Health - Max amount of Acetaminophen swimmies have taken in one day

[eklypised]

Swim was wondering the max amount of Acetaminophen other swims have taken in a 24 hour period?

[tryptamaster]

1.5 grams

[Panthers007]

There are a lot of SWIM's wandering about the planet with 1/2 a liver as a result of eating acetaminophen (paracetamol) mixed with such as codeine and hydrocodone. The thing is - they don't know they have seriously damaged their livers. They blindly continue in their course of blindly poisoning themselves. Until one day...THUD!

[Ontherooftops]

How much a swimmer has taken and survived isn't important, what's important is not to to take over 2000mg in a 24hr period. Some may survive excessive doses, many do, but that doesn't mean there won't be other symptoms from the damage the overdose does to one's liver in the future.

In ignorance, a young swim once took 9100mgs (canadian otc codiene... a bad comedown... you get the idea)

He survived, but not without some rather horrible side effects. He is very thankful that he is still one piece after this idiocy, he wouldn't wish acetaminophen poisoning on anyone.

[newgrower]

Liver pays dearly now for youthful magic moments. But rock on completely with some brand new components.

If swiy wants the other stuff mixed in, swiy might want to check out this:
http://www.drugs-forum.com/forum/sho...ter+extraction

[cuddlesthefox]

Swim once managed to neck down 44 x 500mg. This was a cry for help rather than a recreational thing. Luckily, swim's still here. How? swim don't have a clue. Swim just felt like shit in a world of shit for a week. Ignorance was bliss because swim didn't realise then just how dangerous that stuff is. Perhaps swims liver may not be what it was because of it.

[eklypised]

swimm took 4000mgs yesterday starting at 4pm it is now over the 24 hour period is it okay if swim takes just a 1000mgs today?

[TheNewLeft]

swim once took 20 5/325 percocets...spaced out over about 16 hours.....in 4 equal doses of 5 pills each every 4 hours or so.

[Richard_smoker]

There is debate among community leaders concerning this subject and like almost everything that involves a chronic, continued battery of insults to the liver over a long, long period of time, it is nearly impossible to know much of ANYTHING for sure (especially when cumulative factors come into play). hence the "educated guess" which, if a physician made the guess, then as soon as he utters his guess, it suddenly becomes "THE ANSWER." lol

People who play it on the safe side will max-out at 3,000mg (3 grams) per day. These individuals also, by and large, do NOT ingest alcoholic beverages, as these tend to rape and pillage the innocent little helpatocytes (liver cells) with all the 14 inch cock of "Long" Johnnie Holmes...after he's done banging your canaliculi, and tired of giving himself a taint tickler with your gallbladder, he will likely just kind a hang out.

Reputation Comments on this post:

Made me laugh.

[Solinari]

Although i am sure most of us know, i will mention that 4000mg is the maximum daily (24 hour!) allowance in divided doses at 1000mg at any one time with at least 6 hours between doses. Personally i would only ever take 1000mg four times in 24 hours if i had severe toothache or something like that, with no access to anything else.

On another note, it seems to me that trying to commit suicide by taking large amounts of paracetamol is probably one of the worst ways to die. It probably won't kill you outright but it will make you violently sick and extremely ill, and in the end it will probably cause serious liver damage or liver failure that will kill you in a horrible slow manner. I must add that this is speculation on my part, i am only going by what i have read.

[sknkv2]

SWIM has had tonsillitis past few days and at one point took something like 9-10 grams of it over 24 hours. this was 3 lemsips (1 g each), 11 paracetamol extra (500 mg acetaminophen, 10 mg codeine ea), and 3 prodeine (500 mg acetaminophen, 30 mg codeine ea).

Not hard to see how it adds up quickly.

[Solinari]

Off your head, why would you do that? Causing more harm than good.

[sknkv2]

It's only double the label dosage, those things are set based on what the minimum should be and then taking even more off that just to be safe. SWIM doesn't see too many problems arising out of using that much on the rare occasion, he reports he feels as good as always.

[Micklemouse]

Please read the article linked to in paracetamol - no dangerous a drug out there.

Whilst many take outrageous amounts of paracetamol & survive, the lottery dictates that there is always the chance that the slightest overdose could be fatal. Do not mess with this substance.

From 2002

http://www.scienceblog.com/community.../20021040.html

Accidental overdose with Acetaminophen (Paracetamol) carries a greater risk of death

New research published in the latest issue of Critical Care shows that patients who are admitted to hospital because of accidental poisoning with acetaminophen (paracetamol) are at greater risk of liver failure and death than those whose take an overdose intentionally. This is because people who poison themselves accidentally often attend hospital much later and are more likely to be alcohol abusers, two factors that greatly increase the chances of death.Acetaminophen is an effective and safe painkiller. However, if taken in excess it can be fatal. Taking an acetaminophen overdose overwhelms the liver's ability to process the drug. The excess acetaminophen is then processed into toxic chemicals, which can kill liver cells. If enough cells are killed the patient can die from liver failure. Fortunately, a drug called N-acetylcysteine (NAC) can be given as an effective antidote for acetaminophen poisoning if the patient is treated within 12 hours of the overdose.
Doctors from the US analysed the medical records of 93 patients who were hospitalised as a result of an acetaminophen overdose, 80 were classed as suicidal with the remainder having accidentally overdosed in attempt to relieve their pain. They found that those patients who had accidentally overdosed fared less well than those who attempted suicide.
This was surprising given that the levels of acetaminophen were much lower in the patients who had taken the overdose by accident compared with those who had deliberately overdosed. Analysis of the patient's case histories revealed that those patients who overdosed by accident waited longer before going to hospital. The effectiveness of NAC, as an antidote to acetaminophen is reduced if it cannot be given at least 12 hours after an overdose is taken.
It was also shown that the patients who overdosed by accident and were more likely to heavy drinkers. Acetaminophen toxicity is made worse by alcohol consumption because the liver is attempting to eliminate two drugs from the body at the same time using a similar biochemical pathway. Thus the toxicity of acetaminophen is increased, leading to a higher risk of liver damage and death.
Acetaminophen poisoning is one of the most common types of poisoning and is placing an enormous financial burden on hospitals particularly as these patients are traditionally managed in intensive care units. The authors of this study believe at least $500, 000 could be saved in their hospital alone if patients, who have overdosed deliberately, with no history of alcohol abuse, were managed on medical floors. However they maintain that cases of accidental poisoning and in situations if the case history was in doubt should be managed in intensive care units.
This research article is freely available in Critical Care, a journal published by BioMed Central, simply visit: http://ccforum.com/content/6/2/155.
For further information contact the author, Dr Chirag R Parikh.
An accompanying commentary by can be found in the same issue of Critical Care, for access to this article visit: http://ccforum.com/info/media/cc-6-2-108.pdf.
Any articles published using the material featured in these articles should reference Critical Care, a journal published by BioMed Central. To read further press releases from Critical Care visit: http://ccforum.com/info/media/press.asp.
Critical Care is a journal published by BioMed Central, an independent online publishing house committed to providing immediate free access to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science. In addition to open-access original research, BioMed Central also publishes reviews, abstracts and subscription-based content.
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This article comes from Science Blog. Copyright © 2004

[Dexyfiend]

SWIM just came out of hospital cos of acetaminophen poisioning. Somewhere between 4 - 8 grams. He did a CWE on some codeine pills for toothache but stupidly didnt let it get cold enough and injested an unknown amount. The stupid thing is he's done this once before about a year ago.
They (the docs) gave him the antedote and now he feels fine. They did a liver function test and told me it's not working at full capacity for someone my age but is still OK and nothing to worry about, I figure working at 85% - 90% capacity... swim can live with that.
The thing is he's pretty sure the damage didn't occur from this one off OD but from 14yrs of chronic amphetamine abuse but this is the life he leads and he loves to party and isn't about to quit anytime soon if ever.

Quick question for those in the know: Just how damaging are amphetamines (methylated or not) to the liver??? He figures it can't be as bad as alcahol but really has no idea.

[Micklemouse]

Please do not divert this thread. If you have any questions about amfetamines & damage to the liver please post in the amfetamine or pharmacology forum.

[allyourbase]

swim advises never to exceed two and a half grams of acetominophen in any given 24 hour period.

[KomodoMK]

I read somewhere that liver toxicity begins with paracetamol (APAP) with single doses as low as 10,000mg (10grams) or 200mg/kg body weight (whichever is lower). However, if this was repeated day after day or multiple doses on single days the cumulative effect could be potentially very damaging to your liver.

Highly recommended to perform a CWE if you or your lab animals intend to ingest large amounts of codeine from OTC medications.

[meaculpa]

15000mgs [30 x 8/500mg] everyday for about 5 years, blood tests showed early signs of liver damage, now down to 6000 [10 x 8/500mg] per day

[Micklemouse]

Jesus, this thread is beginning to read like a Remembrance day roll call in advance. 6 grams is still a daily overdose - there is no reason to be taking that amount of paracetamol other than laziness or ignorance of cold water extraction.

People, please do a search on CWE ( cold water extraction) & use this shockingly easy technique. Done properly it saves lives.

Remember kittlings, yellow is not a good people colour & paracetamol poisoning is one of the nastiest ways to die.

[Solinari]

Originally Posted by insert_username_here

It's only double the label dosage, those things are set based on what the minimum should be and then taking even more off that just to be safe. SWIM doesn't see too many problems arising out of using that much on the rare occasion, he reports he feels as good as always.

It's 2.5 times the recommended maximum dose and it is a toxic dose of paracetamol. The thing is, taking such high doses of paracetamol isn't going to have any benefit what so ever and certainly isn't going to treat tonsillitis, if anything it's going to cause more harm than good. That's my point.

Meaculp, you are off your head and you need help, you are heading for an early grave with that level of abuse.

[meaculpa]

swim knows she needs help as she also drinks alcohol [only beer] most nights. swim is not a recreational user but is self medicating, she has sought proffesional help in the past for her many issues but nothing [CBT, counselling, for anxiety/depression and methadone for codeine addiction] has helped, which is why she resorts to self medicating with codeine. before joining this forum swim had no idea about CWE but will definately give it a go, as swim finds it impossible to give up last 10 pills

[KomodoMK]

What about slowly tapering the dose down? Try going down to 9 for a week, then 8, then 7 and so on?

Wish SWIY the best of luck, and make sure SWIY gives that CWE a go if you intend to continue.

[meaculpa]

thank you, but swim tried this before and although it worked and swim was codeine free for a while she then resorted to self-harming instead. swim doesn`t want this to happen again so will try CWE until she can sort out her messed up head

[Lobsang]

The way I see it is like this. If one takes the maximum allowable dose of acetaminophen per day for years they will not likley have a problem with their liver. However they are much more likley to get analgesic Nephropathy. So the issue with chronic use at reasonible doses the issue becomes the kidneys...Not the liver.

Now as far as the liver goes. One really should not be drinking alcohol at all with acetaminophen and one should not exceed maximum doses per day.