Other - DOC tolerance

[chillinwill]

Does anybody know how fast tolerance grows when using DOC and how long should my monkey wait before taking it again. Also, does 2ce have any cross tolerance with DOC?

[Samadhi]

You bet your bottom 2c-e is cross tolerant with DOC. Read up on the down-regulations of the 5-ht receptors by Psychedelics and swiy will get a better idea of the information to fully explain why that is

Clinically, tolerance can be gone in as little from 3-4 days but for the sake of the experience and just general use of such a heavy psychedelic swiy should wait a week before trying it again, or wait more, it will make the experience more rewarding.

And do please take care of swiy's body during and the day after a DOC trip. It is an substituted amphetamine, and sometimes people forget that.

[wintrojan2k]

my monkey finds weekly use to create some tolerance, but not much. This stuff is just explosive at 12mg, for my monkey, and it can have him wired for 48 hrs plus. If not for alprazolam and cannabis I'm not sure he could handle the rush! Even if he eats 6mg of xanax 10 hrs in, it won't kill it. It's very wearing, gonna have to keep it to once a month for me. It's not a "fun" RC, as my monkey says, visuals are intense, make sure you shit is straight upstairs this stuff can bring you places you don't want to be if your not careful. My monkey prefers to use at night as he can wander the dark golf course next to us and feel relatively safe irrespective of the display before him which is altogether another story

[Ace of Ace]

Swim did 11x hit accidentally and has a huge tolerance 2 months later

[enquirewithin]

Most psychedelics = a week or 10 days.

[Gradient]

I completely agree with Samadhi; receptor cross-tolerance is the main point here.
Solely for the sake of discussion...My chimp is convinced that the role of behavioral tolerance has a particularly strong and interesting relationship with psychedelics as well - especially those characterized by slightly longer durations, allowing for greater probability of behavioral habituation & long-term memory events. For example, having taken LSD two to three years prior to his first introduction to the chemical, my chimp anticipated the effects to a far higher degree upon subsequent escapades. The chimp was able to compensate for the startlingly potent sensory distortions a bit more - and for better or worse, he had a much more self-guided experience. He feels that this effect has a wide 'cross-tolerance'. For example, an experience with 2C-B might 'influence' an experience with 2C-E, in that one might have established somewhat of a context for the effects of the 2C-x family. Certainly not suggesting that at a certain point, they all sort of become vanilla - more that it becomes easier to become sensitive to the nuanced differences, and not be overcome or distracted by how generally altered one becomes.

Found a little study on behavioral-tolerance that develops with alcohol. I know, certainly not the same ballpark of compounds - but definitely evidence that the dynamic certainly exists outside of the already mentioned (and far more significant) receptor-tolerance. Here's a relevant quote from this article's abstract:

Both scientific and anecdotal evidence indicates that social drinkers can develop resistance (i.e., behavioral tolerance) to alcohol’s impairing effects over time. Although repeated exposure to alcohol is thought to explain tolerance development on a physiological level, the acquisition of behavioral tolerance appears to involve additional factors. In particular, learned associations between a drinker’s behavior following alcohol consumption and the subsequent consequences may play an important role. When favorable consequences result from displaying unimpaired (i.e., tolerant) behavior after drinking, a drinker learns to develop behavioral strategies to compensate for alcohol’s effects. From: Is Behavioral Tolerance Learned?

Since the behavioral states that psychedelics are capable of generating are far more diverse than those of alcohol, I'd think this dynamic might have an even greater significance to progressive psychedelic experiences. I could easily be wrong, and it's likely a highly subjective dynamic.