Combinations - Lsd and maoi

[Capita]

Swim was wondering if you combined a maoi and lsd would the effects of the lsd be stronger?? How ofter and when do you eat the maoi?

[Ontherooftops]

Why would anyone want to do this? Usually maoi and psychedelic combinations are much more dangerous than the psychedelic alone. This is certainly true with a drug like LSD, which is pretty darn safe on its own.

Its not like LSD isn't mind bending enough...

To each his own though I suppose. A proper MAOI diet would have to be undertaken for a few days prior to the experience, it would be advisable for a sitter to be present. It would probably work much like with DMT and other tryptamines, i'm sure the information on MAOI potentiation is readily available, do the research and be safe.

Better yet, if the LSD isn't strong enough for your lab rat, why not just give the lab rat more lsd?

[ODB]

I think its a good question. I would like to know how safe it is as well. I take P.Harmala seeds as an anti depressant and have a few tabs laying around some place. It would be good to know if they will be safe or if I should stop taking them 48hrs prior to a trip.

[Capita]

Originally Posted by Ontherooftops

Why would anyone want to do this? Usually maoi and psychedelic combinations are much more dangerous than the psychedelic alone. This is certainly true with a drug like LSD, which is pretty darn safe on its own.

Its not like LSD isn't mind bending enough...

To each his own though I suppose. A proper MAOI diet would have to be undertaken for a few days prior to the experience, it would be advisable for a sitter to be present. It would probably work much like with DMT and other tryptamines, i'm sure the information on MAOI potentiation is readily available, do the research and be safe.

Better yet, if the LSD isn't strong enough for your lab rat, why not just give the lab rat more lsd?

Swim knows the dangers of maoi's but swim is unable to get more lsd so swim wanted to get the most effects of lsd with the smallest amount

[Shampoo]

Originally Posted by Ontherooftops

Why would anyone want to do this? Usually maoi and psychedelic combinations are much more dangerous than the psychedelic alone.

Is this a statement in reference to the MAOI dietary restrictions? or about the potential for more intense emotionally oriented psychedelic effects? Please explain with this is 'dangerous'.

Better yet, if the LSD isn't strong enough for your lab rat, why not just give the lab rat more lsd?

This question has been asked before, and this answer has been given before, but it fails to answer the question. Couldn't that be a potential answer to every (or most) question regarding potentiation?

LSD is a controlled substance, and thus is not readily available in unlimited quantities to most users. Potentiation is a perfectly valid query, and should be answered as such.

That being said, I dont have much of an answer for you. All I can offer can be found easily by using major internet search engines. Some reports say that the effects of LSD are diminished by the use of MAOIs*, others say that they are potentiated. As always with a new combination, start low and slow, and keep a strictly tyramine-free diet. Please report if your friend does decide to go through with this combination.

* http://www.erowid.org/chemicals/maois/maois_info4.shtml

MONOAMINE OXIDASE INHIBITOR:
*Phenelzine* (Nardil) -- decrease in response to LSD

Nardil is non-selective, while the harmala alkaloids are selective, I believe for MAO-A inhibition, so there could be some difference...

Another potential warning, MAOIs seem to have a very tumultuous relationship with amphetamines that has resulted in very negative side effects including death. Some blotters that are sold as LSD actually have DOx molecules on them, which are substituted psychedelic amphetamines, and which could have an equally negative reaction with MAOIs as MDMA. If your monkey/friend does decide to experiment with this combination, they should make sure they have a very reliable source for real LSD.

[Ontherooftops]

Is this a statement in reference to the MAOI dietary restrictions? or about the potential for more intense emotionally oriented psychedelic effects? Please explain with this is 'dangerous'.

A bit of both. Potentiation of any drug leads to less control over its effects in general in swims opinion. In trying to get the most possible out of a smaller amount it makes some sense. The dietary MAOI restrictions certainly pose a threat, and these combinations are not well tested, to swim's knowledge, and could result in unforseen effects.

As well, for swim, LSD is a beautiful drug at any dose, being able to appreciate its effects in small amounts is just as worthwhile as full blown psychedelic experiences.

Swim has known a few people experimenting with potentiating psychedelics other than DMT with an oral MAOI. It seems to work for many substances, but from what he's seen, often results in an experience which is much less recreational and more an intensly introspective session.

Taking the MAOI an hour before the psychedelic is ingested seems to be the standard practice.