Combinations - Salvia Divinorum (dissociative) and Percocet (opioid)

[Richi]

Oxycodone and other opioids are opioid receptor agonists designed primarily to relieve pain. One common side effect is the strange but mild hallucinations some people have while taking opioid medications such as Percocet. Salvinorin A is a potent selective kappa opioid receptor agonist, inducing hallucinations by acting on this receptor.

See where I'm going...

Taking Percocet would stimulate some of the k-o. receptors, followed by smoking Salvia divinorum might result in a synergistic effect. Reaching a Salvia 'breakthrough' would theoretically be easier and faster, and possibly more intense, if one were taking opioid medications beforehand.