Here's the deal w/ buprenorphine
: Bupren. is very strong at "Grabbing" swiY opiate
receptors and holding on/standing guard. Once on the receptor, bupren. will NOT allow any other opiate onto the receptor. The problem is, although they are strong in this sense, they are NOT strong enough in the 'Getting High' sense.
So, for example: Someone is on a large dose of H (and a daily user)....they take some subutex
/suboxone/etc. The Buprenorphine goes in......kicks the H off the receptors....and takes control. Problem: Now the user gets SICK!....as the Bupren. dosn't fulfill the users need.
Naloxone: Typically used in Opiate Overdose, life/death situations
Naltrexone: Typically used to treat dependence, daily dose, etc.
Although it is Naloxone that is in some forumulations of Buprenorphine (Suboxone
). This 'Blocker' was originally put in, not to stop the use of "Other" opiates
, but rather attempt to stop the abuse of the Buprenorphine itself. The effectivness of this is up for debate.
Bottomline is, a heavy Opiate user/abuser even after some abstinance will probably find very little "Pleasure" from doses of Bupren., other than what 'pleasure' they receive from not being in withdrawl..lol....
PS: SwiS realizes this is highly oversimplified (mostly for swiHis own understanding..lol)...That being said, the Wikipedia has some very nice, well referenced, highly detailed articles covering all of the above (Buprenorphine, Naltrexone, Naloxone, etc.)