Combinations - MDMA and 2-CI cross tolerance

[wikiwahwah]

Hello

SWIM is off to a pystrance festival soon and is intending to take 2-ci and mdma. Does anyone know if there is a cross tolerance with these drugs? SWIM is thinking of taking the 2-ci on the first day and the mdma on the next, but is concerned the mdma will have little or no effect due to the fact that both are Phenethylamines.

Regards

W

[RaverHippie]

SWIM isn't sure if there is a correlation but he had taken 2C-T-2 during the daytime once then spontaneously ended up at a rave and tried to take some MDMA but it failed to give almost any effects whatsoever, thus, a tolerance effect. So it's possible., but then again there are an abundance of reports citing the great combination of 2C-B and MDMA so not really sure what SWIM is getting at, at this point. lol

[Shampoo]

There has not been any cross-tolerance reported between MDMA and psychedelics that target the 5-HT-2 receptor subtypes like LSD and 2C-I. I haven't seen any anecdotal reports (other than the one above) of a direct cross-tolerance between any of the 2Cs and MDMA, though few people take them in the same day at separate times. There are reports of combinations, in which both of the drugs seem to be potentiated. One friend of mine has reported taking 2C-B one day and MDMA the next without having any diminished effects.

Please come back and report when your friend has returned!

[wikiwahwah]

Hello,

Thanks for the replies, it looks as if the 2-ci shouldn't dimish the effects of the mdma too much - hopefully SWIM have a blinder on both days!!

W

[fonogoodreason]

Originally Posted by RaverHippie

SWIM isn't sure if there is a correlation but he had taken 2C-T-2 during the daytime once then spontaneously ended up at a rave and tried to take some MDMA but it failed to give almost any effects whatsoever, thus, a tolerance effect. So it's possible., but then again there are an abundance of reports citing the great combination of 2C-B and MDMA so not really sure what SWIM is getting at, at this point. lol

2C-T-2, (def and 7), and all the 2C-T-* (i think), are MAOI inhibiters. Meaning taking mdma, or many other drugs is a very poor idea. Taking mdma could lead to serotonin syndrome or death.

[RaverHippie]

Originally Posted by RaverHippie

SWIM isn't sure if there is a correlation but he had taken 2C-T-2 during the daytime once then spontaneously ended up at a rave and tried to take some MDMA but it failed to give almost any effects whatsoever, thus, a tolerance effect. So it's possible., but then again there are an abundance of reports citing the great combination of 2C-B and MDMA so not really sure what SWIM is getting at, at this point. lol

The reported feelings could have easily been caused by lackluster capsules of MDMA powder.

(slightly offtopic)

2C-T-2 was safely consumed in conjunction with MDMA on a number of occasions with nothing but positive reviews. I'm pretty sure it was speculated not proven to be an MAOI.

No experiences with 2C-T-7 to vouch for the MAOI status though. I've warned many about it though.

[Panthers007]

Last Known Sighting Dept: The 2-CT molecules MAY be MAOI. But we don't know. Tread lightly and carefully all SWIMmers. This is why these are RESEARCH chemicals. No provable data exists.

[researchbishop]

SWIM thought to post here rather then start a new thread as the question is very similar to the OP.

SWIM recently returned from a festival where he optimistically tried to roll on two consecutive nights, with fairly predictable results, ie no roll on the second night, swim could feel himself coming up but never got there, luckily he had the good sense to not chase it by re-dosing and quickly changed back to his old friend cider.

To try to stop this happening again swim researched alternatives, and happened upon the research chemical 2C-I and thought this could be an interesting alternative, and was planning thus:

Day one:
AM: A few ciders
PM: Rolling on MDMA, somewhere between 125 - 250gm

Day two:
AM: Sleeping
Midday: 15 - 20mg of 2-CI (dosage yet to be researched in the field)
PM: Cider

Day three:
AM: Sleeping
PM: Rolling on MDMA, somewhere between 250 - 500gm

Day three should be the BIG night and thus SWIM does not want to screw it up, has anyone any experience with this, is there a cross tolerance between the two, will the 2-CI, stop the roll on day three?

NOTE: SWIM very rarely takes anything, so would likely go into this after at least 3 months of rest from everything, er except the cider obviously, love cider.

[Dr. Satan]

Swim have already combined several times mdma and 2C-xxx (2C-I, 2C-B, 2C-T-2, 2C-E) never had the slightest loss of effects.
But, after numerous experiences, swim prefer to use them separately.

[Visionbird]

Originally Posted by researchbishop

PM: Rolling on MDMA, somewhere between 250 - 500gm

500 grams of MDMA is almost certain to be lethal

[Sameria]

Originally Posted by Visionbird

500 grams of MDMA is almost certain to be lethal

Absolutely. The LD50 for MDMA is predicted to be around 8grams in a full grown human. SWIM would not like to see someone after ingesting half a kilo of pure MDMA!

[researchbishop]

Originally Posted by researchbishop

SWIM thought to post here rather then start a new thread as the question is very similar to the OP.

SWIM recently returned from a festival where he optimistically tried to roll on two consecutive nights, with fairly predictable results, ie no roll on the second night, swim could feel himself coming up but never got there, luckily he had the good sense to not chase it by re-dosing and quickly changed back to his old friend cider.

To try to stop this happening again swim researched alternatives, and happened upon the research chemical 2C-I and thought this could be an interesting alternative, and was planning thus:

Day one:
AM: A few ciders
PM: Rolling on MDMA, somewhere between 125 - 250gm

Day two:
AM: Sleeping
Midday: 15 - 20mg of 2-CI (dosage yet to be researched in the field)
PM: Cider

Day three:
AM: Sleeping
PM: Rolling on MDMA, somewhere between 250 - 500gm

Day three should be the BIG night and thus SWIM does not want to screw it up, has anyone any experience with this, is there a cross tolerance between the two, will the 2-CI, stop the roll on day three?

NOTE: SWIM very rarely takes anything, so would likely go into this after at least 3 months of rest from everything, er except the cider obviously, love cider.

Since this previous post, well spotted peeps the gm mg substitution, just checking you were paying attention. You will never guess what happened, it seems ludicious, perhaps it is fate, but....

I was round the back of circle K again, and I found another report, I can not vouch for its authenticity, obviously from a researcher, trying to research the limits of cross torrence and possible sertonin burnout. I post it here in case it may be of interest:

Weight:180lbs
Gender: Male
Dose:
2C-T-7: 20mg 30mg
MDMA: approx 160mg
Mephedrone: 2gm
Methylone: 0.5gm
Route of ingestion: Parachuted, a little Insufflated
Setting: Music Festival
Main effects: Empathy, Music appreciation, a little introspection, (annoyingly), body buzz, tactile increase
Side effects :Some jaw tension, unsteadiness, on redose eye wiggles, (I love eye wiggles though)


2C-T-7, MDMA, Mephedrone, Methylone Report.

Friday

12.00pm 20 mg of 2C-T-7 parachuted, expected 2 hour come up, nausea and sometimes actual sickness is reported by users, I am well ahead of the game and also take two motion sickness pills. At about 60 minutes in legs feel heavy and tingly go for a walk, 90 minutes in feel a bit nauseous not to bad, passes quickly. Approx 2 hours in interesting cloud patterning, three dragons, breathing cloud fire, very relaxing if my mate would shut the fuck up, threshold dosage as intended without relaxing and and easing out the effects non are present, carry on for maybe 90 minutes, then we leave for elsewhere effects not noticed again.

Appox 12 pm one XTC pill taken, of known quality contain between, 80- 120mg of MDMA, no/little effect, one hour later another pill taken, this hits the spot, I am off this fecking planet the rest of the night the most intense rolling to date, great music 2manyDJs, and fantastic sexy company is also found, makes for a near perfect night, fecking awesome, this is why we do this, brilliant. Okay I had a good night, I will shut up about it now. To be honest the pill had too much speedness in it for me, this gave us a wasted out crash at about 4am, this was true for my new best friend ever, did I mention her? (she had one of the same pills). The point is we were both very groggy in the morning finding it hard to converse. I was worried the next day, we had just "come up at the same time" and did not have as much in common as I had thought, as it transpired this was not the case and we spent the next day together, on nothing more than cider!! Anyway...

04.00am totally burned out and wasted, escort new friend back to tipi, hit sack, sack does not seem to mind.

Saturday

01.00pm 30mg of 2C-T-7 parachuted, higher dose than yesterday, expected to be needed because of tolerance, which is now likely, and possible serotonin burnout, also take three motion sickness pills, no effects at all after 2-3-4 hours, by this time down in the festival proper in our favourite bar, lounging on beds in the sun, nearly 5 hours now, in fact I am so sure nothing is happening I have stopped timing, in the queue for the toilets and the entire front row of loos, is breathing and pulsating, wow everything is vibrating man, again threshold effects which can be turned off with a blink, back at the bar, the vibrating feeling is back with some heavy bass from the stage, and the bar sign is going mental, I find myself grinning like a hippy, probably not a good look, so I keep pulling myself back, which was probably a shame, also had some introspective thoughts, not a good time to have these annoying, this all wears of at some point in the evening.

09.00pm-04.00am Manage to get the high back rolling on legal MDMA analogues, namely mephedrone, two 250mg doses parachuted approx, 2 hours apart and for the grand finale 250mg railed at approx midnight, a real head shaking eye wobbling freight train hitting, experience, but in a good way.

Sunday

Relaxing day time, shockingly only cider consumed. (With the ridiculously vivacious and attractive girl, I may have mentioned her) This is the real test can we do three nights rolling, we will just get side effects, will anything work, drugs of choice are MDMA analogues mephedrone and Methylone.

06.00pm New best friend has to leave early, fecking gutted

09.00pm 300mg of mephedrone and methylone parachuted, (combined weight), fuck I and totally back in the game very surprised, pumping tunes going mental all as the previous night, although not as good as the MDMA night, obviously.

11.00pm re-dose with 350mg of the same, not quite getting there now but still very good, a little unsteady on feet, and must be maxing out now.

12.30am last re-dose, just for research purposes now, 350mg taken again, all this does is bring back the unsteadiness which had passed, but worst, manage to keep moving though will power for no reason, should have just sat down, remembering venue shuts down at 01.00am on the Sunday in any case. Back to the tents, for a chill out, until about 04.00am, I am shattered, go straight to sleep, concerned about possible huge crash in the morning.

Monday
06.30am Get up, feeling tired but no other effects, packed up and off site by 08.00am.

All in all very rewarding and worthwhile research, very surprised by the amount it was possible to push it on a one off.