Combinations - Salvia Divinorum (dissociative) and Percocet (opioid)

[Richi]

Oxycodone and other opioids are opioid receptor agonists designed primarily to relieve pain. One common side effect is the strange but mild hallucinations some people have while taking opioid medications such as Percocet. Salvinorin A is a potent selective kappa opioid receptor agonist, inducing hallucinations by acting on this receptor.

See where I'm going...

Taking Percocet would stimulate some of the k-o. receptors, followed by smoking salvia divinorum might result in a synergistic effect. Reaching a salvia 'breakthrough' would theoretically be easier and faster, and possibly more intense, if one were taking opioid medications beforehand.

[bcubed]

Lizard has thought along the same lines; the concern he would have is if there is a synergistic effect for the more "traditional" opiate effects, as this could be dangerous.

As salvia isn't lethal of its own accord, it "shouldn't" be a factor, but lizard feels it to be better safe than sorry, and advises a very incremental approach to exploring this...

[drug-bot]

swims on 80mg of methadone(full mu agonist) daily and wants to smoke salvia again, as its been a long while (before he was an opiate addict), any thoughts as to the safety of this? any one attemp this (on any dose of methadone)?

[RaverHippie]

SWIM will be testing this out when he wakes up tomorrow. He told me he's going to ingest the last of his hydrocodone (20mg) and then smoke salvia once the full opiate effects have set in. I'll make sure that he remembers to type up a trip report about the whole experience after it's all over and he'll probably mention it again in this thread as well.

[fiveleggedrat]

Swim only has a gram of 20x extract left, and possibly might use it under the influence of strong opiates to see what happens

It'd be nice if some altogether different effects happened.

[Richi]

If anyone has any more information or a TR to add, it would be very much appreciated.