Combinations - Loperamide: Good codeine potentiator?

[Tortoise]

Hi folks, Swim is a regular user of codeine who has recently discovered a way to potentiate codeine that he has not read about before.

Usually Swim takes some promethazine (say 25mg to 50mg) about half an hour before ingesting the codeine (preferably on an empty stomach but today and yesterday he also took about 2mg of loperamide (immodium) approximately one hour before the codeine and wow! The results were wonderful, it really enhanced the experience.

Of course, this is probably not particularly wise to do all that often as constipation isn't that much fun.

[fiveleggedrat]

Swim has a large amount of loperamide around that he's been meaning to experiment with solo, like an idiot, but has recently gotten hold of a decent amount of T3's. He will experiment with this and get back. It makes sense that it would potentiate too.

Swim also has huge amounts of tramadol, and uses with pot (at different times, because the two sadly do not work together well) as his main two drugs.

Swim theorizes tramadol + loperamide as having a good effect, and tramadol has not been the same for swim for about a year, it got really boring, lost the euphoria/sedation almost all the time.

[fiveleggedrat]

Swim says 4mg loperamide made his tramadol much more physically sedating, his breathing was noticeably deeper and slower. Stronger CNS depression, but at the same time, less euphoria/contentment, but that could just be him.

[Stephenwolf]

This could work as a potentiator because even though Loperamide doesn't cross the bbb it does still bind to OTHER opiate receptors in the body, if most of the Gut receptors are full then in theory less codeine would fill gut receptors and would be able to fill more of the Brain ones. a similar idea was given by a guy talking about trying Loperamide to potentiate an endorphin rush.... it sounds possible....

Reputation Comments on this post:

Great Info

[Tortoise]

Originally Posted by Stephenwolf

This could work as a potentiator because even though Loperamide doesn't cross the bbb it does still bind to OTHER opiate receptors in the body, if most of the Gut receptors are full then in theory less codeine would fill gut receptors and would be able to fill more of the Brain ones. a similar idea was given by a guy talking about trying Loperamide to potentiate an endorphin rush.... it sounds possible....

Yep that's Swim's theory too. Check out my other post in the "Saving money by potentiating opiates" thread.

[0utrider]

DXM seems to be a better potentiator, but a little loperamide seems to work as well.. 1 loperamide, 1-2 dxm (max 60mg) and a lil GFJ makes a good potentatiors stack (even though GFJ is not good for potentiating codeine)

[Tortoise]

Swim has never noticed any improvement to his codeine high after taking DXM...

[fiveleggedrat]

Swim has recently given up on most potentiators. Swim says that he just can't be sure if they are working, and it really drives Swim nuts taking so many things and still feeling like it does not help. Swim sometimes is almost sure that he is getting less euphoria when he takes potentiators.

Swim takes GFJ, Quercetin, Calcium Carbonate, Naproxen, and many more Swim can't think of. Swim will stop using them all for a long time, and start doing more in-depth experiements with them all after a bit.


Anyways, back on loperamide, Swim will test loperamide more often with opiates. Swim has high hopes ready some other posts here.

[Sportsguy86]

all placebo effect if anything. immodium does not cross the BBB. ive never tried to get high off it because i think that is so s*ck. trying to get high off otc anti-diarhhea pills, doesnt get any more pathetic than that.

what it can do, however, is in large doses it can alleviate minor opiate withdrawal. and it doesnt just get rid of the runs...it helps with everything. if youre ever in a situation where you have a very small dependence and experience hot/cold sensations, minor achiness and fatigue--take at least 12mg+ (6 pills) and wait about 1:30 to 2 hours. it should almost entirely get rid of the physical symptoms. the more you take the better probably but you also want to be able to sh*t sometime in the near future so dont overdo it. if you 12-16mg doesnt help much than up the dose. read stories of people wiyh bad opiate withdrawal, taking 150mg of loperamide with a benzo and literally destroying all symptoms.

Reputation Comments on this post:

c'mon man, think before you type

[Tortoise]

Sportsguy, nobody's saying that loperamide gets you high, we're suggesting that it may potentiate codeine. Swim stumbled across this accidentally recently when he had gastro and took some codeine for fun. Read Stephenwolf's post above - he has a very viable theory on the subject.

[fiveleggedrat]

Swim posted this a while back in other threads, but the loperamide, when mixed with other opioids, VERY noticeably increases CNS depression and slows breathing. Opioids tested with include codeine, hydrocodone, and tramadol.

Definately something to keep an eye out for.

We don't need someone dying because they mixed the two and had too much overall.

[darkglobe]

Originally Posted by Tortoise

Hi folks, Swim is a regular user of codeine who has recently discovered a way to potentiate codeine that he has not read about before.

Usually Swim takes some promethazine (say 25mg to 50mg) about half an hour before ingesting the codeine (preferably on an empty stomach but today and yesterday he also took about 2mg of loperamide (immodium) approximately one hour before the codeine and wow! The results were wonderful, it really enhanced the experience.

Of course, this is probably not particularly wise to do all that often as constipation isn't that much fun.

I was under the impression that Loperamide, although a form of Opioid, does not cross the blood-brain barrier, and theoretically should make no difference to the effect of SWIY's Codeine use.

Although - I did read on www.opioids.com (a site I personally believe to be very inaccurate) that Loperamide may compliment the effects of Codeine.

There's a thread on DF about this, you could try searching. Was a hefty thread tho!

EDIT: Shoulda read the whole thread, lol. Stephenwolf's theory may well be plausible, although I'm not aware of gut receptors, but I'm not a medical professional... All I know is it does not cross the BBB, and as far as I was aware, would not potentiate Codeine.

[RoboCodeine7610]

a couple days ago SWIM saw SWIT's post and decided to give it a try, so he did a CWE with 160mg of codeine (probably yielded about 135mg) and took 4mg of loperamide 20 minutes before taking the codeine and noticed absolutely no change at all. in SWIM's opinion it makes no difference at all (exept with the constipation).

[fiveleggedrat]

I'll sum up Swim's previous posts:

Loperamide only increases CNS effects, including physical sedation. This is not a positve, really, and gut motility goes all to hell. Constipation for next few days at least.

This is in regards to decent doses, above 10+mg.

Anything lower than 8mg will not have a noticeable effect.

There really is no point in adding loperamide unless you want to suffocate. Swim experimented with it plenty.

Swim combined up to 20+mg solo and with other opioids. Same thing with all, CNS sedation. Read: No euphoria or otherwise POSITIVE benefit.