's books suggest. Primarily metabolized into nortriptyline which is used for smoking cessation (SWIM discovered this accidently, and spent 2 weeks trying to figure out why she no longer had any desire to smoke).

Useful in some fairly serious illnesses where depression, and insomnia are accompanied by lack of appetite. Definitely go with the "less is more" attitude on this one.
  #14  
Old 14-01-2010, 00:53
Retinoidreceptor Retinoidreceptor is offline
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Re: Amitriptyline

SWIM took about 70mg of Amitriptyline the first time and woke up the day after the next day with extreme dry mouth and his eyes were all black like he painted black eye shadow around his eyes due to severe dehydration and his tongue was coated extremely white due to dehydration and he thought it was the morning on the previous day. He figured since it is an antidepressant it couldn't be that strong. But Amitriptylines are pretty hard and will make you sleep or want to sleep for a whole day rather than just one night. Ask your doctor for Ambien, it is superior. Makes SWIM hallucinate if he takes it on an empty stomach, but puts him to sleep and he wakes up fine the next day.
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Old 18-01-2010, 15:44
Laudaphun Gold member Laudaphun is offline
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Re: Amitriptyline

The therapeutic to lethal dose ratio can be as low as 5.0 in some people for TCAs. Amitriptyline is in particular dangerous. a 70mg dose is not real safe for someone who has never taken the substance before... others have actually ended up in comas from, "my marmoset thinks" actual therapeutic doses and woke up in the hospitol and wondered what the $#)%$?

Barbiturates have a greater safety margin than TCA. Amitriptyline is metabolized into nortryptriptyne which is considered toxic. Or at least to a certain extent when it is metabolized. SWIM's marmoset forgets the literature that listed the safety indexes, but barbiturates were 10.0 on average and amitriptyline fell into the "under 5.0 category" But, everyone's body is different so that is obviously an approximation and YMMV.

TCAs are far more effective in SWIM's case than any of the SSRIs or SNRIs... but the only other reason they seem to being phased out other than increased safety risk, is ISHO greedy pharma companies... TCAs are old, cheap, dangerous, but very effective in certain individuals.

The problem is that depressed individuals tend to be more likely to be suicidal and as Tricyclics are (from what SWIM has read) rather difficult to treat in an overdose they are not indicated for a patient who is has suicidal tendancies. But, TCAs in overdoses also can cause seizures and other unpleasant symptoms, not to mention death....

I think it has been mentioned by others, they can also put people at risk for increased complications with other meds. Please be careful with this one... it's pharmacologic profile is actually very interesting as it has side-effects that can actually be useful, such as increased appetite, and sedation when an illness or depression itself is causing loss of appetite and insomnia... Hepatitis C perhaps an example of such an illness, the drugs used to treat it cause these symptoms, just as with chemo patients. So, in SWIM's opinion they are far from obselete, but must be treated with respect. OH and an accidental discovery by SWIM was as she mentioned below she just lost the desire to smoke after taking it, but she couldn't figure out why. Hell, it was really bugging SWIM so after 2 weeks of digging through books it suddenly was obvious as nortyptyline is it's major mebabolite as I described below. Not to be repeating myself but, this really caused SWIM to become quite intrigued in this drug after realizing it was not FDA approved for smoking cessation, but it's metabolite was. It took her 2 weeks to figure this out, and felt rather silly when she realized that she had known the answer the whole time, just not bothered to take a few seconds to put the mystery together.

SWIM has not smoked a cigarette since, and never intended to quit. It worked when SWIM had no desire to discontinue smoking. SWIM is glad to have quit now, but was confused as hell til putting that together. The stuff was only taken for a brief period of time and still there is no desire to smoke a cigarette... This is something SWIM was excited about and wanted to do some research on and write up a paper, but alas life has been making it rather difficult lately to complete any compilations.

SWIM would be interested to here about more people who have had experience using that drug. Imipramine was and still is "SWIM thinks, 99%" sure is the golden standard for TCAs and was not as helpful in SWIM's case as Amitriptyline... Errr actually Imipramine was the prototype for all TCAs that followed. In the 1960's perhaps it was first marketed??? Amitriptyline was not marketed in the US until 1983, shortly before the TCAs were considered by many to be obsolete as the SSRIs and SNRIs were introduced into the market.

Please be careful with this, or any other TCA as they are not very forgiving if someone were to attempt misuse them. Fortunately, SWIM has never had to experience this as some other posters have.

-Laud
  #16  
Old 05-03-2014, 09:10
kzoejones kzoejones is offline
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Re: Amitriptyline

Wow! Hubby was prescribed Amitriptyline for a leg injury. On his box of Endep 25mg, it says "Take 1-6 at night"!!! He was taking one a night but discontinued use after about two weeks, complaining of feeling groggy and 'not right'. Although, I have also read about some great recreational value in them. What do u think?

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amitriptyline, drug, drugs, drugs-forum, insomnia, kratom, opiates, overdose, prescription drugs, recreational use, sleep aid, sleep paralysis, sleeping pills, sleeping tablets, smoking cessation, therapeutic dose, tricyclic, tricyclic antidepressant, tricyclics

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