Have you ever killed multi-drug resistant bacteria.....on weed?

[Beeker]

Marijuana ... is there anything it can't do?!




Killing bacteria with cannabis

By Yun Xie | Published: August 26, 2008 - 03:31PM CT


Pharmacists and chemists have found another use for the multipurpose cannabis as a source of antibacterial chemicals for multidrug resistant bacteria. Ironically, inhaling cannabis is known to damage the lung's ability to fend off invading pathogens, but the ingredients in cannabis, particularly the cannabinoids, have antiseptic properties. Although scattered research has been conducted since the 1950s, no comprehensive study existed that relates the structure of cannabinoids with antibacterial activity. Giovanni Appendino, Simon Gibbons, and coworkers attempted to remedy that problem by examining the activity of five common cannabinoids and their synthetic derivatives.



Five of the most common cannabinoids.

All five cannabinoids (THC, CBD, CBG, CBC, and CBN) were potent against bacteria. Notably, they performed well against bacteria that were known to be multidrug resistant, like the strains of MRSA that plagued U.K. hospitals. CBD and CBG have the most potential for consumer use because they are nonpsychotropic.

Besides identifying antibacterial capability, the researchers wanted to figure out why these cannabinoids are so good at killing bacteria. They obviously are very effective at specifically targeting some vital process in the bacteria. Unfortunately, even after extensive work at modifying the cannabinoids and comparing their activities, that targeting mechanism remains a mystery. The scientists were able to figure out that the position of the n-pentyl chain (orange) relative to the terpenoid moiety (blue) serves to control lipid affinity.

These cannabinoids are promising enough to warrant rigorous clinical trials. They are applicable as topical antiseptics, biodegradable antibacterial compounds for cosmetics, and systematic antibacterial agents.

Reputation Comments on this post:

	More good news. Thanks for sharing.
	Beautiful. :)

[purplehaze]

Ha, thats great. More and more uses come from this illegal drug. Next I think they should do trials to make rainX with THC since it's practically water repellent. Then onto the next application.

[Metomni]

Awesome. Nice find.

[Expat98]

Marijuana ingredient may fight bacteria

By Henry Fountain
September 7, 2008

Marijuana may be something of a wonder drug — though perhaps not in the way you might think.

Researchers in Italy and Britain have found that the main active ingredient in marijuana — tetrahydrocannabinol, or THC — and related compounds show promise as antibacterial agents, particularly against microbial strains that are already resistant to several classes of drugs.

It has been known for decades that Cannabis sativa has antibacterial properties. Experiments in the 1950s tested various marijuana preparations against skin and other infections, but researchers at the time had little understanding of marijuana's chemical makeup.

The current research, by Giovanni Appendino of the University of the Eastern Piedmont and colleagues and published in The Journal of Natural Products, looked at the antibacterial activity of the five most common cannabinoids. All were found effective against several common multi-resistant bacterial strains, although, perhaps understandably, the researchers suggested that the nonpsychotropic cannabinoids might prove more promising for eventual use.

The researchers say they don't know how the cannabinoids work, and whether they would be effective as systemic antibiotics would require much more research and trials. But the compounds may prove useful sooner as a topical agent against methicillin-resistant Staphylococcus aureus, or MRSA, to prevent the microbes from colonizing on the skin.

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http://www.iht.com/articles/2008/09/...e/09obdrug.php