Opinions - Poll: Effects of combining alcohol with piracetam?

[Euphoric]

SWIM has heard mixed reports, some saying the can drink more, some saying they can drink less. SWIY's experience?

[Bajeda]

When my panda first began using piracetam he noticed a marked decrease in alcohol tolerance. This led to some unfortunate situations

Occasionally, if he has ceased regular use and takes a dose, he will notice a similar effect, though not as strong as when he first began regular use the initial time.

Otherwise, during regular use he didn't notice much of a difference. Hard to say what piracetam's effects were on my panda's alcohol use, as after a long period of using piracetam he couldn't remember if there were any differences in effects from before he was on the regimen. He can still drink as much as he used to, and feels that his tolerance is a bit high compared to many people, so he doesn't think the low-tolerance effect was long-lived.

Reputation Comments on this post:

thanks ;)

[Felix Guattari]

I got exceedingly smashed on the combo. I had my first breakthrough Salvia trip the same night. On the chance that it increases your brain's exposure to the alcohol, I'm not touching it again when on a racetam.

Reputation Comments on this post:

Thanks for sharing.

[shivakiva2112]

It takes longer for me to get drunk while taking piracetam, but the negative effects of alcohol consumption are more pronounced. It is a very bad combination.

Reputation Comments on this post:

Thanks for sharing.

[Happy234]

it is recommended to not mix alcohol and piracteam because something about piracteam does something with blood flow to the brain, where alcohol messes with it. thats why you feel your head throb.I just got done three months of piracteam and only drank one time because, I forgot.

[Bajeda]

Could you please provide some sort of empirical or at least theoretical basis for your claim Happy234?

[Happy234]

Originally Posted by Bajeda

Could you please provide some sort of empirical or at least theoretical basis for your claim Happy234?

As of now I can't find the studies. I think they acts on gaba receptors and alcohol can interupt piracetam's effects.

If it means a lot to any one type in piracetam, alcohol on p.u.b.m.e.d dot com, eight pages of studies, it might be there. I'm not really taking the time to find it because its not that important to me.I did hours of research before doing piracetam and during.I think i read it in a smart drug 's expert article. David Tol-something. Can't pinoint where I read it's been so long

[Expat98]

I'm also with the group who say that it's not good to take piracetam soon before drinking. But taking piracetam the next day or two AFTER drinking can be very effective at getting rid of the hangover.

[Happy234]

If you take piracteam everyday its best not to drink regularly if at all. I prefer not drinking at all because what Ive read its just best not too.

[Bajeda]

There doesn't seem to be much research on the interaction between piracetam and alcohol published in English. Here are some abstracts I found, but unfortunately I couldn't obtain the pdfs.



Czarnecka E, Stanisławska E. (1983). The effect of piracetam on the central action of ethanol in mice and rabbits. Pharmacol Pharm. Nov-Dec; 35(6): 451-65.

The effect of piracetam on the central action of ethanol in mice and rabbits. The effect of combined single administration of ethanol and piracetam on the rabbit EEG and on locomotor activity and ethanol sleep in mice was investigated. In addition, the effect of prolonged administration of piracetam together with ethanol on rabbit EEG and after-discharges evoked by electrical stimulation of the hippocampus was studied. The blood ethanol concentrations were also monitored. Single administration of piracetam did not change the effects of ethanol, while when given prolongly with ethanol piracetam attenuated the effects of ethanol. Piracetam did not affect the ethanol blood level.



Serby M, Segarnick DJ, Cordasco DM, Rotrosen J. (1982). Piracetam reduces alcohol withdrawal in mice without potentiating alcohol sedative effects. Alcohol Clin Exp Res. 6(4):520-2.



Dienel A, Andreas K, Schmidt J. (1985). Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility. Biomed Biochim Acta. 44(5):767-71.

The influence of several nootropic drugs (piracetam, pyritinol, meclofenoxat, methylglucamine orotate (MGO) and dihydroergotoxine (DHET) on both the ethanol preference and the enhanced seizure susceptibility after a single dose of ethanol was studied. Piracetam, MGO and DHET reduce the ethanol drinking in ethanol-preferring mice. The enhanced seizure susceptibility after a single dose of ethanol was abolished by piracetam and MGO.



Perfilova VN, Tiurenkov IN, Berestovitskaia VM, Vasil'eva OS. (2006). [Cardioprotective effect of GABA derivatives in acute alcohol intoxication]. Eksp Klin Farmakol. 69(4):23-7. [Article in Russian]

Cardioprotective properties of GABA analogs under conditions of acute alcoholic intoxication have been studied using the following functional tests: volume loads, tests for adrenoreactivity, and maximum isometric load. The experiments showed that a 32% aqueous ethanol solution intraperitoneally injected in a dose of 8 g/kg produces a cardiotoxic action, which is manifested by a decrease in the inotropic reserve in load tests. Citrocard (50 mg/kg), phenibut (50 mg/kg), and piracetam (200 mg/kg) prevent the alcohol-induced myocardium injury, as shown by the heart contractility retained on a higher level in the test group than in the control group.



Vikhliaev IuI, Artemenko GN, Voronina TA, Ul'ianova OV, Nerobkova LN. (1979). [Effect of piracetam on some manifestations of the effects of ethanol and acetaldehyde]. Farmakol Toksikol. 42(1):76-81. [Article in Russian]

An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex. Pyracetam also attenuated some toxic symptoms of acetaldehyde in mice. It shortened the duration of coma, lessened the intensity of convulsive seizures, but it had no influence on the lethal effect of acetaldehyde. The type of the relation between doses and effects suggests the observed antagonism to be of a nonspecific nature.

Reputation Comments on this post:

Excellent research, thanks.

[omega3]

I am writing this as a warning to people that mixing PIRACETAM AND ALCOHOL CAN DAMAGE YOUR STOMACH!

A year ago I was taking high doses of Piracetam whilst drinking alcohol at the same time, as a way to keep my mind alert whilst being drunk. However this resulted in me taking several tabs of the drug during the course of a night ontop of a stomach full of beer.

At first this was ok, but the problem was that I did this chronically over a number of months until suddenly I started waking up in the morning with a gnawing hunger feeling that would only go away temporarily when I ate something; basically I would always feel hungry, and it was an uncomfortable, starving feeling that wasnt pleasant at all! So I would be constantly snacking through out the day with little relief. If I didnt drink alcohol, it would be less intense, but still noticable. Also if I ate anything that was saturated oil heavy or chemically based such as caffine or sunflower oil, it would irriate it further.

Eventually I got to see a GP about this and I was told that I possibly had gastritis. I was proscribed the proton pump inhibitor medication called 'Omeprazole', which basically made my stomach produce more acid, and luckily, it went away almost over night, although I have an apiontment with a Gastroenterologist next month to check if I have developed an ulcer.

I went through months of discomfort however, hoping it would mend itself, but it didnt, and I can only link the onset of this from mixing large amounts of alcohol with large amounts of Piracetam..So if you are thinking of, or doing this..please be warned of what could happen.

[Happy234]

Originally Posted by betsym

Well, one can drink more alcohol without getting sleepy or drunk on Adderall and since Piracetam potentiates stimulants, increasing their effects, it makes sense that the same would hold true for Piracetam as well and swim has fround that to be true. However, caution should be used when combining Piracetam with alcohol or Adderall because one doesn't get the usual symptoms of getting drunk and so can become really smashed before realizing it. Piracetam can often cause a headache unless taken with Lecithin. Increased blood flow to the brain is responsible for this swim remembers reading somewhere.

always take a high dose of Lecithin (PS) with Piracetam. 10 grams per day

[Euphoric]

Originally Posted by Happy234

always take a high dose of Lecithin (PS) with Piracetam. 10 grams per day

This sounds unnecessarily excessive to me. I have 1 glass of soy milk a day, roughly, and when I don't have that I take 1gm of Lecithin, and I never headaches due to piracetam.

But lets keep this thread on topic and save that sort of stuff for the Piracetam info thread, please.