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Research Chemicals Piperazines, Phenethylamines, Tryptamines & other designer drugs.

 
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  #1  
Old 24-08-2008, 15:30
Alfa Alfa is nu online
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Rti-55

Please post info about RTI-55 here.

Can anyone add information about:
  • names / synonyms
  • molecule
  • dose
  • duration
  • side effects
  • legal status
  • have there been any reported incidents with this compound?
  • since when has this research chemical been available?
  • stability of the molecule / compound

Names: RTI-55

Experiences with RTI-55 should be discussed in a seperate thread.
These documents about RTI-55 are in the file archive
RTI-55 pics
  #2  
Old 31-08-2008, 22:46
runitsthepolice runitsthepolice is offline
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Re: Rti-55

(-)-2β-Carbomethoxy-3β-(4-iodophenyl)tropane (β-CIT or RTI-55) is a stimulant drug used in scientific research and with some medical uses, which was developed in the early 1990s.[1] β-CIT is a phenyltropane based dopamine reuptake inhibitor and is derived from methylecgonidine. β-CIT is one of the most potent phenyltropane stimulants that is commercially available, which limits its use in humans, as it might have significant abuse potential if used outside of a strictly controlled medical setting.[2] When radiolabeled with iodine-123, it is known as iometopane.

β-CIT is mainly used in scientific research into the dopamine reuptake transporter. Various radiolabelled forms of β-CIT (with different radioactive isotopes of iodine used depending on the application) are used in both humans and animals to map the distribution of dopamine transporters and serotonin transporters in the brain.[3][4] The main practical application for this drug in medicine is to assess the rate of dopamine neuron degradation in the brains of sufferers of Parkinson's disease[5][6] and some other conditions such as progressive supranuclear palsy.[7]

β-CIT is legal in all countries throughout the world as of 2007. Some jurisdictions such as the USA, Canada, Australia and New Zealand might however consider β-CIT to be a controlled substance analogue of cocaine on the grounds of its related chemical structure.

Taken from wikipedia, can't find much else about this

Post Quality Evaluations:
Thanks for the contribution.
Good info on RTI-55 history and uses.

Last edited by Alfa; 09-08-2009 at 00:22.
  #3  
Old 31-08-2008, 23:55
Alfa Alfa is nu online
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Re: Rti-55

Check medline and the file archive for abstracts.
  #4  
Old 17-07-2009, 19:40
runitsthepolice runitsthepolice is offline
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Re: Rti-55

Another name for it is Iometopane, it is a class A drug in the UK as of August 2008.

It might be subject to the analog act in the United States due to its structural similarity to cocaine.

Can anyone find any experiences with this chemical?

Last edited by runitsthepolice; 19-07-2009 at 13:13.
  #5  
Old 19-07-2009, 13:58
runitsthepolice runitsthepolice is offline
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Re: Rti-55

Okay so swim is pretty interested in RTI-55

This is a list of synonyms for RTI-55 found on another website:
beta-CIT
RTI 55
MOLI000906
[125I]RTI-55
CID108220
PDSP2_000645
2-Carbomethoxy-3-(4-iodophenyl)tropane
RTI 4229-55
RTI 4229-98
2beta-Carbomethoxy-3beta-(4-iodophenyl)tropane
3-(4-Iodophenyl)tropane-2-carboxylic acid methyl ester
133647-95-7
135416-43-2
135500-23-1
8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, methyl ester, (1R,2S,3S,5S)-
8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, methyl ester, (1R,2S,3S,5S)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, methyl ester, (1R-(exo,exo))-
8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, methyl ester, (1R-(exo,exo))-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1)
8-azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl-, methyl ester, (1R,2S,3S,5S)-

This radio-labeled chemical is available to licensed researchers. Would the fact that it is radio-labeled mean that attempting to ingest it recreationally would likely result in unwanted side effects? Can anyone explain how a chemical becomes radio-labeled?

Last edited by Alfa; 29-07-2009 at 23:19. Reason: had a shitload of images in accidentally copy-pasted the text
  #6  
Old 19-07-2009, 17:22
nibble nibble is offline
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Re: Rti-55

Quote:
Originally Posted by runitsthepolice View Post
This radio-labeled chemical is available to licensed researchers. Would the fact that it is radio-labeled mean that attempting to ingest it recreationally would likely result in unwanted side effects? Can anyone explain how a chemical becomes radio-labeled?
It shouldn't cause problems, the radioactivity isn't significant to do any damage beyond the background radiation encountered daily. Shulgin often used radio-labelled ligands on himself and willing fellow researchers. Depending on the isotope used I suppose, if it were undergoing gamma decay then that would indeed prove to be harmful but that isn't going to be the case here as far as I know.

Radio-labelling is achieved by replacing an atom in the compounds structure with a radioactive isotope of that atom, in this case iodine. As the unstable isotope decays it emits different particles depending on the type of decay it is undergoing.

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Good info on radio-labeling
  #7  
Old 29-07-2009, 12:17
bushman bushman is offline
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Re: Rti-55

As radioactivity is readily detected and methods of detection are extremely sensative, only a tiny amount of radiolabelled substance is needed, not enough to causes anything harmful.

The main danger/disadvantage of using radiolabelled substances is the "isoptope effect".
This is basically that molecules containing different isotopes of the same atom will behave is slightly different ways to that of the natural isotope (rate of metabolism etc). This effect is only really a problem for smaller molecules.

They are used, in this context, to investigate metabolic pathways and for translocation studies (basically to see where the metabolites end up).

So, as Nibble said, the dangers (of radiolabelling) are negligable really.

Good luck...

Last edited by bushman; 05-08-2009 at 16:15.
  #8  
Old 29-07-2009, 12:36
old hippie 56 old hippie 56 is offline
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Re: Rti-55

This product contains a chemical (s) known to the state of California to cause cancer. This product also contains a component which is flammable and explosive may be fatal if swallowed or inhaled (4000 ppm dangerous to life or health). This component causes central nervous depression and may be poisonous upon decomposition.


Source address was deleted.
MSDS available

Last edited by Jatelka; 05-08-2009 at 06:25.
  #9  
Old 04-08-2009, 23:41
NeuroChi NeuroChi is offline
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Re: Rti-55

Could you elaborate OH? What is the chemical that is known to cause cancer? You link is broken as well.
  #10  
Old 05-08-2009, 05:03
old hippie 56 old hippie 56 is offline
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Re: Rti-55

The link was a source, and thinking the chemical in question might be this one-acetonitrile.
  #11  
Old 05-08-2009, 05:55
runitsthepolice runitsthepolice is offline
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Re: Rti-55

Edit the link out of that post old hippie I was able to figure out the source in 5 seconds.
  #12  
Old 05-08-2009, 07:21
old hippie 56 old hippie 56 is offline
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Re: Rti-55

Quote:
Originally Posted by runitsthepolice View Post
Edit the link out of that post old hippie I was able to figure out the source in 5 seconds.
Ms. J beat me to it. But thanks for the heads up anyway.
  #13  
Old 08-08-2009, 14:55
0utrider 0utrider is offline
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Re: Rti-55

so is this something that can be (ab)used? whats the dosage, duration etc. ?
  #14  
Old 09-08-2009, 00:04
runitsthepolice runitsthepolice is offline
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Re: Rti-55

Quote:
Originally Posted by runitsthepolice View Post
β-CIT is one of the most potent phenyltropane stimulants that is commercially available, which limits its use in humans, as it might have significant abuse potential if used outside of a strictly controlled medical setting.
It's probably awesome.
  #15  
Old 07-01-2013, 22:30
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Re: Rti-55

Quote:
Originally Posted by runitsthepolice View Post
Another name for it is Iometopane, it is a class A drug in the UK as of August 2008.

It might be subject to the analog act in the United States due to its structural similarity to cocaine.

Can anyone find any experiences with this chemical?
To clarify this statement on UK law...
As far as I am aware, this is how it's covered;

Misuse of Drugs Act
Class A
Paragraph 1
(e) any compound (not being a compound for the time being specified in sub-paragraph (a) above) structurally derived from pethidine by modification in any of the following ways, that is to say,

(i) by replacement of the 1-methyl group by an acyl, alkyl whether or not unsaturated, benzyl or phenethyl group, whether or not further substituted;

(ii) by substitution in the piperidine ring with alkyl or alkenyl groups or with a propano bridge, whether or not further substituted;

(iii) by substitution in the 4-phenyl ring wiith alkyl, alkoxy, aryloxy, halogeno or haloalkyl groups;

(iv) by replacement of the 4-ethoxycarbonyl by any other alkoxycarbonyl or any alkoxyalkyl or acyloxy group;

(v) by formation of an N-oxide or of a quaternary base.

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