Tolerance - Every SWIY's highest tolerance achieved/opioid(s) implemented?

[TAz69x]

We've all been there... reaching a level of tolerance either due to a ridiculously good supply or through (as SWIM has done in the past on two occasions, which account for both "tolerance ceilings" for SWIM) testing for personal experience and research into the effects and analysis of high tolerance, doses, etc.

SWIM uses opioids to treat depression, in combination with heavy research.
This has lead to two occasions (taped on film as well) to test tolerance levels and effects thereof.

Morphine Sulfate: 750mg intramuscular daily (reduced to 25mg daily in JUST THREE WEEKS, with a HUGE SUPPLY of Duragesic 7.5mg patches remaining (>700 patches)), which, as all of us SWIM's know, requires an immense source of willpower and drive, both of which aren't difficult, though shows how strongly will and drive are when researching/using opioids properly (in this case for treating depression and occasional recreation).
This beautifully highlights the ability of the intelligent to use willpower and intelligence to utilize opioids properly, and quit through will alone without coercion of any kind.

Fentanyl: 52.5mg orally at one time (gastrointestinal absorption, not buccal).

Both warranted obviously little effectual mu-2 euphoria agonition, but were amazing sources of research to test the effects and ability of tolerance and pharmacological effects at increased tolerance doses.
At this level, a "ceiling" is reached whereby kappa effects dominate, and a level of (stupor is improper, but "tiredness" better describes it) is dominant.

Both research instances were short lived, and were an INVALUABLE source of information to learn first-hand the invalidity of approaching increasing tolerance levels, and the benefit of proper moderation (need not be too strict, just proper) and observation of one's own doses to effect proper supply-maintenance and effects dually.

Anyways, this main thread was just for interest! No need to delve too heavily; always interesting for all us SWIM's to know. Experiencial information is greatly welcomed too if you want! Though minimal replies are just as informative.

Reputation Comments on this post:

Good topic. Well written too.

[fiveleggedrat]

Swim sadly has nothing useful to contribute here =[

This Swimmer has no experience with physical tolerance, only mental.

He went from nodding on 100mg tramadol to barely getting a buzz from 300mg. Also, 20mg hydrocodone used to be enough to almost nod. Now, it takes minimum 70mg, usually around 100mg, to reach a good point.

Swim is sure other's numbers are x10 his own

Swim also hit a full 20 bag of heroin up his nose (estimated around 100mg, brown type, it was for sure H but unsure of purity. tasted like H!) and did not get much else, not even close to nodding. Underwhelming experience, for sure. Swim wishes the stupid dealer would have just sold him a gram, like he asked for. It Swim's area, the dealers will not go above what they call a 40 bag, which should be in the range of 200-400mg, depending on the dealer. All they care about is profit.

Not discussing prices, only terms/slang and numerical amounts.

Swim likes this topic, others should contribute

Interesting to see how far some have pushed the limits of opioid tolerance.

[tryptamaster]

swim is new to opiods but went from 10mg oc giving him a very nice high to getting a low level buzz from 20mg oc. this may not seem like a big deal to many swimmers but for swim this was a significant increase.

[fiveleggedrat]

Swim feels you on the above there. Best times ever for opioids is when you first do em.

Shit, any drug

[TheNewLeft]

swim used to get a kick-ass buzz from 15mg of oxycodone or 20mg of hydro...or even 150mg of codeine.

now....swim needs 50mg of oxy or 75mg of hydro to get a buzz and codeine is useless at any dose

[fiveleggedrat]

Someone needs to discover how to reverse mental tolerance! Boo!

[nleksan]

SWIM's highest tolerance achieved was when he was "friends" with a pharmaceutical distributor. He was able to purchase the pharmacy-bottles at wholesale prices.
In a typical week he would order:
- (2) 100ct Opana IR 10mg
- (1) 100ct Opana ER 40mg
- (1) 100ct Oxycontin 80mg
- (1) 100ct Hydrocodone/APAP 10/325mg
- (2) 100ct Oxycodone HCl 30mg
- (1) 200ct Hydromorphone 4mg
Total = $395.67
Occasionally he would add:
- (1) 100ct Morphine ER 200mg
- (1) 200ct Morphine IR 30mg
- (1) 1L-bottle Roxanal 20mg/mL (Morphine Sulfate liquid)
- (1) 25ct Duragesic (Fentanyl) Patches 100mcg/hr
Total = $572.38

He would typically start the day with 10mg Opana and 8mg Hydromorphone injected intravenously in one shot. He would also take 40-70mg Oxycodone/APAP and 80-160mg Oxycontin orally. He would crush 20mg Opana ER (1/2 pill) and mix with 40-80mg Oxycontin (crushed) and insufflate. This would keep him going until lunch.

At lunch he would consume 50-100mg Hydrocodone/APAP orally, 20mg Opana ER insufflated, and 30-50mg Oxycodone/APAP orally.

When he got home from work, he would do his "Big Shot" for the day, which was either a high dose of Opana, Dilaudid, Morphine, or a combination thereof. It typically focused on the Opana, and he would do a first-shot of 25-40mg. This required multiple filtrations in order to get all of the "goods" in one 1mL rig. This would keep him high for 2-4hrs, and then he would do a second shot, which was usually one of the following:
- 10-20mg Opana AND 12-24mg Dilaudid
- 15mg Dilaudid AND 200mg Morphine Sulfate
- 1.5-4mg Fentanyl AND 5-15mg Opana
- (Many other combinations were tried...)

So, using equivalency charts, SWIM's tolerance was around 2000-3000mg oral Oxycodone/day. SWIM ordered the Fentanyl patches so that he could have something to keep him "well" if he were to run out of the goods in-between orders. He would have to slap-on 2-3 patches at once in order to recieve effects; 5 patches would keep him nodding in and out for 36 hours.

Luckily, SWIM no longer has the monstrous tolerance that he developed. However, HE DOES NOT EVER RECOMMEND getting that far into the rabbit-hole. Withdrawals were so bad that he thought he was dying. Opana is NO JOKE when it comes to raising your tolerance. When he started, 3mg IV would have him FLOORED (already tolerant to 8-10mg Dilaudid IV). 4 months later, it took 45mg IV Opana to get the same rush.

[static_vodka_420]

400 mg oxycodone

1 gram tramDOL


30 methadone 10s

5 oxymorphone 20s
24mg hydromorphone

200mcg fentanyl

200mg morphine

500mg hydrocoone cwe

32mg suboxone

200mg demerol

3 grams heroin




e

[Juko]

80 mg oxy
is the only definite measure swim has. after that he snorted heroin for quite a while. i am sure he got up to 160 oxy, cause dope became half the strength as when he started. and that was after blowing 80 mg oxy's. however swim's been clean for 50 days today.

but hey drugs are bad, what do high tolerance's matter? once you go about snorting whole oxy 80's you're hooked.