Smoking - Cannabis-Storing up THC in system-Help plz!

[MingChies]

Hi, I am just looking for some advice on smoking. SWIM has been smoking weed for about three years. SWIM thought he was doing everything right until one of SWIM's friends brought up the idea that SWIM might be storing up the THC in his system instead of using it to add to SWIM's current high. SWIM would like not to store it up because all it does is sit in your fat cells and accumulate until you have to do a drug test and thats where you get fucked. Any tips from experienced smokers? Anything would be greatly appreciated

[Inudiablo]

Of course it will add up. Being as THC binds to fat. But if Swiy was really worried about this. Merely stop smoking for about 3 months and your piss should be clean. As for not adding to the high. Smoking more will get you higher (Plain out) and Swiy tolerance (To Swim's knowledge) Has nothing to do with the thc bound to the fat. But the brains tolerance. One thing Swiy might do is to drink De-Tox drinks often. As this cleans out Ones blood and urine. Another thing is if Swiy is going to have a drug test in say... a week. Drink Large amounts of water and exercise. THC will come out of your system when you work out being as the fat that it is bound to is used. Also try chilling in sauna's. As they open your pours and make you sweat. Thus lowering the about of THC built up in your system.

[Shampoo]

Tolerance to cannabinoids has nothing to do with the THC that remains in lipids deposits in the body. Most of the 'THC' that is stored in lipids is THC-COOH, the inactive metabolite used for detection in drug-tests. Active THC has minimal non-specific binding, which is immediately released when ng/ml reach a certain lower-end threshold, meaning that as the active THC leaves the blood, the 'stored' (depot-bound) THC is released to prolong activity. This happens with many psychoactives that have a propensity towards non-specific binding. Bottom line, your friend is not losing active THC (and thus not losing 'high') to lipid deposits in their body. They are losing the 'high' to downregulation of CB receptors, an phenomenon that occurs mostly in the brain, but also in other parts of the body, accounting for what is known as 'tolerance'. There is a stickied thread in the cana-forums explaining tolerance, if your friend is interested.

[MingChies]

Thank you both very much. I will look at the thread as it does seem interesting.