My cat has been taking benzodiazepines medicinally to treat panic disorder/agoraphobia/avoidant personality disorder kind of deal for a number of years now. She does not typically drink alcohol
; but, she's used morphine
in the form of opiums and/or pharmaceuticals for a number of years as well.
From her experience, the best way to potentiate benzodiazepines (in specific, lorazepam
because it contains all of the benzodiazepine
effects, which makes it her favorite) is to take 2-6mg, depending on the situation (I will further add that this is JUST her medicinal dose and everyone has their own dose due to tolerance etc.), and place the SL tablets under the tongue. She then will proceed to place an alcohol underneath the tongue to quicken the dissolve and therefor absorption because benzodiazepines are typically freely soluble in alcohol, more soluble than in saliva.
She would then consume one 7% beer or its equivalence to aid the CNS depressant effect.
She always takes 100-200mg dimenhydrinate or 50-100mg diphenhydramine
(diphenhydramine in its own is 2-fold more potent because dimenhydrinate has to be broken down into diphenhydramine in the liver, but I digress) whilst taking benzodiazepines.
This is her medicinal ritual for high anxiety/panic situations.
Recreational would, typically, be a higher dosage of benzodiazepine with a similar dosage of potentiators. 6-10mg works fine for her personal situation.
When adding opiates
to the brew, one would be wise to reduce all doses and maybe even dose respond. 30-60mg codeine
seems to work fine with around 150mg dimenhydrinate, 6mg lorazepam kind of doses for her.
The addition of grapefruit never hurts as it inhibits CYP3A4 which is responsible for the breaking down of many benzodiazepines, as well as dextromethorphan
, opiates, psilocybin
, and some other drugs
I hope this has shed some light on the idea of benzodiazepine potentiation. Ativan
is used intrabuccally because saliva is not only water therefor the water solubility of Ativan does not matter here, especially since one is probably swallowing the remaining chemicals left in the saliva after the hour or so that they might let it absorb for.
Have an excellent evening, be safe when medicating, thank you.
I further add in retrospect that it is of course not recommended to mix CNS depressants
and such actions should not be taken unless one is sure of their bodily reaction and even then it is dangerous business to step into. Safety before any thing else.