Big News! First Street Use Of Opioid Peptides!!!

[Handle]

This is big people! Think opioid peptides, beta-endorphin, endomorphin-1 and 2.

This could be the first recorded street [non clinical] use of opioid peptides.
And here's the best part -it's not even illegal!

Nevertheless, it was my swim that did it. But I can honeslty admit that I was present for this momentous occasion [to say the least]

FACTS
Individual is a full time bupe [buprenorphine] addict, part time heroin addict/user.

He has had the peptides in his freezer for nearly a year.

He was coming off a half weight of hammer, trying to get back into the groove of drudgery and degradation living without mu stimulation.

He had actually had more than his fair share of bupe that day, so the whole experiment seemed like a big mistake.

TIMEIt was about 11 at night, he was bored. He had never had his peptides before because he was told they were centrally active only.

The line was that the ol' BBB [blood brain barrier] would not allow endorphins to pass. He believed this. Didn't want to waste more than a ggrand's woith of good peptide on an unremitting membrane that would supposedly block all pleasure.

DOSE 5mg of endomorphin 1, 5 mg of endomorphin 2. They are said to be the most potent dopamine RELEASE agents known to nature, that's what I've heard. That lead to my theory that synth opioids cause sedation because they are a pale imitation of the real thing, which may in fact be stimulating.

Anyway, there is total agreement that they are powerful mu pumpers.
SWIM got 'em out of the freezer, and got his works ready. Metal spoon!
Had no saline so used freshly boiled kettle water. Let it cool in the fit to make sure the heat didn't damage the peptides.

Got the little vials out of the freezer. They were screwtop clear plastic.
I could see the very fine white substance withing, not a powder so much, morel like an ultra microfine filament structure, so light that it could not collapse under its own weight. It wafted freely from top to bottom of the vial when turned upside dwon. Fell out the open top into the metal spoon, where it assumed a more powder like texture, just like a tiny trace of real gear. It was only 5mg, but it looked like an Australian 50 bucks worth of good hammer. Nevertheless, it was clearly a small amount, and less dense than real gear powder.

Put in the water. It dissolved really well. It only left a tiny little white trace, sort of sticky at the bottom. The plunger was used to stir it in and get rid of the residue at the bottom.
Solution was clear and colourless, not cloudy at all. [The research peptide company website said they had good aqueous solubility]
Then swim had no cotton so he used the tip of a cotton bud, [Q-tip as you say] only a small filter was used as the solution was remarkably clear.

Swim primed up, tied off [something he doesn't normally bother with] because he didn't want any fuckups, like a nasty local mis-hit which could be very irritating as it was a peptide and not an alkaloid.
Who knows. Swim got a Fedex package that was full of warnings saying don't do this, don't do that, very explicitly saying it was not safe, don't use in clinical practice, effects are unknown, on and on, don't do it.

But it was 99.98% pure, and impurities were supposed to be free amino acids, calculated at the rate of breakdown in cold storage.
PS, swims freezer broke down a few moths ago, and for a couple of days the poor peptides were in filthy unsanitary conditions, certainly not at the right temp, but they have proven themselves durable, to say the least!

EFFECTSSwim slammed that baby ta hell, for various reasons
[like improper storage, his dose of bupe and that pesky BBB] he expected no effects at all. It all went in, and then there was a latency period.
Then BANG! there is nothing to compare it to. I say orgasm not because it was like an orgasm in intensity, but mainly in feeling, it was a very pure natural feeling. But also WAAAAAAAAAAAAAAAAAAAAAAYYYYY
too powerful, it caused a panic reaction. SWim raced to the bathroom, his pupils were HUGE. I repeat, it caused mydriasis, not miosis. And there was definite mental stimulation, but nothing like speed, nothing like coke. It was weird.
The opioid feeling was just so ridiculously strong, it was like a terrible pain, I suppose because that is the only other time we feel endo's like that is if we just severed a limb or something.
It was too strong. Unpleasant. Supposed to be powerful antitussives, these endomorphins nevertheless caused very rapid breathing, the type you can't conceal.
And panic. I can't stress enough, that the feeling, not in quality, but in that quantity, would make anyone panic, swim tells me.
Especially because he uses opiATES, that feeling is a prelude to a massive overdose and no more breathing, you do tend to panic a bit.
It lasted about two full minutes maximum, with seemingly no effects after that.

The combo of umpleasant hyper intensity and sudden onset and loss of effects make it perfect for intramuscular use IMHO, but it would need guarantees that you can't get a nasty infection from using it. And also, it could be very irritating, swim still doesn't know. He wasn't prepared to snort or taste even a little bit as the amounts involved are so tiny it was impractical.

SUMMARY Oh yes forgot to mention that the next morning he used 11mg's total peptide, including 1mg of beta endorphin, and swapped half of the last night's endo 1 for endo 2.
It might have been even stronger, certainly as strong. Swim is trying to get a hang of the effects, but they are ridiculously ovverpowering, and very stimulating, it's not your average opiate experience he tells me.

In all, the ONLY thing it has in common with alkaloidal opioids is the rush, which is fantastic. I have always craved a bit of hydro or oxy morphone, from the description it sounds great. But I raise this becauxse swim tells me that these effects would rival anything for a rush, crack, hammah, anything.

It is a truly strange experience to feel such an obvious opiate rush like that without the long lasting usual side effects. I think it lends credence to the idea that they really are stimulants.
Definitely would lower the dose though. Just too much to handle, the panic is no good. Too hard to get used to as well.

More info is on offer if anyone wants to know. My personal opinion is, I have taken part in, or at least witnessed, the making of junkie history. I believe this is the first street use of peptides, it's not even illegal yet, this deserves to go down in the annals of Burroughs/Thomson style extreme junkie folklore. It's also a medical marvel as it totally refutes the nonsense about the BBB, at least for endomorphins. Swim's big regret is that he piled in his only vial of beta endorphin into the same hit as the other stuff, because he has seen clear reports that it does not work IV, but needs to be ICV'd [nasty stuff, deep brain injection] and this might not be true.
I don't know why pain patients in the trials don't appreciate it, but this shit works.
Forget about the BBB.

Reputation Comments on this post:

	A groundbreaking report!
	H, you are indeed a trailblazer. Kudos!

[Panthers007]

Write it up again in a formal format. Very interesting. Very!

[fiveleggedrat]

Swim would love more info on the above, especially theory.

[Expat98]

After having experimented with a (different) research peptide a while back, SWIM knows that it takes guts (or maybe a little stupidity? - at least in SWIM's case) to inject something unknown and very potent into your body (subcutaneous in this case). SWIM will not be doing it again.

But it sounds like this one worked out well for you. Very interesting indeed - thanks for the groundbreaking report!

IMHO peptides are a very promising area of drug development with a lot of recreational potential (not to mention medical potential). I believe we'll be hearing a lot more about various peptides in the future.

Expat98 added 58 Minutes and 18 Seconds later...

By the way...in the interests of harm reduction and plain old common sense...wasn't mainlining 5mg of an unknown peptide for the first time you'd ever used it an extremely reckless thing to do?

With the peptide that SWIM used (bremelanotide) he began with 1mg, and that was subcutaneous, not IV. Glad you're still here to tell the tale.

[Paracelsus]

Very interesting, and I agree with Panthers that you really should invest some time into doing a good write-up. And use a more appropriate title, unless you live on da str33tz.

[DonPeyote]

SWIM tried IM'ing various opioid peptides about 5 years ago, so you aren't the first. My friend gave up on the opioid Peptides as they were too short acting and very expensive. They reminded him of Meperidine, which he disliked.

[Richi]

Handle did say that this is the first recorded non-clinical use opioid peptides... and thus far he is right, as no one has pulled up a post dated earlier than his.

On that note, does anyone know of any research available on the subject?

Particularly on the hypothesis stated by Handle, that opioids act as stimulants.

[Spare Chaynge]

what are opioid peptides?

[Richi]

Originally Posted by Spare Chaynge

what are opioid peptides?

Google will know...

[Spare Chaynge]

so if swim ate spinach he might feel better.

[Ontherooftops]

The buprenorphine could possibly alter it's effect. Subjects without bupe should also assay this substance.

[Panthers007]

Originally Posted by Ontherooftops

The buprenorphine could possibly alter it's effect. Subjects without bupe should also assay this substance.

For all we know having the buprenorphine aboard saved the monkey's life. This certainly wasn't a scientific assay by any stretch of the neurons. No - one shouldn't try this again at home, kids. This was an extremely reckless and foolhardy venture. I could see leaving a loaded syringe propped up in a certain individual's chair, but...oh never mind...

Reckless and foolhardy. But, nonetheless, very interesting.

[Handle]

I knew swim would have to face the reckless and foolhardy charge, ok, at least side effects would be unknown.
But these were synth peptides, using only aminos as building blocks, done unit by unit [they tell swim].

Done by an outfit on the us east coast, I don't want to be too specific because it may cause trouble for swim, but i will eventually scan in the empty containers and all that to show you, but swim will blot out the company, batch number etc. otherwise [swim knows] there will be a shitstorm.

Swim is prepared to wear the reckless charge, anything could have happened, including shock, allergic reaction and basically an overstimulation heart attack.
But swim figures that looking at a first for him at least, and knowing the everyday danger of heroin use, it was about average for the risks in his life.

Sorry about the egotistical self aggrandisemnt too folks, but swim was pret-ty 'up himself' about the whole thing.

But down to business, there is more to report.
Swim took a vial to an old friend [old man, not friends for long time] who knows his stuff. Told him all the risks, the FULL story [which has not been disclosed here, but there could be trouble about this in some quarters if this all gets back to swim] and the mate agreed to give it a go.
Swim ight have talked it up, but the old guy didn't rate it highly. He agreed the rush was strong, very overpowering and opiate like, but said he was too accustomed to heroin to move on.
I personally asked was it too short acting, he said "No, I can still feel it now as a matter of fact" and one can feel something up to fifteen minutes or more later, but it's more of an afterglow.

Anyway, the final verdict was "I wouldn't jump up and down about it" oh well.

Swim acted on his theory that intra muscular was the waaaaaaayyyy better way to go, and jabbed his ass! He reports that the move was a wise one, making the whole effect much easier to handle and resembling much better a conventional opiate effect. It also reduced or even removed the unexpected stimulation feeling, and of course had the advantage that it made it last a bit better, with a much smoother ride that lasted fifteen minutes at its peak.
He was on kava to though, deliberately, specifically to reduce the stimulation. But another IV hit on kava proved that it was not really the kava that rounded off the sharp edges, it is definitely the mode of delivery.

Swim also is pleased to note that it significantly reduces his opiate depression and pain for days, it's a mystery, and although the stuff is enjoyable and will run out, swim doesn't crave it nor does will he use it more than once in two days.

Also, the old guy said he particularly noticed a very strong opiate feeling in his legs, especially under the thigh, it might just be the power of suggestion but swim also later realised it did seem to feel particularly strong there. We are only just learning of discrete opiate receptors in different places, who knows eh?

Now panthers and para, about rewrites, you can PM me with a standard format and I'll give it a go as soon as I can, but thanks especially to Paracelsus for supporting my swim in his report, for many reasons he was tussling with whether or not he would go ahead with his claims, not sure how people would react, so thanks for supporting, if not he risks involved, at least the reporting, I did the best I could, but will have a go at suggestions for improving the thread starter.

And about being 'first', swim really did think he was first, but oh well. One of the first at least. At least he can stand by his claim that it's up there with the "live adrenal gland" or "the man within" stuff of tall stories and prophetic imaginations.

PS, doses were also subsequently halved. Swim says he would never have more than 5mg IV again, IM it's ok, but nobody needs that much of a rush. You need to lie down [that's what the old guy said "I'm gad you told me to sit down, there's no doubt it hits you hard"]

[Paracelsus]

I don't know of any standard format, but something resembling the entries in PIHKAL and TIHKAL would be suitable for better organization (i.e. a section of short experience summaries, with dose, substance, and route of administration, and a section of retrospective summary and commentary; if needed, split the latter into subtopics). It would simply be much more easily readable in such a way, especially for people who don't have the time to read 1246 words.

[Handle]

Oh, by the way, there ware two interesting afert-effect experiences I would like to report.

All of the first lot concerned doses that included some varying amount of endomorphin.

I must confess that i know very little about the substance except that it is a potent dopey-mean release agent. Well, anyway, after two separate experiences with it involved, there were two, mild but definitely not imagined, minor muscle tightness side effect experiences.

The first one was at night. After going to bed, swim had a definite experience of slight

tightness in the facial muscles around the forehead. It wasn't freaky or painful, it was not severe and didn't last long, but it was there, undeniable and very unusual [ie, not an experience that swim has ever normally had].

The next one was after a morning dose, he was in the shower, and suddenly got exactly the same slight tightness but this time it was in his right forearm, in the stringy muscles on the underside of the arm. Again, it was gone very quickly and caused no discomfort, but it was noticeable, and curious.

Swim on another occasion, rinsed out seven one milligram vials/"phials" [or whatever it is they're called] of beta endorphin because in this case, unlike the endomorphin, the amount within was so tiny, it was like a remnant of a smear sprayed on the inside of the plastic. It was, as Lincoln said "like the homeopathic soup boiled from the shadow of a pigoen that had starved to death"!

I think, it's funny. On the first order, their one milligram phial was very generous, a big fluffy mound that rolled out into the spoon! But the subsequent ones, because they were made to order, I think they were strict and stingy in the amount they gave, just purely to the letter of the law. Anyway, the rinse maybe yeilded about five milligrams all told if swim was lucky. Maybe less than that.

Anyway, the thing is, the beta endorphin was different. Slower onset, milder, not incapacitating like the endomorphin, and much more like a real opiATE, and get this; it gave an itch after about two minutes. Mild and pleasant, but again, definitely there, and it was not there with the other stuff. And no muscle tightness.

[Laudaphun]

Just SWIM's 2 cents but, the body produces endorphins that make morphine seem very weak. Probably not many conversion tables around and not easy to find if so. But, even 1 or 2mg or this stuff should be equivalent to a HUGE dose of morphine right? I suppose SWIM is just repeating the caution already expressed, but this stuff would make SWIM a little apprehensive.

[Handle]

Yes, in some senses, but not all. First of all, they are very, extremely short acting, nowhere near the duration of opiate alkaloids, because they are degraded by a different pathway, not P450 to my knowledge, but by [leucine] aminopeptidase enzymes, and so their peak without enzyme inhibition only goes for 15-30mins on average.

Second, because they are the real deal, they actually seem to be less sedating, cause less respiratory depression, and other funny effects like midriasis [forgot how to spell it] that give the overall impression of stimulants, unlike street opiATEs which as you said are a pale imitation. It is curious.

Also, there are many opiates that actually get more dangerous the weaker they are,
like dextropropoxyphene, which has a pretty low therapeutic index, so you don't feel blown away by it, so use escalates until the effective dose is right up near the toxic one. The thing is, that with stuff like fentanyl, even though doses get much smaller, the therapeutic index actually increases, meaning you get more "good" effects within the margin of risk, so sometimes stronger is not always worse.

The biggest worry with this stuff is mainly the overwhelming feelings that are brought on, I think in some they could create a panic attack.

My swim knew from the start he was going to face certain...hesitation at the experiment, but apart from the risk of using them in a non clinical setting, all those risks, he had certain advantages. He was absolutely sure of his doses, he was satisfied about purity because it was a research grade source, and there was some published stuff about trials with cancer patients so he could use that as a basis for comparison and reference.

It was a pretty similar situation to any RC really.

But data nad predictions can be way off, though. Look at how the theory was totally wrong about the BBB. If they were wrong about this stuff, maybe they were wrong about other chems as well, like serotonin...perhaps.

Anyway, people buy and shoot up shit off the street everyday, not knowing where it's been, or often, what it is. The risk to swim was no worse than the certain toll his ongoing heroin problems cause him.

Perhaps swIm could have killed swimself. Perhaps.

Reputation Comments on this post:

Great research, Thanks so much for sharing with DF! Keep up the great work. Please keep us all updated too =]

[Handle]

By the way, I don't live in the 5tr33t, or whatever you young'ns call it now, but I couldn't call it "illicit" because they ain't even controlled drugs to the best of my knowledge, so I just used street to connote "non-clinical" use. Connote or denote? I can't remember.