Pharmacology - Research chemicals as cocaine substitutes (dopamine stimulants)

[Alfa]

There are more and more research chemicals with a dopaminergic (affects dopamine system) effect. This type of research chemical is particularly worrisome because of the level of craving and health risks accompanied by their effect.

At the same time they are very interesting to cocaine users.

Please list research chemicals that affect the dopamine system, and can therefore be seen as cocaine substitutes.

Here are some cocaine substitutes:
Fluorotropacocaine
Desoxypipradrol
3-pseudotropyl,4-fluorobenzoate
Diphenyl-2-Pyrrolidinyl-Methanol (diphenylprolinol)
Naphthylisopropylamine
Rti-55

To a lesser degree the following stimulants may be interesting as well:
Mdpv
Methylone (mostly an ecstasy type stimulant, but does give dopamine type rewarding feeling)

[jungle]

what about propylhexedrine?

it is not really a research chemical, but it's a dopamine stimulant too, i guess.
as far as i know propylhexedrine is basically legal in the us.

[Alfa]

propylhexedrine is an adrenergic stimulant, not a dopaminergic stimulant. It would serve as an amphetamine substitute, not a cocaine substitute.

[AbbaZaba]

Methylenedioxypyrovalerone (MDPV)

Case closed.

AbbaZaba added 2 Minutes and 56 Seconds later...

Aw, swiy already listed it
Eureka for a split sec at least...

[bhmoab1]

swim would also say mdpv is pretty damn close, but not quite the rush/euphoria as cocaine. Swim would also consider it more addicting, and a drug where you want to keep doing more even moreso than coke. Although the comedown will sure make you wish you didnt keep partaking.

Swim has found it easy to go through 100mg or more in a good run on mdpv. NOT ADVISED

[AbbaZaba]

Alfa:
Since swiy hasn't gotten any new ideas yet- how about mitragynine?
9-methoxy-corynantheidine- Its use(chewed in leaf form) was common among Thai laborers because of its stimulating quality and narcotic-like buzz. Now 15x extracts are floating around... Swiz is a bit curious about kratom himself.

Found in a plant called Kratom as you most likely already know. One swimmer could obtain a leaf extract and perform an alcohol extraction to get mitragynine and some other alkaloids into a more potent and manageable mass. Is this possible?

[allyourbase]

swim can say as an occasional user of morphine meconate (natural salt) that it has stimulant properties. swim has also tried kratom, and finds this to be a commonality, including the crash afterward, though morphine's is much harder. swim thinks this has more to do with certain endorphins released by proper mu agonism than it does with dopamine, as he has also tried individually a number of k agonists and other dopamine agonists and reuptake inhibitors, and is familiar with their feeling.

also the "crash" is entirely different. with the mu agonists its like instasleep, whereas with dopanergic compounds it is a fading "geek".

[vantranist]

Isn't 3-pseudotropyl,4-fluorobenzoate The same thing as Flourotropicocaine?

[konshuss]

Very interesting thread -- anyone have any more info?

My cat has not tried any of the above listed RC's except MDPV, which she enjoys orally at low doses.

[Richi]

SWIM got a taste of a very cocaine like research chemical, but he doesn't know which one it was. The onset was faster, the rush was a little more powerful, but the euphoric effects were slightly less than cocaine. It had a psychedelic edge to it, looking at the brick sidewalk pattern in bright sunlight made it seem as though everything was vibrant and vivid.

All from approximately 60 mg of this crystalline white powder, which looked exactly like ketamine.

[DarkDead]

Dimethocaine seems to be one of the closest substitutes. According to Wikipedia it has both stimulant and local anesthetic proprieties in the same dose range as cocaine. Although in the Dimethocaine experiences thread SWItyranny4u reports it "feels like Cocaine light".

Wikipedia also has an extensive list of cocaine analogues worth checking out.

Reputation Comments on this post:

Why not post the names here, instead of telling people to go look somehwere else?

[Richi]

I forgot to mention that the person who isn't me who tried such a substance said that it had no anesthetic properties. It must have been something else.

[DarkDead]

As asked, here is the list of cocaine analogues (it's quite extensive):

Analogues with both stimulant & local anesthetic effects.
* Dimethocaine/Larocaine (DMC)
* 3-(p-Fluorobenzoyloxy)tropane (30% stimulant potency of cocaine & equipotent as an anaesthetic)

Analogues for stimulant effects with local anesthetic effects removed
* β-CIT/Iometopane (RTI-55)
* β-CPPIT (RTI-177)
* FE-β-CPPIT
* FP-β-CPPIT
* Altropane
* Brasofensine
* CFT (3-10× more potent than cocaine with 7× duration)
* Dichloropane (slower onset than cocaine and longer duration of action)
* Difluoropine (more selective as a DARI than cocaine. Also an anticholinergic & antihistamine)
* Ioflupane (¹²³I)
* Nocaine
* Tesofensine
* Troparil (CPT) (equipotent to cocaine with a several times lengthened duration)
* Tropoxane
* HDMP-28
* PIT (10× the potency of cocaine as a SRI)
* PTT (20× the potency of cocaine as a DARI with NE selectivity)
* RTI-121 (slower onset at DARI binding than cocaine and less non-selective at binding)
* RTI-126 (5× more potent than cocaine, unselective)
* RTI-150 (5× the potency of cocaine, selective for DA)
* RTI-336 (20× the affinity for DAT more than cocaine, slow onset, long duration of action, mild stimulant effects.)
* WF-23 (500-800× more potent than cocaine at DARI & SRI)
* WF-33

Analogues made as local anesthetics, with stimulant effects removed
* Amylocaine
* Articaine
* Benzocaine
* Bupivacaine (Marcaine, Sensorcaine, Vivacaine)
* Butacaine
* Carticaine
* Chloroprocaine (Nesacaine)
* Cinchocaine/Dibucaine (Nupercaine)
* Cyclomethycaine (Surfacaine, Topocaine)
* Etidocaine
* Hexylcaine (Cyclaine, Osmocaine)
* Levobupivacaine (Chirocaine)
* Lidocaine/Lignocaine (Xylocaine)
* Mepivacaine (Carbocaine, Polocaine)
* Meprylcaine/Oracaine
* Metabutozycaine (Primacaine)
* Piperocaine (Metycaine)
* Prilocaine
* Propoxycaine/Ravocaine
* Procaine/Novocaine (Novocain)
* Proparacaine/Alcaine
* Risocaine
* Ropivacaine
* Tetracaine/Amethocaine (Pontocaine)
* Trimecaine

Analogues for other purposes
* Homatropine
* Procainamide

Source: Wikipedia