Combinations - Salvia Divinorum (dissociative) and Percocet (opioid)

[Richi]

Oxycodone and other opioids are opioid receptor agonists designed primarily to relieve pain. One common side effect is the strange but mild hallucinations some people have while taking opioid medications such as Percocet. Salvinorin A is a potent selective kappa opioid receptor agonist, inducing hallucinations by acting on this receptor.

See where I'm going...

Taking Percocet would stimulate some of the k-o. receptors, followed by smoking salvia divinorum might result in a synergistic effect. Reaching a salvia 'breakthrough' would theoretically be easier and faster, and possibly more intense, if one were taking opioid medications beforehand.

[bcubed]

Lizard has thought along the same lines; the concern he would have is if there is a synergistic effect for the more "traditional" opiate effects, as this could be dangerous.

As salvia isn't lethal of its own accord, it "shouldn't" be a factor, but lizard feels it to be better safe than sorry, and advises a very incremental approach to exploring this...

[drug-bot]

swims on 80mg of methadone(full mu agonist) daily and wants to smoke salvia again, as its been a long while (before he was an opiate addict), any thoughts as to the safety of this? any one attemp this (on any dose of methadone)?

[RaverHippie]

SWIM will be testing this out when he wakes up tomorrow. He told me he's going to ingest the last of his hydrocodone (20mg) and then smoke salvia once the full opiate effects have set in. I'll make sure that he remembers to type up a trip report about the whole experience after it's all over and he'll probably mention it again in this thread as well.

[fiveleggedrat]

Swim only has a gram of 20x extract left, and possibly might use it under the influence of strong opiates to see what happens

It'd be nice if some altogether different effects happened.

[Richi]

If anyone has any more information or a TR to add, it would be very much appreciated.

[static_vodka_420]

swims tryed this before he says its much easier to break though into salvia world and a little less frightening. he smoked 1 hit of 60x and was spinning through dimensions melting into his couch with addition of 40mg oxycodone whereas normally it would take him 3-4 hits to reach that area. swim will right a more detailed report on this later but hes just verifying your question at the moment

Reputation Comments on this post:

	thanks for searching and posting, more information on this topic is very helpful
	Good to know. Would love to see the full trip report.

[Maxfrombx]

SWIM's friend took 2g of UEI 2H before smoking salvia (x5 extract). His trip was intense and long, then he got sick as hell for 24H. Don't know if it would be transposable to other opioids though.

[EDIT on demand]: UEI > Ultra Enhanced Indo.

SWIM's friend was opiate naive. 2g of UEI made him more sociable and euphoric. After him begging SWIM to try salvia, which was not a good idea in SWIM's opinion, SWIM let him give it a go. As stated before, he tripped hard and long. No anxiety. He could see thousands of flaps like SWIM's one, following each others at the rate of one leafing pages through a book, and had to grab the electric cable of a lamp to be sure to stay in SWIM's one. SWIm filmed the whole scene and he was amazed to realise he had no recollection of any of this. Anyway, that's quite common with salvia.

SWIM told him "You'll laugh in 15 min watching yourself on video and having no recollection", but the trip didn't end. The friend finally collapsed in SWIM's bathroom, and after 1H30, he was coherent again, although white as a blanket and puking 3 times. He was sick all the day/night after. Maybe because he was opiate naive.

Anyway, mu agonists seems to lenghten the kappa trip of salvia, and maybe lower the anxiety that goes with it. SWIM wonders what it would do with benzos or any A/B gabaergics.

P.S: sorry for the approximate translation from mother-language.

[CoryInJapan]

Well all swim can put in on this is that He Did DXM(semi-synthetic Opiod) DOnt know what receptors it triggers. Swim can say though that while on DXM when he smoked Salvia 15x on it he had an instant Breakthrough experience..Imediately Transported into hyper space. Also Since he was tripping on DXM the Salvia didnt give him the shock he usually gets when doing it sober.