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Research Chemicals Piperazines, Phenethylamines, Tryptamines & other designer drugs.

 
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  #1  
Old 24-08-2008, 15:24
Alfa Alfa is offline
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Research chemicals as cocaine substitutes (dopamine stimulants)

There are more and more research chemicals with a dopaminergic (affects dopamine system) effect. This type of research chemical is particularly worrisome because of the level of craving and health risks accompanied by their effect.

At the same time they are very interesting to cocaine users.

Please list research chemicals that affect the dopamine system, and can therefore be seen as cocaine substitutes.

Here are some cocaine substitutes:
Fluorotropacocaine
Desoxypipradrol
3-pseudotropyl,4-fluorobenzoate
Diphenyl-2-Pyrrolidinyl-Methanol (diphenylprolinol)
Naphthylisopropylamine
Rti-55

To a lesser degree the following stimulants may be interesting as well:
Mdpv
Methylone (mostly an ecstasy type stimulant, but does give dopamine type rewarding feeling)

Last edited by Alfa; 24-08-2008 at 15:31.
  #2  
Old 01-09-2008, 01:44
jungle jungle is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

what about propylhexedrine?

it is not really a research chemical, but it's a dopamine stimulant too, i guess.
as far as i know propylhexedrine is basically legal in the us.
  #3  
Old 01-09-2008, 01:49
Alfa Alfa is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

propylhexedrine is an adrenergic stimulant, not a dopaminergic stimulant. It would serve as an amphetamine substitute, not a cocaine substitute.

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  #4  
Old 01-09-2008, 02:37
AbbaZaba AbbaZaba is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

Methylenedioxypyrovalerone (MDPV)

Case closed.

AbbaZaba added 2 Minutes and 56 Seconds later...

Aw, swiy already listed it
Eureka for a split sec at least...

Last edited by AbbaZaba; 01-09-2008 at 02:37. Reason: Automerged Doublepost
  #5  
Old 01-09-2008, 06:06
bhmoab1 bhmoab1 is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

swim would also say mdpv is pretty damn close, but not quite the rush/euphoria as cocaine. Swim would also consider it more addicting, and a drug where you want to keep doing more even moreso than coke. Although the comedown will sure make you wish you didnt keep partaking.

Swim has found it easy to go through 100mg or more in a good run on mdpv. NOT ADVISED
  #6  
Old 01-09-2008, 06:25
AbbaZaba AbbaZaba is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

Alfa:
Since swiy hasn't gotten any new ideas yet- how about mitragynine?
9-methoxy-corynantheidine- Its use(chewed in leaf form) was common among Thai laborers because of its stimulating quality and narcotic-like buzz. Now 15x extracts are floating around... Swiz is a bit curious about kratom himself.

Found in a plant called Kratom as you most likely already know. One swimmer could obtain a leaf extract and perform an alcohol extraction to get mitragynine and some other alkaloids into a more potent and manageable mass. Is this possible?
  #7  
Old 01-09-2008, 11:07
allyourbase allyourbase is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

swim can say as an occasional user of morphine meconate (natural salt) that it has stimulant properties. swim has also tried kratom, and finds this to be a commonality, including the crash afterward, though morphine's is much harder. swim thinks this has more to do with certain endorphins released by proper mu agonism than it does with dopamine, as he has also tried individually a number of k agonists and other dopamine agonists and reuptake inhibitors, and is familiar with their feeling.

also the "crash" is entirely different. with the mu agonists its like instasleep, whereas with dopanergic compounds it is a fading "geek".
  #8  
Old 06-09-2008, 21:50
vantranist vantranist is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

Isn't 3-pseudotropyl,4-fluorobenzoate The same thing as Flourotropicocaine?
  #9  
Old 02-11-2008, 19:08
konshuss konshuss is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

Very interesting thread -- anyone have any more info?

My cat has not tried any of the above listed RC's except MDPV, which she enjoys orally at low doses.
  #10  
Old 04-08-2009, 23:37
NeuroChi NeuroChi is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

SWIM got a taste of a very cocaine like research chemical, but he doesn't know which one it was. The onset was faster, the rush was a little more powerful, but the euphoric effects were slightly less than cocaine. It had a psychedelic edge to it, looking at the brick sidewalk pattern in bright sunlight made it seem as though everything was vibrant and vivid.

All from approximately 60 mg of this crystalline white powder, which looked exactly like ketamine.
  #11  
Old 07-08-2009, 10:25
DarkDead DarkDead is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

Dimethocaine seems to be one of the closest substitutes. According to Wikipedia it has both stimulant and local anesthetic proprieties in the same dose range as cocaine. Although in the Dimethocaine experiences thread SWItyranny4u reports it "feels like Cocaine light".

Wikipedia also has an extensive list of cocaine analogues worth checking out.

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Why not post the names here, instead of telling people to go look somehwere else?

Last edited by DarkDead; 07-08-2009 at 10:31.
  #12  
Old 07-08-2009, 14:39
NeuroChi NeuroChi is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

I forgot to mention that the person who isn't me who tried such a substance said that it had no anesthetic properties. It must have been something else.
  #13  
Old 07-08-2009, 15:10
DarkDead DarkDead is offline
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

As asked, here is the list of cocaine analogues (it's quite extensive):
Quote:
Analogues with both stimulant & local anesthetic effects.
* Dimethocaine/Larocaine (DMC)
* 3-(p-Fluorobenzoyloxy)tropane (30% stimulant potency of cocaine & equipotent as an anaesthetic)

Analogues for stimulant effects with local anesthetic effects removed
* β-CIT/Iometopane (RTI-55)
* β-CPPIT (RTI-177)
* FE-β-CPPIT
* FP-β-CPPIT
* Altropane
* Brasofensine
* CFT (3-10 more potent than cocaine with 7 duration)
* Dichloropane (slower onset than cocaine and longer duration of action)
* Difluoropine (more selective as a DARI than cocaine. Also an anticholinergic & antihistamine)
* Ioflupane (I)
* Nocaine
* Tesofensine
* Troparil (CPT) (equipotent to cocaine with a several times lengthened duration)
* Tropoxane
* HDMP-28
* PIT (10 the potency of cocaine as a SRI)
* PTT (20 the potency of cocaine as a DARI with NE selectivity)
* RTI-121 (slower onset at DARI binding than cocaine and less non-selective at binding)
* RTI-126 (5 more potent than cocaine, unselective)
* RTI-150 (5 the potency of cocaine, selective for DA)
* RTI-336 (20 the affinity for DAT more than cocaine, slow onset, long duration of action, mild stimulant effects.)
* WF-23 (500-800 more potent than cocaine at DARI & SRI)
* WF-33

Analogues made as local anesthetics, with stimulant effects removed
* Amylocaine
* Articaine
* Benzocaine
* Bupivacaine (Marcaine, Sensorcaine, Vivacaine)
* Butacaine
* Carticaine
* Chloroprocaine (Nesacaine)
* Cinchocaine/Dibucaine (Nupercaine)
* Cyclomethycaine (Surfacaine, Topocaine)
* Etidocaine
* Hexylcaine (Cyclaine, Osmocaine)
* Levobupivacaine (Chirocaine)
* Lidocaine/Lignocaine (Xylocaine)
* Mepivacaine (Carbocaine, Polocaine)
* Meprylcaine/Oracaine
* Metabutozycaine (Primacaine)
* Piperocaine (Metycaine)
* Prilocaine
* Propoxycaine/Ravocaine
* Procaine/Novocaine (Novocain)
* Proparacaine/Alcaine
* Risocaine
* Ropivacaine
* Tetracaine/Amethocaine (Pontocaine)
* Trimecaine

Analogues for other purposes
* Homatropine
* Procainamide
Source: Wikipedia
  #14  
Old 14-08-2009, 23:54
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Re: Research chemicals as cocaine substitutes (dopamine stimulants)

A study utilizing WF-23 has been uploaded, entitled:

Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain

A relevant passage from the discussion:

Quote:
Originally Posted by Kerry Ann O’Connor, Timothy C. Gregg, Huw M.L. Davies, Steven R. Childers
The potent tropane analog WF-23 has been shown to increase locomotor activity in rats and substitute for cocaine and maintain cocaine responding in self-administration paradigms in both rodents and non-human primates. These findings clearly demonstrate that acute behaviors produced by WF-23 are similar to those elicited by cocaine. Previous results showing that a single administration of WF-23 produced long-term blockade of both DAT and SERT binding suggested tha tthis tropane analog would be useful in producing long-term increases in biogenic amines after chronic administration.

The current study shows that chronic treatment with WF-23 produced reductions in monoamine receptor-stimulated GTPgammaS binding. Chronic treatment with WF-23 didn't alter -opioid stimulated GTPgammaS binding in the caudate/putamen, where significant decreases were observed in D2 receptor-stimulated GTPgammaS binding. Interestingly, these are different results than those seen following chronic cocaine binge treatment where increases have been shown in receptor density of -opioid receptors...The causes of this regional specificity in monamine receptor desensitization are not known, however, in the present study these differenes could arise from two separate sources: differences in receptor regulator mechanisms and differences in presynaptic activity of monoamine-releasing neurons.
And a few from the Results:

Quote:
Originally Posted by Kerry Ann O’Connor, Timothy C. Gregg, Huw M.L. Davies, Steven R. Childers
The current study shows that chronic treatment with WF-23 produced reductions in monoamine receptor stimulated GTPgammaS binding. These reductions were specific for a receptor/G-protein desensitization.

Previous studies showed that a single i.p. injection of 1mg/kg WF-23 significantly reduced radioligand binding to DAT in rat striatal membranes for up to five days; moreover, this treatment reduced DAT binding by 50% for two days...This treatment paradigm produced increases in locomotor activity, and stereotypic behaviors including head bobbing and rearing on the hind legs. There was no apparent loss of body mass in WF-23 treated animals over the course of treatment.

Chronic treatment of rats with WF-23 reduced 5-HT1a receptor labeling in hippocampus, but no changes were observed in septum...chronic treatment with WF-23 produced a 38% reduction in 5-HT1a receptor stimulated GTPgammaS binding in hippocampus, and no significant effect in other regions examined, including septum and dorsal raphe.

Chronic WF-23 treatment also produced significant reductions in alpha2-adrenergic receptor-stimulated GTPgammaS binding in amygdala...a 46% reduction...Desensitization was specific to the biogenic amine receptors: D2, 5-HT1a, and alpha2-adrenergic receptors.

Last edited by Terrapinzflyer; 10-09-2010 at 18:25.

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2-dpmp, cocaine alternatives, cocaine analogues, cocaine rc, desoxypipradrol, drug, rti-126, stimulant research chemicals

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